Results 131 to 140 of about 1,142,692 (261)
Advanced Science, EarlyView.The study identifies a novel circular RNA derived from the TP53 gene (circTP53), which is upregulated in HNSCC and correlates with poor patient prognosis. It demonstrates that circTP53 promotes HNSCC progression by interacting with USP10, stabilizing both proteins, enhancing deubiquitination of p53, and thereby influencing tumor growth, with its ...
Yin Wang +11 more
wiley +1 more source
CIRCexplorer3: A CLEAR Pipeline for Direct Comparison of Circular and Linear RNA Expression
Genomics, Proteomics & Bioinformatics, 2019 Sequences of circular RNAs (circRNAs) produced from back-splicing of exon(s) completely overlap with those from cognate linear RNAs transcribed from the same gene loci with the exception of their back-splicing junction (BSJ) sites. Therefore, examination
Xu-Kai Ma +6 more
doaj
RNA editing at a splicing site of NADH dehydrogenase subunit IV gene transcript in wheat mitochondria [PDF]
, 1989 Lorenzo Lamattina +2 more
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Advanced Science, EarlyView.This study reveals that M2‐EVs mitigate periodontitis‐induced bone resorption by modulating neutrophil fate. Single‐cell RNA sequencing identified an Anxa1hi neutrophil subpopulation with pro‐reparative properties. M2‐EVs disrupt neutrophil maturation, promoting this subpopulation through key reprogramming genes (Acvrl1, Fpr2). These findings highlight
Yufei Yao +7 more
wiley +1 more source
Collaborative Duality of CircGLIS3(2) RNA and Protein in human Wound Repair
Advanced Science, EarlyView.CircGLIS3(2), a circRNA transiently upregulated in dermal fibroblasts during acute wound healing, is induced by IL‐1α and TGF‐β. Its RNA activates fibroblasts into matrix‐secreting cells, while its encoded protein enhances proliferation. The RNA stabilizes PCOLCE, and the protein interacts with BTF3, collectively accelerating wound repair. Abstract The
Guanglin Niu +20 more
wiley +1 more source
A splice junction deletion deficient in the transport of RNA does not polyadenylate nuclear RNA. [PDF]
, 1983 Luis P. Villarreal, R T White
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Advanced Science, EarlyView.This study reveals that cytoplasmic PABPN1 is essential for mouse oocyte meiotic maturation by coordinating polyadenylation, translation, and degradation of maternal mRNAs. Pabpn1 knockout disrupts CDK1 activation, spindle formation, and chromosome alignment by impairing maturation‐promoting factor (MPF) regulation and BTG4‐mediated deadenylation ...
Xing‐Xing Dai +9 more
wiley +1 more source
Computational and Structural Biotechnology Journal, 2020 Alternative splicing of RNAs generates isoform diversity, resulting in different proteins that are necessary for maintaining cellular function and identity.
Wei Xiong Wen +2 more
doaj
Plant small nuclear RNAs. IV. The structure of U1 RNA fromChlorella saccharophila: a phylogenetic support, in terms of RNA structure, for the probable interaction between U1 and U2 and RNPs during the splicing of pre-mRNA [PDF]
, 1988 Tamás Kiss +3 more
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Advanced Science, EarlyView.Nanopriming enhances plant resilience to environmental challenges; however, its effectiveness across diverse genetic backgrounds, including genetic modifications and natural variations, remains uncertain. These findings demonstrate that nanopriming improves efficacy when natural genetic variations are considered, particularly in genetically modified ...
Yining Wu +4 more
wiley +1 more source