Results 251 to 260 of about 1,733,662 (377)

The RNA-Induced Silencing Complex Is a Mg2+-Dependent Endonuclease [PDF]

, 2004
Dianne S. Schwarz, Yukihide Tomari, Phillip D. Zamore   +2 more
openalex   +1 more source

Targeting Intratumoral Copper Inhibits Tumor Progression via p62‐Mediated EZH2 Degradation and Potentiates Anti‐PD‐1 Immunotherapy in Oral Squamous Cell Carcinoma

Advanced Science, EarlyView.
The authors find that by targeting intratumoral copper, they can enhance p62‐mediated ubiquitination of EZH2 at the Ub‐K63 site by suppressing copper binding to SMURF2, an E3 ligase of EZH2, leading to its autophagic degradation. This mechanism suppressed OSCC progression and potentiated anti‐PD‐1 immunotherapy, highlighting a potential new therapeutic
Xiaohu Lin, Wanling Chen, Bo Li, Zhang Zhao, Zhonglin Yu, Xu‐Yun Zhao, Xuan Zhou, Zhien Feng, Chengzhong Lin, Wei Cao   +9 more
wiley   +1 more source

Advances in RNA-Silencing-Related Resistance against Viruses in Potato. [PDF]

Genes (Basel), 2022
Jiang L, Du Z, Zhang G, Wang T, Jin G.
europepmc   +1 more source

Dissection of a Natural RNA Silencing Process in the Drosophila melanogaster Germ Line [PDF]

, 2004
Alexei A. Aravin, Mikhail S. Klenov, V. V. Vagin, Frédéric Bantignies, Giacomo Cavalli, В. А. Гвоздев   +5 more
openalex   +1 more source

Nrf2 Drives Epigenetic Reprogramming and Acts as the Master Regulator of KLF4 Expression and Activity in Arsenic‐Induced Transformation

Advanced Science, EarlyView.
Nrf2 isn't just a protector—it's a driver of cancer stemness. The study uncovers how arsenic‐activated Nrf2 directly upregulates KLF4, a key pluripotency factor, fueling oncogenic reprogramming. Through enhancer activation and self‐reinforcing loop, Nrf2 and KLF4 co‐opt gene networks linked to epithelial‐to‐mesenchymal transition and tumor growth ...
Ziwei Wang, Zhuoyue Bi, Jessica Bamrah, Yiran Qiu, Wenxuan Zhang, Bandar Saeed Almutairy, Haoyan Ji, John D. Haley, Chitra Thakur, Fei Chen   +9 more
wiley   +1 more source

Genome-wide identification, characterization and expression analysis of key gene families in RNA silencing in centipedegrass. [PDF]

BMC Genomics
Liu S, Lei X, Gou W, Xiong C, Min W, Kong D, Wang X, Liu T, Ling Y, Ma X, Zhao J.   +10 more
europepmc   +1 more source

Tomato chlorosis virus CPm protein is a pathogenicity determinant and suppresses host local RNA silencing induced by single-stranded RNA. [PDF]

Front Microbiol, 2023
Yang X, Luo X, Zhang Y, Zhang Z, OuYang X, Shi X, Lv X, Li F, Zhang S, Liu Y, Zhang D.   +10 more
europepmc   +1 more source

Insulin signaling through Akt/protein kinase B analyzed by small interfering RNA-mediated gene silencing

, 2003
Zhen Jiang, Qiong Zhou, Kerri Ann Coleman, My Chouinard, Queta Boese, Michael Czech   +5 more
openalex   +1 more source

Pigment Epithelium‐Derived Factor Deficiency Impairs Hippocampal Glutamate Homeostasis and Cognitive Function by Downregulating Astrocytic GLT‐1

Advanced Science, EarlyView.
The chronic glutamate‐induced excitotoxicity hypothesis has profoundly informed the therapeutic strategies employed in Alzheimer’s disease (AD). This study shows pigment epithelium‐derived factor (PEDF) regulates astrocytic glutamate transporter‐1 (GLT‐1)‐mediated glutamate homeostasis and cognition. Reduced PEDF correlates with lower Mini‐Mental State
Jin‐Hui Shi, Qi‐Long Tang, Jin‐Hong Wang, Yan‐Lan Long, Sai‐Feng Zhao, Zhen Zhao, Wan‐Ting Xie, Zi‐Ming Li, Hao‐Ming Lu, Tian‐Xiao Gao, Zhen‐Zhen Fang, Ti Zhou, Bo‐Xing Li, Xia Yang, Guo‐Quan Gao, Wei‐Wei Qi   +15 more
wiley   +1 more source

Role of Bean Yellow Mosaic Virus P1 and HC-Pro in Enhancing Gene Expression and Suppressing RNA Silencing in <i>Nicotiana benthamiana</i>. [PDF]

Life (Basel)
Choi S, Kwon SH, Kwon GS, Choi HS, Seo HH, Kim YS, Lee JH, Cho WK, Moh SH.   +8 more
europepmc   +1 more source