Results 101 to 110 of about 384,167 (334)

Circular RNAs: splicing's enigma variations [PDF]

The EMBO Journal, 2013
Nature advance online publication February272013; doi:10.1038/nature11993 Nature advance online publication February272013; doi:10.1038/nature11928 Circular (circ)RNAs are to transcriptomics what the famous hidden musical theme is to Elgar's Enigma Variations: woven into the entire composition but not unambiguously identified or understood by ...
Hentze, Matthias, Preiss, Thomas
openaire   +3 more sources

Evolutionary dynamics of the chloroplast genome in Daphne (Thymelaeaceae): comparative analysis with related genera and insights into phylogenetics

FEBS Open Bio, EarlyView.
Comparative analysis of chloroplast genomes from 14 genera of Thymelaeaceae revealed variation in gene content, ranging from 128 to 142 genes, primarily influenced by IR expansion/contraction events and pseudogenization of ndhF, ndhI, and ndhG. Two large inversions were detected within the large single‐copy region, including a synapomorphic inversion ...
Abdullah, Hui Li, Rushan Yan, Chengyu Chen, Madiha Islam, Abdul Majid, Ibrar Ahmed, Parviz Heidari, Xiaoxuan Tian   +8 more
wiley   +1 more source

αCP binding to a cytosine-rich subset of polypyrimidine tracts drives a novel pathway of cassette exon splicing in the mammalian transcriptome. [PDF]

, 2016
Alternative splicing (AS) is a robust generator of mammalian transcriptome complexity. Splice site specification is controlled by interactions of cis-acting determinants on a transcript with specific RNA binding proteins.
Bahrami-Samani, Emad, Duncan-Lewis, Christopher, Ji, Xinjun, Liebhaber, Stephen A, Lin, Lan, Park, Juw Won, Pherribo, Gordon, Xing, Yi   +7 more
core   +1 more source

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source

RNA splicing during terminal erythropoiesis [PDF]

Current Opinion in Hematology, 2017
Purpose of review Erythroid progenitors must accurately and efficiently splice thousands of pre-mRNAs as the cells undergo extensive changes in gene expression and cellular remodeling during terminal erythropoiesis.
openaire   +2 more sources

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Alternative Splicing of Circadian Clock Genes Correlates With Temperature in Field-Grown Sugarcane [PDF]

, 2019
Alternative Splicing (AS) is a mechanism that generates different mature transcripts from precursor mRNAs (pre-mRNAs) of the same gene. In plants, a wide range of physiological and metabolic events are related to AS, as well as fast responses to changes ...
Alabadí, Amorim, Annunziata, Annunziata, Beyer, Bieniawska, Calixto, Calixto, Calixto, Calixto, Chamala, Chan, Chaudhary, Cuadrado, Dantas, de Setta, Ding, Dodd, Dodd, D’Hont, D’Hont, Endo, Filichkin, Filichkin, Filichkin, Filichkin, Fouquet, Frank, Fung-Uceda, Garcia, Garsmeur, Godoy Herz, Graf, Graf, Graveley, Grundy, Göhring, Harmer, Haydon, Higashi, Hotta, Hsu, Iskandar, Izawa, Izawa, Jabre, Jacob, James, James, James, Jones, Kalyna, Khan, Ko, Kornblihtt, Kriechbaumer, Kwon, Lai, Liu, Locke, Lu, Marquez, Marshall, Mastrangelo, McClung, McCormick, Millar, Miller, Min, Moll, Moore, Murakami, Nagano, Nagashima, Nakamichi, Ng, Ni, Oesterreich, Palusa, Para, Park, Pokhilko, Reddy, Remy, Riaño-Pachón, Richards, Rosloski, Saldi, Sato, Seo, Seo, Severing, Shalit-Kaneh, Shang, Shen, Simpson, Simpson, Souza, Staiger, Staiger, Sugliani, Syed, Szakonyi, Thatcher, Vaneechoutte, Vicentini, Wang, Zeilinger, Zhang, Zhang, Zhang, Zhang   +111 more
core   +2 more sources

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Domain associated with zinc fingers‐containing NF90‐NF45 complex inhibits m6A modification of primary microRNA by suppressing METTL3/14 activity

FEBS Open Bio, EarlyView.
NF90–NF45 functions as a negative regulator of methyltransferase‐like 3/14 (METTL3/14)‐mediated N6‐methyladenosine (m6A) modification on primary microRNAs (pri‐miRNAs). NF90–NF45 binds to anti‐oncogenic pri‐miRNAs and inhibits their m6A modification, thereby suppressing the biogenesis of anti‐oncogenic miRNAs.
Takuma Higuchi, Shunsuke Morioka, Keiko Morisawa, Kazutsugu Matsukawa, Shingo Ashida, Takeshi Suzuki, Shuji Sakamoto   +6 more
wiley   +1 more source

CIRCexplorer3: A CLEAR Pipeline for Direct Comparison of Circular and Linear RNA Expression

Genomics, Proteomics & Bioinformatics, 2019
Sequences of circular RNAs (circRNAs) produced from back-splicing of exon(s) completely overlap with those from cognate linear RNAs transcribed from the same gene loci with the exception of their back-splicing junction (BSJ) sites. Therefore, examination
Xu-Kai Ma, Meng-Ran Wang, Chu-Xiao Liu, Rui Dong, Gordon G. Carmichael, Ling-Ling Chen, Li Yang   +6 more
doaj   +1 more source