Results 201 to 210 of about 384,167 (334)

Regulation of Alternative RNA Splicing by Exon Definition and Exon Sequences in Viral and Mammalian Gene Expression

, 2004
Zhi‐Ming Zheng
openalex   +2 more sources

Quantitative Proteomics and CRISPR/Cas9 Editing Reveal UPR‐Mediated Control of Immunoglobulin Homeostasis in Hybridomas

Advanced Science, EarlyView.
BCR sequencing and subclone analysis correlated immunoglobulin (Ig) chain loss in dysfunctional hybridomas with disrupted monoclonal antibody homeostasis. Proteomics‐guided CRISPR/Cas9 editing revealed that the unfolded protein response (UPR) regulates aberrant Ig synthesis.
Rubing Zou, Xinying Lu, Ying Liu, Peiyu Yang, Shuo Sun, Yihua Liu, Yinyuan Mo, Guonian Zhu, Jae Seong Lee, Yirong Guo   +9 more
wiley   +1 more source

Visualizing RNA splicing [PDF]

Nature Reviews Molecular Cell Biology, 2013
openaire   +1 more source

Activation and Spatial Redistribution of RNA Splicing Factors Trigger Hepatic Regeneration. [PDF]

Cell Mol Gastroenterol Hepatol
An Y, Lian J, Wei W, Mao Y, Qiao L, Li T, Li R, Li S, Zhao S, Chen X, Zhao H, Hu H.   +11 more
europepmc   +1 more source

eLife assessment: Switching of RNA splicing regulators in immature neuroblasts during adult neurogenesis

Sofia J. Araújo
openalex   +1 more source

RNA Splicing Factor Mutations That Cause Retinitis Pigmentosa Result in Circadian Dysregulation

, 2019
Iryna Shakhmantsir, Scott Dooley, Siddharth Kishore, Dechun Chen, Eric A. Pierce, Jean Bennett, Amita Sehgal   +6 more
openalex   +2 more sources

Ir(III) Complexes Convert Cold to Hot Tumors via Ferroptosis/Necroptosis‐Driven Immunogenic Cell Death and Photosensitized CD47 Downregulation

Advanced Science, EarlyView.
Red‐light‐activated Ir1 overcomes hypoxia tolerance and adapts to the immunosuppressive tumor microenvironment, converting immunologically cold tumors into inflamed hot microenvironments. This conversion is driven by synergistic induction of immunogenic cell death through coordinated ferroptosis‐necroptosis pathways and spatiotemporally controlled ...
Long‐Bo Yu, Peng Wang, Qing‐Hua Shen, Qi‐Xin Guan, Zhi‐Yuan Li, Ying‐Ying Han, Xin‐Yi Zhang, Qing‐Yuan Hu, Cai‐Ping Tan   +8 more
wiley   +1 more source

MYC-mediated transcriptional control of splicing factors promotes RNA splicing in activated B lymphocytes. [PDF]

Sci Rep
Li S, Yang C, Li J, Liu Z, Gong F, Ke X, Ruan GX, Huang H.   +7 more
europepmc   +1 more source

The Long Noncoding RNA <i>Ctcflos</i> Orchestrates Transcriptional and Post-Transcriptional Alternative Splicing Programs Essential for Thermogenic Gene Expression in Brite Adipocytes

, 2020
Andrea Bast‐Habersbrunner, Christoph Kiefer, Peter Weber, Tobias Fromme, Anna Schießl, Petra Schwalie, Bart Deplancke, Yongguo Li, Martin Klingenspor   +8 more
openalex   +1 more source

PRDM1+ Malignant Cells Mediate an Immunosuppressive Landscape and Resistance to Neoadjuvant Chemoradiotherapy and Immunotherapy in Esophageal Squamous Cell Carcinoma

Advanced Science, EarlyView.
Integrated scRNA‐seq, scTCR‐seq analysis, and functional assays identify PRDM1+ malignant epithelial cells with hyper lipid peroxidation characteristics that demonstrate reduced responsiveness to the nICRT treatment. Principal factor PRDM1 activates cysteine metabolism genes to modulate lipid peroxidation (an intrinsic cellular pathway related to ...
Dijian Shen, Rui Li, Yong She, Xuefei Liu, Yuanyang Huang, Yongling Ji, Keying Chen, Zhengbo Song, Runzhe Chen, Xuan Li, Qi Zhao, Qixun Chen, Ming Chen   +12 more
wiley   +1 more source