Results 61 to 70 of about 106,855 (258)

Suppressors of RNA silencing encoded by geminiviruses and associated DNA satellites [PDF]

VirusDisease, 2018
In plants, RNA silencing provides a major line of defence against viruses. This antiviral immunity involves production of virus-derived small interfering RNAs (vsiRNAs) and results in specific silencing of viruses by vsiRNAs-guided effector complexes.
Rashmi Rishishwar, Indranil Dasgupta
openaire   +2 more sources

Amino Acid Sequence Motifs Essential for P0-Mediated Suppression of RNA Silencing in an Isolate of Potato leafroll virus from Inner Mongolia

Molecular Plant-Microbe Interactions, 2014
Polerovirus P0 suppressors of host gene silencing contain a consensus F-box-like motif with Leu/Pro (L/P) requirements for suppressor activity. The Inner Mongolian Potato leafroll virus (PLRV) P0 protein (P0PL-IM) has an unusual F-box-like motif that ...
Tao Zhuo, Yuan-Yuan Li, Hai-Ying Xiang, Zhan-Yu Wu, Xian-Bin Wang, Ying Wang, Yong-Liang Zhang, Da-Wei Li, Jia-Lin Yu, Cheng-Gui Han   +9 more
doaj   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Targeting of Dicer-2 and RNA by a Viral RNA Silencing Suppressor in Drosophila Cells [PDF]

Journal of Virology, 2012
ABSTRACT RNA interference (RNAi) is a eukaryotic gene-silencing mechanism that functions in antiviral immunity in diverse organisms. To combat RNAi-mediated immunity, viruses encode viral suppressors of RNA silencing (VSRs) that target RNA and protein components in the RNAi machinery.
Nan, Qi, Lei, Zhang, Yang, Qiu, Zhaowei, Wang, Jie, Si, Yongxiang, Liu, Xue, Xiang, Jiazheng, Xie, Cheng-Feng, Qin, Xi, Zhou, Yuanyang, Hu   +10 more
openaire   +2 more sources

Combined expression of p20 and p23 proteins from Citrus tristeza virus show enhanced local silencing suppressor activity

Phytopathologia Mediterranea, 2016
Viruses developed a strategy to counter-defence the posttranscriptional gene silencing mechanism (PTGS) based on the activity of silencing suppressor proteins. Citrus tristeza virus (CTV), a member of the genus Closterovirus, has two suppressor proteins (
Ângela COSTA, Tatiana MARTINS, Natália MARQUES, Gustavo Nolasco   +3 more
doaj   +1 more source

Reprogramming of RNA silencing triggered by cucumber mosaic virus infection in Arabidopsis

Genome Biology, 2021
Background RNA silencing has an important role mediating sequence-specific virus resistance in plants. The complex interaction of viruses with RNA silencing involves the loading of viral small interfering RNAs (vsiRNAs) into its host ARGONAUTE (AGO ...
Maria Luz Annacondia, German Martinez
doaj   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

Identification of an RNA Silencing Suppressor from a Plant Double-Stranded RNA Virus [PDF]

Journal of Virology, 2005
ABSTRACT RNA silencing is a mechanism which higher plants and animals have evolved to defend against viral infection in addition to regulation of gene expression for growth and development. As a counterdefense, many plant and some animal viruses studied to date encode RNA silencing suppressors (RSS) that interfere with various ...
Xuesong, Cao, Peng, Zhou, Xiaoming, Zhang, Shifeng, Zhu, Xuehua, Zhong, Qi, Xiao, Biao, Ding, Yi, Li   +7 more
openaire   +2 more sources

Root-Knot Nematode Parasitism Suppresses Host RNA Silencing

Molecular Plant-Microbe Interactions, 2017
Root-knot nematodes damage crops around the world by developing complex feeding sites from normal root cells of their hosts. The ability to initiate and maintain this feeding site (composed of individual “giant cells”) is essential to their parasitism ...
E. Walsh, J. M. Elmore, C. G. Taylor
doaj   +1 more source