Results 201 to 210 of about 208,055 (239)
Some of the next articles are maybe not open access.
1992
RNA trans-splicing joins two or more RNA molecules into one RNA molecule. This process is a variation of the more familiar and common intron removal during nuclear pre-mRNA splicing. Both splicing reactions are a series of cleavage and ligation reactions resulting in the precise excision of introns and in the joining of exons to generate mature RNA. In
David Hirsh, Xin-Yun Huang
openaire +3 more sources
RNA trans-splicing joins two or more RNA molecules into one RNA molecule. This process is a variation of the more familiar and common intron removal during nuclear pre-mRNA splicing. Both splicing reactions are a series of cleavage and ligation reactions resulting in the precise excision of introns and in the joining of exons to generate mature RNA. In
David Hirsh, Xin-Yun Huang
openaire +3 more sources
2012
Alternative splicing is a key element of eukaryotic gene expression. Almost all polymerase II transcripts are alternatively spliced. RNA is chemically and structurally more flexible than DNA, and can act as a catalyst. RNA is an active player in mediating genetic information, not just a static messenger.
BURATTI, EMANUELE +2 more
openaire +3 more sources
Alternative splicing is a key element of eukaryotic gene expression. Almost all polymerase II transcripts are alternatively spliced. RNA is chemically and structurally more flexible than DNA, and can act as a catalyst. RNA is an active player in mediating genetic information, not just a static messenger.
BURATTI, EMANUELE +2 more
openaire +3 more sources
RNA splicing in lower eukaryotes
Current Biology, 1992Recently, cis-acting elements and trans-acting RNA and protein factors necessary for splicing nuclear pre-mRNAs, group II introns or group III introns, have been discovered, and new roles for the splicing factors have been elucidated. Parallels among the pathways for splicing these different classes of introns have been identified.
John L. Woolford +2 more
openaire +3 more sources
Spliced leader RNA trans-splicing in metazoa
Parasitology Today, 1996Spliced leader trans-splicing is a form of RNA processing originally described and studied in parasitic kinetoplastida. This mechanism of gene expression also occurs in parasitic and free-living metazoa. In this review, Dick Davis describes current knowledge of the distribution, substrates, specificity and functional significance of trans-splicing in ...
openaire +3 more sources
Splicing of Messenger RNA Precursors
Science, 1987A general mechanism for the splicing of nuclear messenger RNA precursors in eukaryotic cells has been widely accepted. This mechanism, which generates lariat RNAs possessing a branch site, seems related to the RNA-catalyzed reactions of self-splicing introns.
openaire +4 more sources
Visualizing RNA splicing in vivo
Molecular BioSystems, 2007Ribozymes are RNA molecules capable of associating with other RNA molecules through base-pairing and catalyzing various reactions involving phosphate group transfer. Of particular interest to us is the well known ribozyme from Tetrahymena thermophila capable of catalyzing RNA splicing in eukaryotic systems, chiefly because of its potential use as a ...
Gayatri Gowrishankar, Jianghong Rao
openaire +3 more sources
RNA Splicing: Activity in the spliceosome
Current Biology, 1994In the active spliceosome, U2, U5 and U6 small nuclear RNAs form a network of interactions with the RNA substrate. U6 snRNA is closely implicated in the catalysis of splicing.
openaire +3 more sources
RNA Trans-Splicing for Genodermatoses
2012Spliceosome-mediated RNA trans-splicing (SMaRT) is a tool that facilitates the recombination of two distinct pre-mRNA molecules. Its application for gene therapeutic purposes has been hindered by laborious procedures to identify gene-specific molecules.
Ulrich Koller +3 more
openaire +3 more sources
Splice site m6A methylation prevents binding of U2AF35 to inhibit RNA splicing
Cell, 2021Kamila Delaney +2 more
exaly