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RNA splicing promotes translation and RNA surveillance
Nature Structural & Molecular Biology, 2005Aberrant mRNAs harboring premature termination codons (PTCs or nonsense codons) are degraded by the nonsense-mediated mRNA decay (NMD) pathway. mRNAs transcribed from genes that naturally acquire PTCs during lymphocyte development are strongly downregulated by PTCs.
Jayanthi P, Gudikote +3 more
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RNA splicing in lower eukaryotes
Current Biology, 1992Recently, cis-acting elements and trans-acting RNA and protein factors necessary for splicing nuclear pre-mRNAs, group II introns or group III introns, have been discovered, and new roles for the splicing factors have been elucidated. Parallels among the pathways for splicing these different classes of introns have been identified.
J L, Woolford, C L, Peebles
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Visualizing RNA splicing in vivo
Molecular BioSystems, 2007Ribozymes are RNA molecules capable of associating with other RNA molecules through base-pairing and catalyzing various reactions involving phosphate group transfer. Of particular interest to us is the well known ribozyme from Tetrahymena thermophila capable of catalyzing RNA splicing in eukaryotic systems, chiefly because of its potential use as a ...
Gayatri, Gowrishankar, Jianghong, Rao
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Circulation Research, 2016
RNA splicing represents a post-transcriptional mechanism to generate multiple functional RNAs or proteins from a single transcript. The evolution of RNA splicing is a prime example of the Darwinian function follows form concept. A mutation that leads to a new mRNA (form) that encodes for a new functional protein (function) is likely to be retained, and
Maarten M G, van den Hoogenhof +2 more
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RNA splicing represents a post-transcriptional mechanism to generate multiple functional RNAs or proteins from a single transcript. The evolution of RNA splicing is a prime example of the Darwinian function follows form concept. A mutation that leads to a new mRNA (form) that encodes for a new functional protein (function) is likely to be retained, and
Maarten M G, van den Hoogenhof +2 more
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Splicing of Messenger RNA Precursors
Science, 1987A general mechanism for the splicing of nuclear messenger RNA precursors in eukaryotic cells has been widely accepted. This mechanism, which generates lariat RNAs possessing a branch site, seems related to the RNA-catalyzed reactions of self-splicing introns.
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Cellular functions of eukaryotic RNA helicases and their links to human diseases
Nature Reviews Molecular Cell Biology, 2023Katherine E Bohnsack +2 more
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RNA contributions to the form and function of biomolecular condensates
Nature Reviews Molecular Cell Biology, 2020Amy S Gladfelter
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