Results 41 to 50 of about 106,855 (258)

Screening and Identification of Virus-Encoded RNA Silencing Suppressors [PDF]

, 2008
RNA silencing, including RNA interference, is a novel method of gene regulation and one of the potent host-defense mechanisms against the viruses. In the course of evolution, the viruses have encoded proteins with the potential to suppress the host RNA silencing mechanism as a counterdefense strategy.
Karjee, Sumona, Islam, Mohammad Nurul, Mukherjee, Sunil K.   +2 more
openaire   +2 more sources

Evidence that HIV-1 Encodes an siRNA and a Suppressor of RNA Silencing [PDF]

Immunity, 2005
In plants and invertebrate animals, RNA silencing is a form of nucleic acid-based adaptive immunity. By contrast, jawed vertebrates have evolved complex protein-based adaptive immunity. Although short interfering RNAs (siRNAs) have been used as artificial tools to silence viral infection in human cells, it remains unknown whether mammalian viruses ...
Bennasser, Yamina, Le, Shu-Yun, Benkirane, Monsef, Jeang, Kuan-Teh   +3 more
openaire   +4 more sources

Enhanced resistance and neutralization of defense responses by suppressors of RNA silencing [PDF]

Virus Research, 2007
The effects of transgenic expression of the potato virus Y (PVY) HCPro silencing suppressor in tobacco were examined on infection by several viruses. Infection by tobacco mosaic virus (TMV) was reduced at 25 degrees C, but not at 33 degrees C. By contrast, systemic infection at 33 degrees C by the TMV expressing green fluorescent protein was promoted ...
Shams-Bakhsh, Masoud, Canto, Tomas, Palukaitis, Peter   +2 more
openaire   +4 more sources

The Benyvirus RNA Silencing Suppressor Is Essential for Long-Distance Movement, Requires Both Zinc-Finger and NoLS Basic Residues but Not a Nucleolar Localization for Its Silencing-Suppression Activity

Molecular Plant-Microbe Interactions, 2013
The RNA silencing-suppression properties of Beet necrotic yellow vein virus (BNYVV) and Beet soil-borne mosaic virus (BSBMV) cysteine-rich p14 proteins have been investigated.
Sotaro Chiba, Kamal Hleibieh, Alice Delbianco, Elodie Klein, Claudio Ratti, Véronique Ziegler-Graff, Salah Bouzoubaa, David Gilmer   +7 more
doaj   +1 more source

Tat RNA silencing suppressor activity contributes to perturbation of lymphocyte miRNA by HIV-1

Retrovirology, 2011
Background MicroRNA (miRNA)-mediated RNA silencing is integral to virtually every cellular process including cell cycle progression and response to virus infection.
Yu Lianbo, Qian Shuiming, Hayes Amy M, Boris-Lawrie Kathleen   +3 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

A Versatile Assay for the Identification of RNA Silencing Suppressors Based on Complementation of Viral Movement

Molecular Plant-Microbe Interactions, 2008
The cell-to-cell movement of Turnip crinkle virus (TCV) in Nicotiana benthamiana requires the presence of its coat protein (CP), a known suppressor of RNA silencing. RNA transcripts of a TCV construct containing a reporter gene (green fluorescent protein)
Jason G. Powers, Tim L. Sit, Feng Qu, T. Jack Morris, Kook-Hyung Kim, Steven A. Lommel   +5 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Suppressor of RNA silencing encoded by Beet yellows virus

Virology, 2003
Using an Agrobacterium-mediated transient assay, we screened the 15.5-kb genome of the Beet yellows virus for proteins with RNA silencing suppressor activity. Among eight proteins tested, only a 21-kDa protein (p21) was able to suppress double-stranded (ds) RNA-induced silencing of the green fluorescent protein (GFP) mRNA. Restoration of GFP expression
Reed, Jonathan C, Kasschau, Kristin D, Prokhnevsky, Alexey I, Gopinath, Kodetham, Pogue, Gregory P, Carrington, James C, Dolja, Valerian V   +6 more
openaire   +2 more sources

Two Novel Motifs of Watermelon Silver Mottle Virus NSs Protein Are Responsible for RNA Silencing Suppression and Pathogenicity. [PDF]

PLoS ONE, 2015
The NSs protein of Watermelon silver mottle virus (WSMoV) is the RNA silencing suppressor and pathogenicity determinant. In this study, serial deletion and point-mutation mutagenesis of conserved regions (CR) of NSs protein were performed, and the ...
Chung-Hao Huang, Weng-Rong Hsiao, Ching-Wen Huang, Kuan-Chun Chen, Shih-Shun Lin, Tsung-Chi Chen, Joseph A J Raja, Hui-Wen Wu, Shyi-Dong Yeh   +8 more
doaj   +1 more source