Results 131 to 140 of about 1,384,640 (333)

Loss of the RNA trimethylguanosine cap is compatible with nuclear accumulation of spliceosomal snRNAs but not pre-mRNA splicing or snRNA processing during animal development

, 2020
Lin Cheng, Yu Zhang, Yi Zhang, Tao Chen, Yong-Zhen Xu, Yikang S. Rong   +5 more
openalex   +2 more sources

Interpretation of BRCA2 Splicing Variants: A Case Series of Challenging Variant Interpretations and the Importance of Functional RNA Analysis [PDF]

, 2021
Paola Nix, Erin Mundt, Bradford Coffee, Elizabeth Goossen, Bryan M. Warf, Krystal Brown, Karla R. Bowles, Benjamin B. Roa   +7 more
openalex   +1 more source

Construction of a Multitissue Cell Atlas Reveals Cell‐Type‐Specific Regulation of Molecular and Complex Phenotypes in Pigs

Advanced Science, EarlyView.
This research conducts an in‐depth investigation of cell‐type‐specific regulatory mechanisms underlying molecular and complex phenotypes through integrative analysis of multitissue single‐nucleus RNA sequencing, bulk RNA‐seq, and genome‐wide association study (GWAS) data in pigs.
Lijuan Chen, Houcheng Li, Jinyan Teng, Zhen Wang, Xiaolu Qu, Zhe Chen, Xiaodian Cai, Haonan Zeng, Zhonghao Bai, Jinghui Li, Xiangchun Pan, Leyan Yan, Fei Wang, Lin Lin, Yonglun Luo, Goutam Sahana, Mogens Sandø Lund, Maria Ballester, Daniel Crespo‐Piazuelo, Peter Karlskov‐Mortensen, Merete Fredholm, Alex Clop, Marcel Amills, Crystal Loving, Christopher K. Tuggle, Ole Madsen, Jiaqi Li, Zhe Zhang, George E. Liu, Jicai Jiang, Lingzhao Fang, Guoqiang Yi   +31 more
wiley   +1 more source

Lamin B1 regulates RNA splicing factor expression by modulating the spatial positioning and chromatin interactions of the ETS1 gene locus

Animal Cells and Systems
Lamin B1, a crucial component of the nuclear lamina, plays a pivotal role in chromatin organization and transcriptional regulation in eukaryotic cells. While recent studies have highlighted the connection between Lamin B1 and RNA splicing regulation, the
Geun-Seup Shin, Ah-Ra Jo, Jinho Kim, Ji-Young Kim, Chul-Hong Kim, Mi-Jin An, Hyun-Min Lee, Yuna Park, Yujeong Hwangbo, Jung-Woong Kim   +9 more
doaj   +1 more source

LINE-1 RNA splicing and influences on mammalian gene expression [PDF]

, 2006
Victoria P. Belancio
openalex   +1 more source

Splice site m6A methylation prevents binding of U2AF35 to inhibit RNA splicing

Cell, 2021
M. Mendel, Kamila Delaney, R. R. Pandey, Kuan-Ming Chen, Joanna M. Wenda, C. Vågbø, F. Steiner, D. Homolka, R. Pillai   +8 more
semanticscholar   +1 more source

CircSMEK1 Suppresses HCC via the hnRNPK‐IGF2‐AKT Axis: A Diagnostic Biomarker and Therapeutic Target

Advanced Science, EarlyView.
CircSMEK1 is downregulated in MASH/HCC and predicts poor prognosis. It suppresses tumor progression by promoting hnRNPK ubiquitination and inhibiting the IGF2/PI3K/AKT axis, while its loss activates immunosuppressive cancer‐associated fibroblasts. Serum circSMEK1 serves as a non‐invasive diagnostic biomarker, and its restoration potently inhibits HCC ...
Peilan Guo, Xiaomeng Jia, Shenghong Wang, Xinyu Li, Yajing Liu, Lisen Lin, Zhengkun Wang, Fujun Liu, Slawomir Wolczynski, Nafis Rahman, Jie Gao, Xuguang Du, Suk‐Ying Tsang, Jiali Liu, Wei Song, Xiangdong Li   +15 more
wiley   +1 more source

Region-specific alternative splicing in the nervous system: Implications for regulation by the RNA-binding protein NAPOR [PDF]

, 2002
Wenqing Zhang, Haiying Liu, Kyoungha Han, Paula J. Grabowski   +3 more
openalex   +1 more source

Mechanisms of alternative pre-messenger RNA splicing.

Annual Review of Biochemistry, 2003
D. Black
semanticscholar   +1 more source

Pathogenicity of Mediator Complex Subunit 27 (MED27) in a Neurodevelopmental Disorder with Cerebellar Atrophy

Advanced Science, EarlyView.
MED27 is one of the 26 subunits in the human Mediator complex (MED). Neurodevelopmental disorder‐causing MED27 genetic variants induce instability of MED, leading to disrupted DNA occupancy, altered chromatin interaction, and subsequent transcriptional dysregulation of critical downstream genes, including master regulatory transcription factors ...
Nuermila Yiliyaer, Xiaocheng Li, Tianyu Guo, Haiying Zhou, Lihai Gong, Luowei Yuan, Yang Fu, Yulong Qiao, Ying Lam Lui, Nuo Chen, Pengfei Lin, Hoi Hung Cheung, Ho Ko, Linyan Meng, Xiao Chen, Yong Lei, Kin Ming Kwan, Huating Wang, Shen Gu   +18 more
wiley   +1 more source