Results 121 to 130 of about 375,320 (335)

Impact of Alternative Splicing on the Human Proteome

Cell Reports, 2017
Summary: Alternative splicing is a critical determinant of genome complexity and, by implication, is assumed to engender proteomic diversity. This notion has not been experimentally tested in a targeted, quantitative manner.
Yansheng Liu, Mar Gonzàlez-Porta, Sergio Santos, Alvis Brazma, John C. Marioni, Ruedi Aebersold, Ashok R. Venkitaraman, Vihandha O. Wickramasinghe   +7 more
doaj   +1 more source

Identification of novel alternative splicing biomarkers for breast cancer with LC/MS/MS and RNA-Seq

BMC Bioinformatics, 2020
Background Alternative splicing isoforms have been reported as a new and robust class of diagnostic biomarkers. Over 95% of human genes are estimated to be alternatively spliced as a powerful means of producing functionally diverse proteins from a single
Fan Zhang, Chris K. Deng, Mu Wang, Bin Deng, Robert Barber, Gang Huang   +5 more
doaj   +1 more source

An Exonic Splicing Enhancer within a Bidirectional Coding Sequence Regulates Alternative Splicing of an Antisense mRNA [PDF]

, 2010
The discovery of increasing numbers of genes with overlapping sequences highlights the problem of expression in the context of constraining regulatory elements from more than one gene.
Hastings, Michelle Laura, Munroe, Stephen, Rediske, Nathaniel W., Salato, Valerie K., Zhang, Chao   +4 more
core   +1 more source

Corepressor diversification by alternative mRNA splicing is species specific. [PDF]

, 2016
BackgroundSMRT and NCoR are corepressor paralogs that help mediate transcriptional repression by a variety of transcription factors, including the nuclear hormone receptors.
Goodson, Michael L, Privalsky, Martin L, Snyder, Chelsea A   +2 more
core   +2 more sources

HIV RNA splicing

HIV & AIDS Review, 2011
Abstract RNA splicing is one of the most important events of pre-RNA maturation. Pre-RNA transcript may be spliced in several different ways, allowing a single viral gene to encode multiple proteins. The retroviral life cycle requires that significant amounts of RNA remain unspliced and perform many function in the cytoplasm.
Arleta Kowala-Piaskowska, Beata Bolewska, Maciej Bura, Iwona Mozer-Lisewska, Katarzyna Hryckiewicz   +4 more
openaire   +2 more sources

Systemic T Cell Receptor Profiling Reveals Adaptive Immune Activation and Potential Immune Signatures of Diagnosis and Brain Atrophy in Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Epilepsy is increasingly associated with immune dysregulation and inflammation. The T cell receptor (TCR), a key mediator of adaptive immunity, shows repertoire alterations in various immune‐mediated diseases. The unique TCR sequence serves as a molecular barcode for T cells, and clonal expansion accompanied by reduced overall TCR ...
Yong‐Won Shin, Sang Bin Hong, Yong Woo Shin, Inpyeong Hwang, Jaeseong Oh, Jihyeon Choi, Narae Kim, Jangsup Moon, Keun‐Hwa Jung, Kyung‐Il Park, Ki‐Young Jung, Kon Chu, Sang Kun Lee   +12 more
wiley   +1 more source

Murine leukemia virus RNA dimerization is coupled to transcription and splicing processes

Retrovirology, 2010
Most of the cell biological aspects of retroviral genome dimerization remain unknown. Murine leukemia virus (MLV) constitutes a useful model to study when and where dimerization occurs within the cell.
Maurel Stéphan, Mougel Marylène
doaj   +1 more source

Evidence for a nuclear compartment of transcription and splicing located at chromosome domain boundaries [PDF]

, 1993
The nuclear topography of splicing snRNPs, mRNA transcripts and chromosome domains in various mammalian cell types are described. The visualization of splicing snRNPs, defined by the Sm antigen, and coiled bodies, revealed distinctly different ...
A Monneron, A Schneider-G�dicke, AK Raap, B Roggenbuck, C Benyajati, C Collins, C Cremer, C Zorn, CA Ascoli, D Pinkel, D Pinkel, DE Comings, DJ Arndt-Jovin, DL Spector, DL Spector, DL Spector, DL Spector, DL Spector, DM Shotton, EA Lerner, G Blobel, GJ Brakenhoff, HTM Voort Van der, I Raska, J Bradl, JB Lawrence, JD Northway, JG Gall, JR Paulson, KC Carter, L Manuelidis, L Manuelidis, L Manuelidis, L Manuelidis, LEC Andrade, M Bachmann, M Bouteille, M Carmo-Fonseca, M Carmo-Fonseca, M Carmo-Fonseca, M Carmo-Fonseca, M Hochstrasser, M Mattioli, M Schardin, N Hutchison, P Lichter, P Lichter, P Lichter, P Lichter, R Berezney, R Reuter, R Verheijen, S Fakan, S Fakan, S Huang, SA Berman, T Cremer, T Cremer, TM Jovin, U Bond, U Nyman, Y Hiraoka, y Ramon, Y Xing, Y Xing   +64 more
core   +1 more source

SNUPN‐Related Muscular Dystrophy: Novel Phenotypic, Pathological and Functional Protein Insights

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective SNUPN‐related muscular dystrophy or LGMDR29 is a new entity that covers from a congenital or childhood onset pure muscular dystrophy to more complex phenotypes combining neurodevelopmental features, cataracts, or spinocerebellar ataxia. So far, 12 different variants have been described.
Nuria Muelas, Pablo Iruzubieta, Alberto Damborenea, Laura Pérez‐Fernández, Inmaculada Azorín, Juan Carlos Jiménez García, Ana Töpf, Pilar Martí, Lorena Fores‐Toribio, María Manterola, Rosana Blanco‐Mañez, Oihane Pikatza‐Menoio, Sonia Alonso‐Martín, Volker Straub, Aitziber L. Cortajarena, Adolfo López de Munain, David De Sancho, Lorea Blázquez, Juan J. Vilchez   +18 more
wiley   +1 more source

Dysregulation and Therapeutic Targeting of RNA Splicing Variants in Cancer [PDF]

مجلة جامعة النجاح للأبحاث العلوم الطبيعية
mRNA splicing constitutes a crucial biological phenomenon characterized by the excision of introns from pre-mRNA, followed by the synthesis of mature mRNA through the concatenation of the remaining exons.
Doaa Rabaya, Ghaleb Adwan
doaj   +1 more source