Results 211 to 220 of about 1,474,432 (298)

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

A general approach for detecting expressed mutations in AML cells using single cell RNA-sequencing [PDF]

, 2019
Chen, David Y., Church, Deanna M., Fiddes, Ian T., Fronick, Catrina C., Fulton, Robert S., Ley, Timothy J., Miller, Christopher A., Petti, Allegra A., Srivatsan, Sridhar N., Williams, Stephen R.   +9 more
core   +1 more source

RNA sequencing in ovarian cancer research: a comprehensive review. [PDF]

J Ovarian Res
Shen F, Li C, Li Y, Shen Y, Han F.
europepmc   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Single-cell RNA sequencing identifies microglial state changes associated with iTBS after ischemia-reperfusion injury. [PDF]

PLoS One
Huang Y, Zhao Y, Zhang X, Bi X.
europepmc   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Single-cell RNA sequencing uncovers neutrophil clusters associated with autoimmune neuroinflammation. [PDF]

J Neuroinflammation
Wang Y, Turbitt WJ, Zhou L, Yan Z, Patel SB, Yang W, Li Z, Buckley JA, Mulia G, Welner RS, Meador WR, Raman C, Qin H, Benveniste EN.   +13 more
europepmc   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source