Results 191 to 200 of about 384,167 (334)

The Mitochondrial Tyrosyl-tRNA Synthetase of Podospora anserina Is a Bifunctional Enzyme Active in Protein Synthesis and RNA Splicing

, 1992
Ute Kämper, Ulrich Kück, Andrew D. Cherniack, Alan M. Lambowitz   +3 more
openalex   +2 more sources

Additional file 16 of Splicing factor derived circular RNA circCAMSAP1 accelerates nasopharyngeal carcinoma tumorigenesis via a SERPINH1/c-Myc positive feedback loop

, 2022
Yian Wang, Qijia Yan, Yongzhen Mo, Yuhang Liu, Yumin Wang, Shanshan Zhang, Can Guo, Fuyan Wang, Guiyuan Li, Zhaoyang Zeng, Wei Xiong   +10 more
openalex   +1 more source

Endocytic Control of Cell‐Autonomous and Non‐Cell‐Autonomous Functions of p53

Advanced Science, EarlyView.
NUMB Ex3‐containing isoforms localize to the plasma membrane, where they recruit p53 through SNX9 and direct it to multivesicular bodies and exosomes. Exported p53 is taken up by neighboring cells and activates nuclear programs, revealing an intercellular, exosome‐based pathway that might help establish a tumor‐suppressive microenvironment.
Roberta Cacciatore, Andrea Basile, Stefano Freddi, Irene Schiano Lomoriello, Carlo Ribelle Zucca, Giuseppe Ciossani, Luigi Scietti, Alessandro Cuomo, Simona Ronzoni, Simone Pelicci, Mario Faretta, Elena Zaccheroni, Giuliana Pelicci, Vittoria Matafora, Angela Bachi, Rosalind Helen Gunby, Salvatore Pece, Sara Sigismund, Letizia Lanzetti, Ivan Nicola Colaluca, Pier Paolo Di Fiore   +20 more
wiley   +1 more source

An RNA splicing system that excises DNA transposons from animal mRNAs. [PDF]

Nature
Zhao LW, Nardone C, Chang C, Paulo JA, Elledge SJ, Kennedy S.   +5 more
europepmc   +1 more source

Palmitoylation‐Mediated Ubiquitination of SRPK1 Regulates Ferroptosis in High‐Fat‐Induced Erectile Dysfunction

Advanced Science, EarlyView.
Elevated exogenous palmitic acid promotes the S‐palmitoylation of SRPK1 in endothelial cells, a dynamic process governed by ZDHHC24 and APT1. This post‐translational modification strengthens the interaction between SRPK1 and the E3 ubiquitin ligase MIB1, thereby facilitating the proteasomal degradation of SRPK1.
Xiao‐Hui Tan, Ke‐Fan Li, Yi‐Ming Yuan, Man‐Cheng Xia, Fang‐Zhou Zhao, Hong‐Gang Ying, Zhuo Zhou, Peng‐Chao Gao, Guo‐Qing Xie, Xue‐Song Li, Hui Jiang, Rui‐Li Guan   +11 more
wiley   +1 more source

Unraveling the FGFR-RNA splicing axis: Mechanisms, oncogenic crosstalks and innovations for therapeutic purpose. [PDF]

Acta Pharm Sin B
Xian X, Gong R, Rong S, Zhang Z, Jia F, Li L, Chen Z, Eymin B, Jia T.   +8 more
europepmc   +1 more source

Engineered GM1 Intersects Between Mitochondrial and Synaptic Pathways to Ameliorate ALS Pathology

Advanced Science, EarlyView.
Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease driven by genetic and molecular disruptions affecting energy balance, protein homeostasis, and stress responses in nerve cells. Studies using human and rodent models identified convergent defects in mitochondria and synaptic function.
Federica Pilotto, Tristan Dellazizzo Toth, Silvano Bond, Alexander Schmitz, Rim Diab, Sara Y. Ngo Tenlep, Brian Mooney, Silvia Erni, Martina Schobesberger, Olivier Scheidegger, Camille Peitsch, Smita Saxena   +11 more
wiley   +1 more source

A study of RNA splicing and protein expression in the living human brain. [PDF]

PLoS One
Kopell BH, Kaji DA, Liharska LE, Vornholt E, Lund A, Hashemi A, Thompson RC, Johnson JS, Bussola N, Cheng E, Park YJ, Shah P, Ma W, Searfoss R, Miller GM, Chand NM, Humphrey J, Wilkins L, Ziafat K, Silk H, Linares LM, Sullivan B, Feng C, Cohen V, Kota P, Moya E, Rieder MK, Nadkarni GN, Breen MS, Scarpa J, Narain NR, Wang P, Kiebish MA, Schadt EE, Beckmann ND, Charney AW.   +35 more
europepmc   +1 more source

Connexin 26 Functions as a Direct Transcriptional Regulator During the Cochlea Development

Advanced Science, EarlyView.
Connexin26 can not only form intercellular channels that mediate rapid communication on the cell membrane, but also enter the nucleus as a transcription factor to directly regulate the transcription of nuclear genes. In the developing cochlea, Cx26 can control the maturation of the molecular scissor ADAM10 by regulating the transcription of TspanC8 ...
Xiaozhou Liu, Le Xie, Yuan Jin, Sen Chen, Xinyu Shi, Yanjun Zong, Zhengdong Zhao, Wei‐Jia Kong, Yu Sun   +8 more
wiley   +1 more source

A deep dive into statistical modeling of RNA splicing QTLs reveals variants that explain neurodegenerative disease. [PDF]

Am J Hum Genet
Wang D, Gazzara MR, Jewell S, Wales-McGrath BD, Yang K, Brown CD, Choi PS, Barash Y.   +7 more
europepmc   +1 more source