Results 221 to 230 of about 384,167 (334)

<i>FIR/PUF60</i>: Multifunctional Molecule Through RNA Splicing for Revealing the Novel Disease Mechanism and Effective Individualized Therapies. [PDF]

Int J Mol Sci
Matsushita K, Kitamura K, Tanaka N, Kobayashi S, Suenaga Y, Hoshino T.   +5 more
europepmc   +1 more source

Irregular RNA splicing curtails postsynaptic gephyrin in the cornu ammonis of patients with epilepsy [PDF]

, 2010
Benjamín Förstera, Abdel Ali Belaidi, René Jüttner, Carola Bernert, Michael Tsokos, T.-N. Lehmann, Peter A. Horn, Christoph Dehnicke, Günter Schwarz, Jochen C. Meier   +9 more
openalex   +1 more source

Tobacco Smoke Exposure From Prenatal To Adolescent Periods Drives IBD Pathogenesis: Dynamic DNA Methylation Signatures Across Lifespan Stages

Advanced Science, EarlyView.
This study illustrates that maternal smoking during pregnancy (MSDP) is an independent risk factor for IBD in offspring, and DNA methylation serves as a key mechanistic pathway connecting early‐life smoking exposure with IBD risk in offspring. That highlights the urgent need for preventive interventions targeting prospective parents and minors to ...
Han Zhang, Jianhui Zhao, Jie Chen, Xinyi Ma, Siyun Zhou, Alexandra Noble, Rahul Kalla, Judith Wellens, Kun Liu, Evropi Theodoratou, Jack Satsangi, Xue Li   +11 more
wiley   +1 more source

Regulation of RNA splicing in endometrial tissue and its association with endometriosis. [PDF]

iScience
Yang F, Qi T, McRae AF, Rogers PAW, Montgomery GW, Mortlock S.   +5 more
europepmc   +1 more source

Stochastic principles governing alternative splicing of RNA

, 2017
Jianfei Hu, Eli Boritz, William Wylie, Daniel C. Douek   +3 more
openalex   +2 more sources

Alphaviral Capsid Proteins Inhibit Stress Granule Assembly via Competitive RNA Binding With G3BP1

Advanced Science, EarlyView.
Stress granules exert antiviral functions. This study illustrates a conserved function of alphaviral capsid proteins in modulating stress granules. Oligomerization mediated by a helical motif coupled with a positively charged intrinsically disordered region (IDR) directly competes with G3BP1 for RNA binding, thereby disrupting G3BP1‐RNA liquid–liquid ...
Yun Zhang, Yi Liu, Zhiying Yao, Haolong Lai, Xiaoxin Chen, Ziqiu Wang, Yiqiong Bao, Tingting Li, Xiaoming Zhou, Xiabin Chen, Peiguo Yang   +10 more
wiley   +1 more source

Alternative RNA splicing: contribution to pain and potential therapeutic strategy

, 2016
Lucy F. Donaldson, Nicholas Beazley‐Long   +1 more
openalex   +1 more source

Oncogenes and RNA splicing of human tumor viruses [PDF]

, 2014
Masahiko Ajiro, Zhi‐Ming Zheng
openalex   +1 more source

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

A trans-spliced telomerase RNA dictates telomere synthesis in Trypanosoma brucei [PDF]

, 2013
Ranjodh Sandhu, Samantha L. Sanford, Shrabani Basu, MinA Park, Unnati M. Pandya, Bibo Li, Kausik Chakrabarti   +6 more
openalex   +1 more source