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Direct and Indirect Roles of Viral Suppressors of RNA Silencing in Pathogenesis
Annual Review of Phytopathology, 2008Plant and animal viruses overcome host antiviral silencing by encoding diverse viral suppressors of RNA silencing (VSRs). Prior to the identification and characterization of their silencing suppression activities mostly in transgene silencing assays, plant VSRs were known to enhance virus accumulation in the inoculated protoplasts, promote cell-to-cell
Juan Antonio Díaz-Pendón +1 more
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Suppressing RNA silencing with small molecules and the viral suppressor of RNA silencing protein p19
Biochemical and Biophysical Research Communications, 2015RNA silencing is a gene regulatory and host defense mechanism whereby small RNA molecules are engaged by Argonaute (AGO) proteins, which facilitate gene knockdown of complementary mRNA targets. Small molecule inhibitors of AGO represent a convenient method for reversing this effect and have applications in human therapy and biotechnology.
Danielson, Dana C. +4 more
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Crystal structure of p19 ? a universal suppressor of RNA silencing
Trends in Biochemical Sciences, 2004RNA silencing in plants has an antiviral role and, consequently, plant viruses encode counter-defensive suppressor proteins that block this process. The recently reported crystal structure of two Tombusvirus suppressor proteins reveals a novel RNA-binding structure and illustrates precisely how the silencing mechanism is blocked.
David C, Baulcombe, Attila, Molnár
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Effects and side-effects of viral RNA silencing suppressors on short RNAs
Trends in Plant Science, 2004In eukaryotes, short RNAs play a crucial regulatory role in many processes including development, maintenance of genome stability and antiviral responses. These different but overlapping RNA-guided pathways are collectively termed 'RNA silencing'. To counteract an antiviral RNA silencing response, plant viruses express silencing suppressor proteins ...
Dániel, Silhavy, József, Burgyán
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The dual edge of RNA silencing suppressors in the virus–host interactions
Current Opinion in Virology, 2016RNA silencing (or RNA interference, RNAi) plays a key role in the plant antiviral defense. To facilitate infection, viruses encode suppressors of RNA silencing (VSRs) to counteract antiviral defense. In the co-evolutionary arms race between hosts and viruses, extreme viral accumulation does not benefit either hosts or viruses.
Jian-Hua, Zhao +3 more
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Identification and RNA binding characterization of plant virus RNA silencing suppressor proteins
Methods, 2013Suppression is a common mechanism employed by viruses to evade the antiviral effects of the host's RNA silencing pathway. The activity of suppression has commonly been localized to gene products in the virus, but the variety of mechanisms used in suppression by these viral proteins spans nearly the complete biochemical pathway of RNA silencing in the ...
Vargason, Jeff +2 more
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Journal of General Plant Pathology, 2011
RNA silencing is triggered by double-stranded RNAs (dsRNAs), and the dsRNAs are processed into 21to 24-nulceotide (nt) short interfering RNAs (siRNAs) by a host dsRNA-specific ribonuclease, Dicer. The siRNAs are subsequently incorporated into ARGONAUTE (AGO) proteins and serve as a guide for either sequence-specific cleavage or translational repression
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RNA silencing is triggered by double-stranded RNAs (dsRNAs), and the dsRNAs are processed into 21to 24-nulceotide (nt) short interfering RNAs (siRNAs) by a host dsRNA-specific ribonuclease, Dicer. The siRNAs are subsequently incorporated into ARGONAUTE (AGO) proteins and serve as a guide for either sequence-specific cleavage or translational repression
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Biological Chemistry of Virus-Encoded Suppressors of RNA Silencing: An Overview
2012RNA interference (RNAi) plays multiple biological roles in eukaryotic organisms to regulate gene expression. RNAi also operates as a conserved adaptive molecular immune mechanism against invading viruses. The antiviral RNAi pathway is initiated with the generation of virus-derived short-interfering RNAs (siRNAs) that are used for subsequent sequence ...
Rustem T, Omarov, Herman B, Scholthof
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Modulation of Noncoding RNAs (ncRNAs) and Their Potential Role as Therapeutics
Medical Epigenetics, 2021Luciano Pirola +2 more
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