Results 41 to 50 of about 1,489,947 (420)

Cellular stress and RNA splicing [PDF]

Trends in Biochemical Sciences, 2009
In response to physical and chemical stresses that affect protein folding and, thus, the execution of normal metabolic processes, cells activate gene-expression strategies aimed at increasing their chance of survival. One target of several stressing agents is pre-mRNA splicing, which is inhibited upon heat shock.
Biamonti G, Caceres JF
openaire   +4 more sources

Mutations in the RNA splicing factor SF3B1 promote tumorigenesis through MYC stabilization.

Cancer Discovery, 2020
Although mutations in the RNA splicing factor SF3B1 are frequent in multiple cancers, their functional effects and therapeutic dependencies are poorly understood. Here we characterize 98 tumors and 12 isogenic cell lines harboring SF3B1 hotspot mutations,
Zhaoqi Liu, A. Yoshimi, Jiguang Wang, Hana Cho, Stanley Chun-Wei Lee, Michelle Ki, Lillian E Bitner, T. Chu, Harshal Shah, Bo Liu, A. Mato, P. Ruvolo, G. Fabbri, L. Pasqualucci, O. Abdel-Wahab, R. Rabadán   +15 more
semanticscholar   +1 more source

Saturation mutagenesis reveals manifold determinants of exon definition. [PDF]

, 2017
To illuminate the extent and roles of exonic sequences in the splicing of human RNA transcripts, we conducted saturation mutagenesis of a 51-nt internal exon in a three-exon minigene.
Anquetil, Vincent, Arias, Mauricio A., Chasin, Lawrence A., Ju, Jingyue, Kalachikov, Sergey, Ke, Shengdong, Maity, Alisha, Russo, James J, Yang, Anthony, Zamalloa, Jorge Rojas   +9 more
core   +2 more sources

Spliced leader RNA trans-splicing in dinoflagellates [PDF]

Proceedings of the National Academy of Sciences, 2007
Through the analysis of hundreds of full-length cDNAs from fifteen species representing all major orders of dinoflagellates, we demonstrate that nuclear-encoded mRNAs in all species, from ancestral to derived lineages, are trans-spliced with the addition of the 22-nt conserved spliced leader (SL), DCCGUAGCCAUUUUGGCUCAAG (D = U, A, or G), to the 5′ end.
Lilibeth Miranda, Yubo Hou, Terry Gaasterland, Nancy R. Sturm, Senjie Lin, David A. Campbell, Huan Zhang   +6 more
openaire   +3 more sources

ISVASE: identification of sequence variant associated with splicing event using RNA-seq data

BMC Bioinformatics, 2017
Background Exon recognition and splicing precisely and efficiently by spliceosome is the key to generate mature mRNAs. About one third or a half of disease-related mutations affect RNA splicing.
Hasan Awad Aljohi, Wanfei Liu, Qiang Lin, Jun Yu, Songnian Hu   +4 more
doaj   +1 more source

Approaches to link RNA secondary structures with splicing regulation [PDF]

Methods Mol Biol. 2014;1126:341-56, 2015
In higher eukaryotes, alternative splicing is usually regulated by protein factors, which bind to the pre-mRNA and affect the recognition of splicing signals. There is recent evidence that the secondary structure of the pre-mRNA may also play an important role in this process, either by facilitating or by hindering the interaction with factors and ...
arxiv   +1 more source

Intracerebral Hemorrhage and Ischemic Stroke of Different Etiologies Have Distinct Alternatively Spliced mRNA Profiles in the Blood: a Pilot RNA-seq Study. [PDF]

, 2015
Whole transcriptome studies have used 3'-biased expression microarrays to study genes regulated in the blood of stroke patients. However, alternatively spliced messenger RNA isoforms have not been investigated for ischemic stroke or intracerebral ...
Ander, Bradley P, Dykstra-Aiello, Cheryl, Ho, Carolyn, Hull, Heather, Jickling, Glen C, Liu, DaZhi, Orantia, Miles, Stamova, Boryana, Zhan, Xinhua   +8 more
core   +2 more sources

Alternative Splicing in Myeloid Malignancies

Biomedicines, 2021
Alternative RNA splicing (AS) is an essential physiologic function that diversifies the human proteome. AS also has a crucial role during cellular development.
Carmelo Gurnari, Simona Pagliuca, Valeria Visconte   +2 more
doaj   +1 more source

RNA Alternative Splicing Prediction with Discrete Compositional Energy Network [PDF]

arXiv, 2021
A single gene can encode for different protein versions through a process called alternative splicing. Since proteins play major roles in cellular functions, aberrant splicing profiles can result in a variety of diseases, including cancers. Alternative splicing is determined by the gene's primary sequence and other regulatory factors such as RNA ...
arxiv  

Writing a wrong: Coupled RNA polymerase II transcription and RNA quality control [PDF]

, 2019
Processing and maturation of precursor RNA species is coupled to RNA polymerase II transcription. Co-transcriptional RNA processing helps to ensure efficient and proper capping, splicing, and 3' end processing of different RNA species to help ensure ...
Hughes, Katlyn D., Mosley, Amber L., Peck, Sarah A., Victorino, Jose F.   +3 more
core   +1 more source