Results 1 to 10 of about 293,102 (292)
RNA-guided RNA silencing by an Asgard archaeal Argonaute. [PDF]
Nat Commun, 2023 AbstractArgonaute proteins are the central effectors of RNA-guided RNA silencing pathways in eukaryotes, playing crucial roles in gene repression and defense against viruses and transposons. Eukaryotic Argonautes are subdivided into two clades: AGOs generally facilitate miRNA- or siRNA-mediated silencing, while PIWIs generally facilitate piRNA-mediated
Bastiaanssen C +13 more
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RNA Silencing in the Management of Dyslipidemias. [PDF]
Curr Atheroscler Rep, 2021 Abstract Purpose of Review Remarkable reductions in cardiovascular morbidity and mortality have been achieved in recent decades through the widespread use of ‘small-molecule’ hypolipidaemic drugs such as statins and ezetimibe. An alternative approach is to perturb the production of proteins through ribonucleic acid (RNA)
Henney NC, Banach M, Penson PE.
europepmc +5 more sources
Identification of RNA silencing suppressor encoded by citrus chlorotic dwarf-associated virus [PDF]
Frontiers in MicrobiologyIntroductionCitrus chlorotic dwarf-associated virus (CCDaV) is an economically important citrus virus associated with leaf curling, deformation, and chlorosis found in China.
Xiao Ye +6 more
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Resistance gene Ty-1 restricts TYLCV infection in tomato by increasing RNA silencing [PDF]
Virology JournalA major antiviral mechanism in plants is mediated by RNA silencing through the action of DICER-like (DCL) proteins, which cleave dsRNA into discrete small RNA fragments, and ARGONAUTE (AGO) proteins, which use the small RNAs to target single-stranded RNA.
Xiaofang Ma +3 more
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Silencing viruses with RNA [PDF]
Nature, 2002 Our cells have a built-in mechanism for 'silencing' genes, called RNA interference. This capability has now been exploited to protect cells in culture dishes from HIV-1 and poliovirus.
Gordon Carmichael
openalex +3 more sources
RNA silencing sheds light on the RNA world. [PDF]
PLoS Biology, 2006 RNA silencing — also known as RNA interference — is an intriguing phenomenon in which short, double-stranded RNA “triggers” can prevent the expression of specific genes. First discovered in plants, RNA interference is now recognized as a widespread, if not ubiquitous, phenomenon, and it is causing great excitement as an experimental technique for ...
Rachel Jones
doaj +5 more sources
Non-Coding RNA, 2021 RNA silencing pathways control eukaryotic gene expression transcriptionally or posttranscriptionally in a sequence-specific manner. In RNA silencing, the production of double-stranded RNA (dsRNA) gives rise to various classes of 20–24 nucleotide (nt ...
Xia Hua +5 more
doaj +1 more source
Current Biology, 2007 PIWI-interacting RNAs (piRNAs), 24–30 nucleotide long RNAs found in the germ cells of animals, are unique among small silencing RNAs in that they require neither an RdRP nor Dicer for their production (Figure 1Figure 1C). Instead, they are thought to derive from single-stranded precursor RNAs tens or hundreds of thousands of nucleotides long.
Christian B. Matranga, Phillip D. Zamore
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RNA Silencing and the Mobile Silencing Signal [PDF]
The Plant Cell, 2002 RNA silencing is a sequence-specific RNA degradation mechanism that occurs in a broad range of eukaryotic organisms including fungi (quelling), animals (RNA interference [RNAi]), and plants (post-transcriptional gene silencing).
Gail J. Pruss +7 more
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RNA decay is an antiviral defense in plants that is counteracted by viral RNA silencing suppressors. [PDF]
PLoS Pathogens, 2018 Exonuclease-mediated RNA decay in plants is known to be involved primarily in endogenous RNA degradation, and several RNA decay components have been suggested to attenuate RNA silencing possibly through competing for RNA substrates.
Fangfang Li, Aiming Wang
doaj +1 more source