Advanced Materials for Biologics Delivery to Brain Tumors
Advanced Materials, EarlyView.Material innovation is central to unlocking the therapeutic potential of biologics against many central nervous system diseases, including brain cancer. By engineering carriers with controlled transport, targeting, and release properties, advanced materials can overcome the blood–brain barrier and tumor microenvironment, improving the delivery of ...
Yuran Feng +4 more
wiley +1 more source
RNA decay is an antiviral defense in plants that is counteracted by viral RNA silencing suppressors
PLOS Pathogens, 2018 Exonuclease-mediated RNA decay in plants is known to be involved primarily in endogenous RNA degradation, and several RNA decay components have been suggested to attenuate RNA silencing possibly through competing for RNA substrates. In this paper, we report that overexpression of key cytoplasmic 5'-3' RNA decay pathway gene-encoded proteins (5'RDGs ...
Fangfang Li, Aiming Wang
openaire +4 more sources
Manipulation of plant host susceptibility: an emerging role for viral movement proteins?
Frontiers in Plant Science, 2012 Viruses encode Viral Suppressors of RNA silencing (VSRs) to counteract RNA silencing, a major antiviral defense response in plants. Recent studies indicate a role of virus-derived siRNAs in manipulating the expression of specific host genes and that ...
Khalid eAmari +4 more
doaj +1 more source
Coat protein of partitiviruses isolated from mycorrhizal fungi functions as an RNA silencing suppressor in plants and fungi. [PDF]
Sci Rep, 2022 Shimura H +4 more
europepmc +1 more source
Bacteria‐Trained, MnO2‐Armored Dendritic Cells for Immunotherapy
Advanced Materials, EarlyView.MnO2‐armored, bacteria‐trained dendritic cells undergo tumor‐responsive mechanical and immunological transformation. The nanocoating masks immune ligands and maintains a mechanically stiff, quiescent state during circulation, while the tumor microenvironment removes the armor and restores cellular deformability and immune accessibility.
Zhao Guo +9 more
wiley +1 more source
Assessment of the RNA Silencing Suppressor Activity of Protein P0 of Pepper Vein Yellows Virus 5: Uncovering Natural Variability, Relevant Motifs and Underlying Mechanism. [PDF]
Biology (Basel), 2022 Pérez-Cañamás M +5 more
europepmc +1 more source
Advanced Materials, EarlyView.Neutrophil extracellular traps (NETs) emerge as a critical repair‐limiting factor in osteomyelitis, driving osteoblast mitochondrial dysfunction and excessive PINK1/Parkin‐mediated mitophagy. Gallium–selenium nanoparticles (GaSex) scavenge reactive oxygen species, redirect neutrophils from NETosis toward bactericidal phagocytosis, eliminate methicillin‐
Kai Ye +11 more
wiley +1 more source
RNA silencing suppressors encoded by viruses of the family Tombusviridae
Plant Biotechnology, 2005 RNA silencing is a sequence-specific gene-inactivation mechanism conserved among eukaryotes that functions as an antiviral defense in plants and animals. To counteract this defense, viruses encode RNA silencing suppressors. Over 30 RNA silencing suppressors have been identified, but the mechanisms by which they suppress RNA silencing is unclear for ...
Takeda, Atsushi +2 more
openaire +2 more sources
Identification of an RNA Silencing Suppressor Encoded by a Symptomless Fungal Hypovirus, Cryphonectria Hypovirus 4. [PDF]
Biology (Basel), 2021 Aulia A +5 more
europepmc +1 more source
Advanced Science, EarlyView.This study identified Danofloxacin as a novel supporter of the maintenance of mouse embryonic stem cell (ESC) pluripotency. It functions partially by inhibiting HDAC1, which increases specific histone acetylation marks and activates key genes like Tert and Prdm10.
Yan Zhang +8 more
wiley +1 more source