Results 41 to 50 of about 374,748 (298)

Somatic Mutational Landscape of Splicing Factor Genes and Their Functional Consequences across 33 Cancer Types [PDF]

, 2018
Hotspot mutations in splicing factor genes have been recently reported at high frequency in hematological malignancies, suggesting the importance of RNA splicing in cancer.
Alvaro, Domenico, Anant A, Agrawal, Bragazzi, MARIA CONSIGLIA, Cardinale, Vincenzo, Gaudio, Eugenio, James, Palacino, Lihua, Yu, Michael, Seiler, Peter G, Smith, Ping, Zhu, Shouyong, Peng, Silvia, Buonamici, Teng, Teng   +12 more
core   +1 more source

RNA. Prescribing splicing.

Science (New York, N.Y.), 2015
Prescribing ...
Guigó Serra, Roderic, Valcárcel, J. (Juan)   +1 more
openaire   +3 more sources

PPP3CB overexpression mediates EGFR TKI resistance in lung tumors via calcineurin/MEK/ERK signaling

Life Science Alliance
A triple osimertinib/calcineurin A/trametinib combination of treatment overcomes acquired resistance to EGFR TKI in EGFR-mutant lung adenocarcinoma cells that overexpress PPP3CB.
Sylvie Gazzeri, Nadiia Zubchuk, Elodie Montaudon, Fariba Nemati, Sarah Huot-Marchand, Giulia Berardi, Amelie Pucciarelli, Yassir Dib, Dylan Nerini, Christiane Oddou, Mylène Pezet, Laurence David-Boudet, Camille Ardin, Florence de Fraipont, Antonio Maraver, Nicolas Girard, Didier Decaudin, Anne-Claire Toffart, Beatrice Eymin   +18 more
doaj   +1 more source

Spliced leader RNA trans-splicing discovered in copepods [PDF]

Scientific Reports, 2015
AbstractCopepods are one of the most abundant metazoans in the marine ecosystem, constituting a critical link in aquatic food webs and contributing significantly to the global carbon budget, yet molecular mechanisms of their gene expression are not well understood. Here we report the detection of spliced leader (SL) trans-splicing in calanoid copepods.
Feifei Yang, Donghui Xu, Yunyun Zhuang, Xiaoyan Yi, Yousong Huang, Hongju Chen, Senjie Lin, David A. Campbell, Nancy R. Sturm, Guangxing Liu, Huan Zhang   +10 more
openaire   +2 more sources

rMAPS: RNA map analysis and plotting server for alternative exon regulation. [PDF]

, 2016
RNA-binding proteins (RBPs) play a critical role in the regulation of alternative splicing (AS), a prevalent mechanism for generating transcriptomic and proteomic diversity in eukaryotic cells.
Jung, Sungbo, Park, Juw Won, Rouchka, Eric C, Tseng, Yu-Ting, Xing, Yi   +4 more
core   +2 more sources

Dysregulation of RNA Splicing in Tauopathies

Cell Reports, 2019
Summary: Pathological aggregation of RNA binding proteins (RBPs) is associated with dysregulation of RNA splicing in PS19 P301S tau transgenic mice and in Alzheimer’s disease brain tissues. The dysregulated splicing particularly affects genes involved in
Daniel J. Apicco, Cheng Zhang, Brandon Maziuk, Lulu Jiang, Heather I. Ballance, Samantha Boudeau, Choong Ung, Hu Li, Benjamin Wolozin   +8 more
doaj   +1 more source

The contribution of Alu exons to the human proteome. [PDF]

, 2016
BackgroundAlu elements are major contributors to lineage-specific new exons in primate and human genomes. Recent studies indicate that some Alu exons have high transcript inclusion levels or tissue-specific splicing profiles, and may play important ...
Jiang, Peng, Lam, Maggie PY, Lin, Lan, Lu, Zhi-Xiang, Park, Juw Won, Ping, Peipei, Wang, Jinkai, Xing, Yi   +7 more
core   +1 more source

Understanding splicing regulation through RNA splicing maps

Trends in Genetics, 2011
Alternative splicing is a highly regulated process that greatly increases the proteome diversity and plays an important role in cellular differentiation and disease. Interactions between RNA-binding proteins (RBPs) and pre-mRNA are the principle regulator of splicing decisions.
Witten, Joshua T., Ule, Jernej
openaire   +2 more sources

Incorporating evolutionary information and functional domains for identifying RNA splicing factors in humans. [PDF]

PLoS ONE, 2011
Regulation of pre-mRNA splicing is achieved through the interaction of RNA sequence elements and a variety of RNA-splicing related proteins (splicing factors).
Justin Bo-Kai Hsu, Neil Arvin Bretaña, Tzong-Yi Lee, Hsien-Da Huang   +3 more
doaj   +1 more source

Splicing of the U6 RNA precursor is impaired in fission yeast pre-mRNA splicing mutants [PDF]

, 1989
U6 RNA is a member of a class of small abundant stable nuclear RNAs that are essential for splicing. In all species examined so far, the U6 RNA is a RNA polymerase III transcript.
Potashkin, J., Frendewey, D.
core   +1 more source