Results 41 to 50 of about 1,384,640 (333)

Developments in RNA Splicing and Disease [PDF]

Cold Spring Harbor Perspectives in Biology, 2010
Pre-mRNA processing, including 5'-end capping, splicing, editing, and polyadenylation, consists of a series of orchestrated and primarily cotranscriptional steps that ensure both the high fidelity and extreme diversity characteristic of eukaryotic gene expression.
Michael G, Poulos, Ranjan, Batra, Konstantinos, Charizanis, Maurice S, Swanson   +3 more
openaire   +2 more sources

Incorporating evolutionary information and functional domains for identifying RNA splicing factors in humans. [PDF]

PLoS ONE, 2011
Regulation of pre-mRNA splicing is achieved through the interaction of RNA sequence elements and a variety of RNA-splicing related proteins (splicing factors).
Justin Bo-Kai Hsu, Neil Arvin Bretaña, Tzong-Yi Lee, Hsien-Da Huang   +3 more
doaj   +1 more source

AKT3-mediated IWS1 phosphorylation promotes the proliferation of EGFR-mutant lung adenocarcinomas through cell cycle-regulated U2AF2 RNA splicing

Nature Communications, 2021
IWS1 regulates multiple steps in RNA metabolism, including RNA elongation and alternative RNA splicing. Here the authors show that AKT3 phosphorylates IWS1, which alters U2AF2 RNA splicing and promotes growth of lung adenocarcinomas via a Sororin/ERK ...
Georgios I. Laliotis, Evangelia Chavdoula, Maria D. Paraskevopoulou, Abdul Kaba, Alessandro La Ferlita, Satishkumar Singh, Vollter Anastas, Keith A. Nair, Arturo Orlacchio, Vasiliki Taraslia, Ioannis Vlachos, Marina Capece, Artemis Hatzigeorgiou, Dario Palmieri, Christos Tsatsanis, Salvatore Alaimo, Lalit Sehgal, David P. Carbone, Vincenzo Coppola, Philip N. Tsichlis   +19 more
doaj   +1 more source

Alternative Splicing in Myeloid Malignancies

Biomedicines, 2021
Alternative RNA splicing (AS) is an essential physiologic function that diversifies the human proteome. AS also has a crucial role during cellular development.
Carmelo Gurnari, Simona Pagliuca, Valeria Visconte   +2 more
doaj   +1 more source

Impact of spliceosome mutations on RNA splicing in myelodysplasia: dysregulated genes/pathways and clinical associations.

Blood, 2018
SF3B1, SRSF2, and U2AF1 are the most frequently mutated splicing factor genes in the myelodysplastic syndromes (MDS). We have performed a comprehensive and systematic analysis to determine the effect of these commonly mutated splicing factors on pre-mRNA
A. Pellagatti, R. Armstrong, V. Steeples, E. Sharma, E. Repapi, Shalini Singh, Andrea Sanchi, A. Radujkovic, P. Horn, H. Dolatshad, Swagata Roy, J. Broxholme, H. Lockstone, S. Taylor, A. Giagounidis, P. Vyas, A. Schuh, A. Hamblin, E. Papaemmanuil, S. Killick, L. Malcovati, M. L. Hennrich, A. Gavin, A. Ho, T. Luft, E. Hellström-Lindberg, M. Cazzola, Christopher W. J. Smith, Stephen P Smith, J. Boultwood   +29 more
semanticscholar   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Use of a Fluorescent Aptamer RNA as an Exonic Sequence to Analyze Self-Splicing Ability of a Group I Intron from Structured RNAs

Biology, 2016
Group I self-splicing intron constitutes an important class of functional RNA molecules that can promote chemical transformation. Although the fundamental mechanism of the auto-excision from its precursor RNA has been established, convenient assay ...
Airi Furukawa, Takahiro Tanaka, Hiroyuki Furuta, Shigeyoshi Matsumura, Yoshiya Ikawa   +4 more
doaj   +1 more source

PCB: A pseudotemporal causality-based Bayesian approach to identify EMT-associated regulatory relationships of AS events and RBPs during breast cancer progression.

PLoS Computational Biology, 2023
During breast cancer metastasis, the developmental process epithelial-mesenchymal (EM) transition is abnormally activated. Transcriptional regulatory networks controlling EM transition are well-studied; however, alternative RNA splicing also plays a ...
Liangjie Sun, Yushan Qiu, Wai-Ki Ching, Pu Zhao, Quan Zou   +4 more
doaj   +1 more source

The K666N mutation in SF3B1 is associated with increased progression of MDS and distinct RNA splicing.

Blood Advances, 2020
The K666N mutation of SF3B1 has distinct clinicopathologic features in MDS. The K666N mutation of SF3B1 has a distinct RNA splicing profile.
W. Dalton, Eric Helmenstine, L. Pieterse, Bing Li, C. Gocke, J. Donaldson, Zhijian Xiao, L. Gondek, G. Ghiaur, I. Gojo, B. Smith, M. Levis, A. Dezern   +12 more
semanticscholar   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source