Results 51 to 60 of about 1,023,640 (307)
A Novel Intronic KMT2D Variant as a Cause of Kabuki Syndrome: A Case Report
The Application of Clinical Genetics, 2021 Erica Aristizábal,1 Lorena Diaz-Ordóñez,1 Estephania Candelo,1,2 Harry Pachajoa1,2 1Center for Research on Congenital Anomalies and Rare Diseases (CIACER), Department of Basic Medical Sciences, Universidad Icesi, Cali, Valle del Cauca, Colombia ...
Aristizábal E +3 more
doaj
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Splicing therapeutics in SMN2 and APOB [PDF]
, 2009 Splicing therapeutics are defined as the deliberate modification of RNA splicing to achieve therapeutic goals. Various techniques for splicing therapeutics have been described, and most of these involve the use of antisense oligonucleotide-based ...
Krainer, AR +3 more
core
Detecting differential usage of exons from RNA-Seq data [PDF]
, 2012 RNA-Seq is a powerful tool for the study of alternative splicing and other forms of alternative isoform expression. Understanding the regulation of these processes requires comparisons between treatments, tissues or conditions.
Simon Anders +2 more
core +1 more source
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Catalytic RNA and RNA Splicing [PDF]
American Zoologist, 1989 The capacity of Watson-Crick base-pair complementarity to direct informational transactions basic to gene expression has long been appreciated. Among RNA molecules, it mediates mRNA-tRNA codon-anticodon pairing and the 16S rRNA-mRNA Shine-Dalgarno interaction.
openaire +1 more source
Structural basis for the sequence-specific RNA-recognition mechanism of human CUG-BP1 RRM3 [PDF]
, 2009 The CUG-binding protein 1 (CUG-BP1) is a member of the CUG-BP1 and ETR-like factors (CELF) family or the Bruno-like family and is involved in the control of splicing, translation and mRNA degradation.
Kanako Kuwasako +27 more
core +2 more sources
Incorporating evolutionary information and functional domains for identifying RNA splicing factors in humans. [PDF]
PLoS ONE, 2011 Regulation of pre-mRNA splicing is achieved through the interaction of RNA sequence elements and a variety of RNA-splicing related proteins (splicing factors).
Justin Bo-Kai Hsu +3 more
doaj +1 more source
Alternative Splicing in Myeloid Malignancies
Biomedicines, 2021 Alternative RNA splicing (AS) is an essential physiologic function that diversifies the human proteome. AS also has a crucial role during cellular development.
Carmelo Gurnari +2 more
doaj +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source