Results 191 to 200 of about 1,142,692 (261)
Advanced Science, EarlyView.This study reveals a new mechanism by which PDIA3P1 regulates the progression of esophageal squamous cell carcinoma (ESCC). PDIA3P1 upregulates the expression of GLUT1 and HK2, promoting glycolysis and lactate production. Lactate upregulates the lactylation level of histone H4K8 and activates the transcription of target gene BMP7, ultimately ...
Tao Huang +13 more
wiley +1 more source
Comprehensive genetic analysis of poorly differentiated gastric cancer in young females
Annals of Gastroenterological Surgery, EarlyView.Although the involvement of female sex hormones in the development of poorly differentiated gastric cancer in young females is controversial, our detailed analysis using RNA‐seq suggested that the female sex hormone, β‐estradiol plays a role in the development of poorly differentiated gastric cancer in young females. Abstract Aim The reasons behind the
Nobuhiro Nakazawa +9 more
wiley +1 more source
The Role of Intron Structures in trans-Splicing and Cap 4 Formation for the LeishmaniaSpliced Leader RNA [PDF]
, 1999 Nancy R. Sturm, David A. Campbell
openalex +1 more source
m6A Modulates RAN Translation From CAG Repeat Expansion RNA
Aggregate, EarlyView.We described a novel role of N6‐methyladenosine in promoting non‐canonical repeat‐associated non‐AUG translation from CAG repeat expansion RNA. ABSTRACT Nucleotide repeat expansions contribute to the development of a number of neurodegenerative diseases.
Yuxiang Sun +3 more
wiley +1 more source
Chemical shift perturbation studies of the interactions of the second RNA‐binding domain of the Drosophila sex‐lethal protein with the transformer pre‐mRNA polyuridine tract and 3′ splice‐site sequences [PDF]
, 1999 Seung‐Wook Chi +8 more
openalex +1 more source
American Journal of Medical Genetics Part A, EarlyView.ABSTRACT Uniparental disomy (UPD) is a rare phenomenon in which both copies of a chromosome are inherited from a single parent. This can lead to genomic imprinting disorders and recessive disorders due to the presence of recessive pathogenic variants in both alleles. Additionally, depending on the mechanisms by which UPD occurs, mosaic aneuploidies may
Marta Carreño‐Hidalgo +4 more
wiley +1 more source
Regulation of human insulin receptor RNA splicing invivo.
, 1994 Svante Norgren +4 more
openalex +1 more source
Spliced exons of adenovirus late RNAs colocalize with snRNP in a specific nuclear domain. [PDF]
, 1996 Eileen Bridge +3 more
openalex +1 more source
A Splice‐Region Variant Causes an Atypical Presentation of GNAS Inactivation Disorder
American Journal of Medical Genetics Part A, EarlyView.ABSTRACT Pathogenic variants in GNAS can cause a wide range of diseases including pseudohypoparathyroidism, pseudopseudohypoparathyroidism, McCune‐Albright syndrome, among others. The specific phenotypic features that may be seen are influenced by the variant type and location in the gene, whether it causes loss or gain of function, and whether it is ...
Brandon S. Stone +11 more
wiley +1 more source