Results 101 to 110 of about 1,674,122 (352)

Unlocking the potential of tumor‐derived DNA in urine for cancer detection: methodological challenges and opportunities

open access: yesMolecular Oncology, EarlyView.
Urine is a rich source of biomarkers for cancer detection. Tumor‐derived material is released into the bloodstream and transported to the urine. Urine can easily be collected from individuals, allowing non‐invasive cancer detection. This review discusses the rationale behind urine‐based cancer detection and its potential for cancer diagnostics ...
Birgit M. M. Wever   +1 more
wiley   +1 more source

Intelligent deep analysis of DNA sequences based on FFGM to enhancement the performance and reduce the computation

open access: yesEgyptian Informatics Journal, 2023
In an attempt to improve the analysis DNA sequence, a new intelligent deep analysis algorithm called reduce frequency bast on fast frequency graph mining (RF-FFGM) is established; This algorithm at the beginning converts the DNA sequence into RNA ...
Zena A. Kadhuim, Samaher Al-Janabi
doaj  

RNAome sequencing delineates the complete RNA landscape

open access: yesGenomics Data, 2015
Standard RNA expression profiling methods rely on enrichment steps for specific RNA classes, thereby not detecting all RNA species. For example, small and large RNAs from the same sample cannot be sequenced in a single sequence run.
Kasper W.J. Derks, Joris Pothof
doaj   +1 more source

RNA sequence analysis using covariance models

open access: yesNucleic Acids Research, 1994
We describe a general approach to several RNA sequence analysis problems using probabilistic models that flexibly describe the secondary structure and primary sequence consensus of an RNA sequence family. We call these models 'covariance models'. A covariance model of tRNA sequences is an extremely sensitive and discriminative tool for searching for ...
Richard Durbin, Sean R. Eddy
openaire   +3 more sources

Effect of Non-Coding RNA on Post-Transcriptional Gene Silencing of Alzheimer Disease [PDF]

open access: yes, 2010
A large amount of hidden biological information is contained in the human genome, which is not expressed or revealed in the form of proteins; the usual end product form of gene expression.
Arun Mohan   +7 more
core   +1 more source

Subpar reporting of pre‐analytical variables in RNA‐focused blood plasma studies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical variables strongly influence the analysis of extracellular RNA (cell‐free RNA; exRNA) derived from blood plasma. Their reporting is essential to allow interpretation and replication of results. By evaluating 200 exRNA studies, we pinpoint a lack of reporting pre‐analytical variables associated with blood collection, plasma preparation ...
Céleste Van Der Schueren   +16 more
wiley   +1 more source

Finding RNA structure in the unstructured RBPome

open access: yesBMC Genomics, 2018
Background RNA-binding proteins (RBPs) play vital roles in many processes in the cell. Different RBPs bind RNA with different sequence and structure specificities.
Yaron Orenstein   +2 more
doaj   +1 more source

Genesis of ancestral haplotypes: RNA modifications and reverse transcription–mediated polymorphisms [PDF]

open access: yes, 2011
Understanding the genesis of the block haplotype structure of the genome is a major challenge. With the completion of the sequencing of the Human Genome and the initiation of the HapMap project the concept that the chromosomes of the mammalian genome are
Carnegie, P.   +8 more
core   +2 more sources

Identification of functional and diverse circulating cancer‐associated fibroblasts in metastatic castration‐naïve prostate cancer patients

open access: yesMolecular Oncology, EarlyView.
Cancer‐associated fibroblasts (CAFs) promote cancer growth, invasion (metastasis), and drug resistance. Here, we identified functional and diverse circulating CAFs (cCAFs) in patients with metastatic prostate cancer (mPCa). cCAFs were found in higher numbers and were functional and diverse in mPCa patients versus healthy individuals, suggesting their ...
Richell Booijink   +6 more
wiley   +1 more source

RNA editing by ADAR1 leads to context-dependent transcriptome-wide changes in RNA secondary structure

open access: yesNature Communications, 2017
Adenosine deaminase acting on RNA 1 (ADAR1) edits adenosine to inosine. Here the authors, using parallel analysis of RNA secondary structure sequencing, provide evidence that ADAR1 induces sequence-context-dependent RNA secondary structures changes ...
Oz Solomon   +16 more
doaj   +1 more source

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