Results 211 to 220 of about 106,855 (258)

SIRT7 Mediated-PTEN Desuccinylation Drives Gastric Tumorigenesis by Activating PI3K/AKT Pathway. [PDF]

J Biochem Mol Toxicol
Liao B, Hu S, Zhang Q, Xu Q, Tian T.
europepmc   +1 more source

D4F‐Functionalized Ceria Nanozyme‐CasRx Platform Suppresses STING and Reprograms the Renal Immune Niche in Acute Kidney Injury

Advanced Science, EarlyView.
D4F‐functionalized ceria nanozyme–CasRx nanoparticles preferentially target renal macrophages through SR‐B1‐mediated uptake in ischemia–reperfusion injury. Ceria scavenges excessive ROS, while CasRx silences STING signaling, shifting macrophages toward a less inflammatory, pro‐resolving state and increasing the proportion of regulatory T cells.
Weibo Chen, Ming Li, Xuesheng Wang, Jiajia Sun, Ziyuan Zhang, Yongfeng Gong, Benkang Shi, Nengwang Yu, Yunuo Mao, Shengtian Zhao, Xiulin Zhang, Liqiang Guo   +11 more
wiley   +1 more source

Epigenetic Reactivation of TNFRSF19 Suppresses Mitophagy and Sensitizes Triple‐Negative Breast Cancer to Doxorubicin

Advanced Science, EarlyView.
TNFRSF19 is an epigenetically silenced regulator of mitophagy in triple‐negative breast cancer. TNFRSF19 deficiency activates the TGFBR1–SMAD3–PINK1 axis to promote mitophagy and confer doxorubicin resistance, whereas decitabine‐mediated restoration of TNFRSF19 suppresses mitophagy and enhances doxorubicin sensitivity, revealing a targetable epigenetic–
Shiyang Liu, Chenguang Liu, Weihong Zheng, Xiaofei Tong, Zhengwei Gui, Zonghong Lu, Sun Ieong, Lin Zhang   +7 more
wiley   +1 more source

Targeting METTL3/m6A/SOCS3 axis reprograms tumor-associated macrophage polarization to potentiate the efficacy of anti-PD-1 therapy in multiple myeloma. [PDF]

Cell Mol Life Sci
Wang G, Zhou F, Yan X, Wang J, Yan M, Liu J, Yu L.   +6 more
europepmc   +1 more source

Single‐Molecule Imaging of Endogenous RNA Using a Miniaturized and Circularly Permuted CRISPR‐Cas13 Degron‐Masking System CDegSR

Advanced Science, EarlyView.
CDegSR, a new tool for imaging RNA at single molecule level in living cells was developed by researchers. Background noise was eliminated by protein engineering and making it degrade when not bound to its target. This allowed individual RNA molecules to be clearly imaged and tracked.
Shipeng Shao, Hongchen Zhang
wiley   +1 more source

lncRNA HOTAIR in Cancer: Recent Advances and Critical Perspectives on Molecular Mechanisms. [PDF]

Cancer Manag Res
Hu Z, Yan B.
europepmc   +1 more source

Targeting LDHA Palmitoylation Sensitizes GBM to Chemoradiotherapy via Suppressing Palmitic Acid Induced Glycolytic Reprogramming

Advanced Science, EarlyView.
Mesenchymal GSCs preferentially uptake palmitic acid, thereby promoting ZDHHC12‐mediated LDHA palmitoylation. This modification enhances LDHA enzymatic activity, drives glycolytic reprogramming, and facilitates exosomal LDHA‐mediated TAM regulation.
Zijie Gao, Rongrong Zhao, Zheyuan Chen, Qingtong Wang, Huanyu Yang, Boyan Li, Yanhua Qi, Shulin Zhao, Jixing Zhao, Jiawei Qiu, Ziwen Pan, Zhe Han, Ruochuan Li, Huize Xia, Weijie Tang, Xing Guo, Ping Zhang, Hongyu Zhao, Xu Qian, Gang Li, Hao Xue   +20 more
wiley   +1 more source

Current Evidence on Gene-Based and Epigenetic Therapeutic, Diagnostic, and Prognostic Strategies in Epithelial-Derived Carcinomas: A Scoping Review. [PDF]

Biomedicines
Thomas JG, Ayyub M, Annamma LM, Prasad P, Azim SA, Varma S, George BT, Khair AMB.   +7 more
europepmc   +1 more source

Editorial: The role of RNA regulation in cancer pathogenesis and therapeutic strategies. [PDF]

Front Oncol
Wakahashi S, Azumi M, Minagawa K.
europepmc   +1 more source

Epigenetic silencing of PDLIM4 promotes colorectal cancer by impairing BTF3 autophagic degradation and activating PI3K/Akt signalling. [PDF]

Clin Transl Med
Wang J, Guo CG, Qi L, Hou S, Lin B, Ye T, Zong Y, Zhang S, Zhang N, Li P, Liu S.   +10 more
europepmc   +1 more source