Results 101 to 110 of about 1,335,933 (257)

Differential gene expression in peripheral blood mononuclear cells from children immunized with inactivated influenza vaccine

Human Vaccines & Immunotherapeutics, 2020
The human immune response to inactivated influenza vaccine is dynamic and impacted by age and preexisting immunity. Our goal was to identify postvaccination transcriptomic changes in peripheral blood mononuclear cells from children.
John F. Alcorn, Raghunandan Avula, Anish B. Chakka, William E. Schwarzmann, Mary Patricia Nowalk, Chyongchiou Jeng Lin, Marianna A. Ortiz, William T. Horne, Uma R. Chandran, Jennifer P. Nagg, Richard K. Zimmerman, Kelly S. Cole, Krissy K. Moehling, Judith M. Martin   +13 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

RNA-sequencing transcriptome data of Laodelphax striatellus

, 2018
To determine how LsFoxO affects nymphal diapause, analyses of RNA-sequencing transcriptome data after treatment with LsFoxO–RNA interference was ...
Yifan Zhai (5737028)
core   +1 more source

General lack of global dosage compensation in ZZ/ZW systems? Broadening the perspective with RNA-seq [PDF]

, 2011
Background Species with heteromorphic sex chromosomes face the challenge of large-scale imbalance in gene dose. Microarray-based studies in several independent male heterogametic XX/XY systems suggest that dosage compensation mechanisms are in place to ...
Bryk, Jaroslaw,, Bryk, Jarek, Wolf, Jochen B. W.,, Wolf, Jochen BW, Bryk Jarosław, Wolf, Jochen B. W., Jochen BW Wolf, Bryk, J., Bryk, Jarosłav, Wolf, J., Jarosław Bryk, Wolf Jochen BW   +11 more
core   +2 more sources

Integration of Single-Cell RNA Sequencing and Bulk RNA Sequencing to Identify an Immunogenic Cell Death-Related 5-Gene Prognostic Signature in Hepatocellular Carcinoma

Journal of Hepatocellular Carcinoma
Liqun Peng,1,2 Shaohua Xu,3 Jian-Liang Xu4 1Department of Hepatobiliary and Pancreatic Surgery, Zhongnan Hospital of Wuhan University, Wuhan, People’s Republic of China; 2Clinical Medicine Research Center for Minimally Invasive Procedure of Hepatobiliary
Peng L, Xu S, Xu JL
doaj  

Molecular characteristics of drug-susceptible Mycobacterium tuberculosis clinical isolates based on treatment duration [PDF]

Osong Public Health and Research Perspectives
Objectives In this study, we performed comparative genomic and transcriptomic analysis of clinical isolates of Mycobacterium tuberculosis collected from patients with drug-susceptible tuberculosis (DS-TB).
Eon-Min Ko, Jinsoo Min, Hyungjun Kim, Ji-A Jeong, Sungkyoung Lee, Seonghan Kim   +5 more
doaj   +1 more source

Spontaneous rearrangements in RNA sequences

FEBS Letters, 1999
The ability of RNAs to spontaneously rearrange their sequences under physiological conditions is demonstrated using the molecular colony technique, which allows single RNA molecules to be detected provided that they are amplifiable by the replicase of bacteriophage Qβ.
Chetverina, Helena V, Demidenko, Alexander A, Ugarov, Victor I, Chetverin, Alexander B   +3 more
openaire   +2 more sources

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Sequencing accuracy and systematic errors of nanopore direct RNA sequencing

BMC Genomics
Background Direct RNA sequencing (dRNA-seq) on the Oxford Nanopore Technologies (ONT) platforms can produce reads covering up to full-length gene transcripts, while containing decipherable information about RNA base modifications and poly-A tail lengths.
Wang Liu-Wei, Wiep van der Toorn, Patrick Bohn, Martin Hölzer, Redmond P. Smyth, Max von Kleist   +5 more
doaj   +1 more source

Comparison of RNA-Sequencing Methods for Degraded RNA

International Journal of Molecular Sciences
RNA sequencing (RNA-Seq) is a powerful technique and is increasingly being used in clinical research and drug development. Currently, several RNA-Seq methods have been developed. However, the relative advantage of each method for degraded RNA and low-input RNA, such as RNA samples collected in the field of clinical setting, has remained unknown.
Hiroki Ura, Yo Niida
openaire   +2 more sources