Results 241 to 250 of about 19,175,801 (290)

N4-acetylcytidine coordinates with NP1 and CPSF5 to facilitate alternative RNA processing during the replication of minute virus of canines. [PDF]

Nucleic Acids Res
Zhang X, Qin S, Huang F, Liu H, Wang J, Chen Z, Hao H, Ding S, Liu L, Yu B, Liu Y, Liu H, Guan W.   +12 more
europepmc   +1 more source

Hierarchical RNA Processing Is Required for Mitochondrial Ribosome Assembly.

Cell Reports, 2016
O. Rackham, Jakob D. Busch, Stanka Matic, S. Siira, Irina Kuznetsova, I. Atanassov, Judith A Ermer, A. Shearwood, Tara R. Richman, J. Stewart, Arnaud Mourier, Dusanka Milenkovic, N. Larsson, A. Filipovska   +13 more
semanticscholar   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

NS1-mediated DNMT1 degradation regulates human bocavirus 1 replication and RNA processing. [PDF]

PLoS Pathog
Qin S, Chen H, Tian C, Chen Z, Zuo L, Zhang X, Hao H, Huang F, Liu H, Sun X, Guan W.   +10 more
europepmc   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Identification of RNA processing factor LSM5 as a new adverse biomarker in nasopharyngeal carcinoma.

Sci Rep
Lin T, Deng L, Liu S, Chen Y, Tang Y, Zhou F, Gong G, He Y.   +7 more
europepmc   +1 more source

Epididymis-specific RNase A family genes regulate fertility and small RNA processing. [PDF]

J Biol Chem
Shaffer JF, Gupta A, Kharkwal G, Linares EE, Holmes AD, Swartz JR, Katzman S, Sharma U.   +7 more
europepmc   +1 more source

Long noncoding RNAs: Re-writing dogmas of RNA processing and stability.

Biochimica et Biophysica Acta, 2016
J. Wilusz
semanticscholar   +1 more source

The effect of salubrinal on the endoplasmic reticulum stress pathway in heat‐stressed spermatogonial cells in vitro

FEBS Open Bio, EarlyView.
This study investigates the protective role of salubrinal against heat‐induced endoplasmic reticulum (ER) stress in mouse spermatogenic cells (GC1 and GC2). By modulating the ER stress pathway, salubrinal alleviates cellular stress and supports spermatogenic cell survival, suggesting its potential as a therapeutic candidate for heat‐related infertility.
Suna Karadeniz Saygili, Mustafa Oztatlici, Mahmut Kemal Ozbilgin   +2 more
wiley   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source