Results 211 to 220 of about 225,841 (261)

RPL22 links ribosome biogenesis, RNA splicing, and sensitivity to RNA polymerase I inhibition. [PDF]

Cell Chem Biol
Weis K, Abdel-Wahab O.
europepmc   +1 more source

NAD⁺ reverses Alzheimer's neurological deficits via regulating differential alternative RNA splicing of <i>EVA1C</i>. [PDF]

Sci Adv
Ai R, Mao L, Jin X, Campos-Marques C, Zhang SQ, Pan J, Lagartos-Donate MJ, Cao SQ, Barros-Santos B, Nóbrega-Martins R, Katsaitis F, Yang G, Xie C, Kang X, Wang P, Novello M, Hu Y, Bergersen LH, Storm-Mathisen J, Kuroyanagi H, Escobar-Doncel B, González NV, Chaudhry FA, Wang Z, Zhang Q, Lu G, Sotiropoulos I, Niu Z, Chen G, Nair RR, Silva JM, Luo OJ, Fang EF.   +32 more
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USP39 at the crossroads of cancer immunity: regulating immune evasion and immunotherapy response through RNA splicing and ubiquitin signaling. [PDF]

Front Immunol
Zhou F, Li X, Sun Y, Wang Y, Niu K, Gao X, Zhang J, Chen T, Li Y, Zhao W, Mao B, Xu Q, Shi Y, He Z.   +13 more
europepmc   +1 more source

The AMPK-related kinase NUAK1 regulates neuronal morphogenesis through the RNA splicing co-factor SON

Kerkhofs M, Meyer-Dilhet G, Polvèche H, Yandiev S, Tait-Mulder J, Lilla S, Sumpton D, Murphy DJ, Ahn EE, Bourgeois CF, Goillot E, Courchet J.   +11 more
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Inhibition of Pf CLK3 a master regulator of malaria parasite RNA-splicing provides the basis for a radical cure for malaria

Janha O, Olaniyan N, Diam GK, Sharma S, Beraldi D, Jamieson AG, Bozdech Z, Tobin AB, Modrzynska K.   +8 more
europepmc   +1 more source

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RNA Splicing and Cancer

Trends in Cancer, 2020
RNA splicing is an essential process that governs many aspects of cellular proliferation, survival, and differentiation. Considering the importance of RNA splicing in gene regulation, alterations in this pathway have been implicated in many human cancers.
Eric, Wang, Iannis, Aifantis
openaire   +2 more sources

RNA Splicing by the Spliceosome

Annual Review of Biochemistry, 2020
The spliceosome removes introns from messenger RNA precursors (pre-mRNA). Decades of biochemistry and genetics combined with recent structural studies of the spliceosome have produced a detailed view of the mechanism of splicing. In this review, we aim to make this mechanism understandable and provide several videos of the spliceosome in action to ...
Wilkinson, Max E., Charenton, Clément, Nagai, Kiyoshi   +2 more
openaire   +2 more sources

RNA mis-splicing in disease [PDF]

Nature Reviews Genetics, 2015
The human transcriptome is composed of a vast RNA population that undergoes further diversification by splicing. Detecting specific splice sites in this large sequence pool is the responsibility of the major and minor spliceosomes in collaboration with numerous splicing factors.
Maurice Swanson, Swanson Maurice S
exaly   +3 more sources

RNA Splicing

Circulation Research, 2016
RNA splicing represents a post-transcriptional mechanism to generate multiple functional RNAs or proteins from a single transcript. The evolution of RNA splicing is a prime example of the Darwinian function follows form concept. A mutation that leads to a new mRNA (form) that encodes for a new functional protein (function) is likely to be retained, and
Esther E Creemers, Maarten Van Den Hoogenhof   +1 more
exaly   +3 more sources

RNA Splicing in the Chloroplast

2006
The chloroplast genomes of Chlamydomonas spp. contain introns that belong to the two major classes found in organelles: group I and group II. Some of the members of both classes are ribozymes capable of self-splicing in vitro and, indeed, most of the group I introns studied in Chlamydomonas spp. are autocatalyic.
Herrin, David L., Kuo, Tai-Chih, Goldschmidt-Clermont, Michel P.   +2 more
openaire   +1 more source