Results 121 to 130 of about 210,566 (311)
Plant small nuclear RNAs. IV. The structure of U1 RNA fromChlorella saccharophila: a phylogenetic support, in terms of RNA structure, for the probable interaction between U1 and U2 and RNPs during the splicing of pre-mRNA [PDF]
, 1988 Tamás Kiss +3 more
openalex +1 more source
Advanced Science, EarlyView.Current preclinical studies of AAV‐mediated gene therapy explore different strategies based on the characteristics of inner ear diseases. For genetic hearing loss, approaches include the replacement of a “good gene,” removal of a “bad gene,” or direct correction of mutations through base editing.
Fan Wu +7 more
wiley +1 more source
Control of adenovirus E1B mRNA synthesis by a shift in the activities of RNA splice sites.
, 1984 Craig Montell +3 more
openalex +1 more source
Advanced Science, EarlyView.Treatment of MPTP‐incubated cells with NAD+‐boosters increase the UPRmt/mitophagy‐related mitochondria quality control (MQC). Disturbed plasma UPRmt‐mitophagy‐mediated MQC profiles in PD patient samples. NMN inhibits motor deficit and forestalls neuropathology phenotypes of PD mice, which is required the atf4‐medicated UPRmt pathway.
Shuoting Zhou +16 more
wiley +1 more source
Advanced Science, EarlyView.Overview of the Genetic Deafness Commons (GDC), integrating data from the Chinese Deafness Genetics Consortium (CDGC) and 51 public databases. The GDC provides tools for variant search, functional predictions, and gene‐disease visualization, offering insights into 201 hearing loss genes and facilitating novel gene discovery and clinical applications ...
Hui Cheng +11 more
wiley +1 more source
Simian virus 40-rabbit beta-globin recombinants lacking late mRNA splice sites express cytoplasmic RNAs with altered structures [PDF]
, 1982 Roger White +2 more
openalex +1 more source
Advanced Science, EarlyView.METTL14/IGF2BP2‐mediated m6A modification drives LINC01094 upregulation in BC. Then, LINC01094 interacts with PKM2 monomers to promote their dimerization, while serving as a flexible scaffold to facilitate the assembly of the PKM2/JMJD5 complex, synergistically stabilizing PKM2 dimers and enhancing their nuclear translocation.
Mengqi Wang +8 more
wiley +1 more source
Rational Design of Inner Ear Drug Delivery Systems
Advanced Science, EarlyView.Hearing loss is a common disease affecting many people, and inner ear lesions are one of the most important causes. This review focuses on the treatment of inner ear hearing loss by drug delivery systems. It includes the current methods and technologies developed, and it predicts possible directions.
Xiayidan Maimaitikelimu +5 more
wiley +1 more source
Nonsense mutations inhibit splicing of MVM RNA in cis when they interrupt the reading frame of either exon of the final spliced product. [PDF]
, 1992 Lisa K. Naeger +4 more
openalex +1 more source