Results 61 to 70 of about 4,719,315 (357)

ADAR2 regulates RNA stability by modifying access of decay-promoting RNA-binding proteins

Nucleic Acids Research, 2017
Adenosine deaminases acting on RNA (ADARs) catalyze the editing of adenosine residues to inosine (A-to-I) within RNA sequences, mostly in the introns and UTRs (un-translated regions). The significance of editing within non-coding regions of RNA is poorly
Aparna Anantharaman, Vidisha Tripathi, Abid A Khan, Je-Hyun Yoon, Deepak K. Singh, Omid Gholamalamdari, Shuomeng Guang, J. Ohlson, Helene Wahlstedt, Marie Öhman, M. Jantsch, N. Conrad, Jian Ma, M. Gorospe, S. Prasanth, K. Prasanth   +15 more
semanticscholar   +1 more source

Transcriptional Regulation of Gene Expression in \u3cem\u3eTetrahymena thermophila\u3c/em\u3e [PDF]

, 1990
The only well-characterized study of gene expression in Tetrahymena thermophila (1) demonstrates that the temperature dependent expression of the Ser H3 gene is regulated at the level of mRNA stability.
Gorovsky, Martin A., Karrer, Kathleen M., Stargell, Laurie A.   +2 more
core   +1 more source

Crowding Promotes the Switch from Hairpin to Pseudoknot Conformation in Human Telomerase RNA

, 2011
Formation of a pseudoknot in the conserved RNA core domain in the ribonucleoprotein human telomerase is required for function. In vitro experiments show that the pseudoknot (PK) is in equilibrium with an extended hairpin (HP) structure.
Antal M., Asakura S., Blasco M. A., Bloomfield V. A., Cao S., Cao S., Chen J. L., Cheung M. S., Comolli L. R., D. Thirumalai, Denesyuk N. A., Dhar A., Feng J., Gilley D., Hyeon C., Kilburn D., Kirkpatrick T. R., Leontis N. B., Lin J. C., McGuffee S. R., Montange R. K., Natalia A. Denesyuk, Pincus D. L., Shaw M. R., Theimer C. A., Theimer C. A., Thirumalai D., Walter H., Whitford P. C., Xia T., Zhou H.-X.   +30 more
core   +1 more source

Reciprocal regulation of A-to-I RNA editing and the vertebrate nervous system [PDF]

, 2013
The fine control of molecules mediating communication in the nervous system is key to adjusting neuronal signaling during development and in maintaining the stability of established networks in the face of altered sensory input.
Ales eBalik, Andrew Charles Penn, Andrew Charles Penn, Ingo H Greger   +3 more
core   +2 more sources

RNA stability protein ILF3 mediates cytokine‐induced angiogenesis

The FASEB Journal, 2018
Interleukin enhancer‐binding factor 3 (ILF3), an RNA‐binding protein, is best known for its role in innate immunity by participation in cellular antiviral responses. A role for ILF3 in angiogenesis is unreported.
Christine N. Vrakas, Allison B Herman, M. Ray, S. Kelemen, R. Scalia, M. Autieri   +5 more
semanticscholar   +1 more source

Kaposi's sarcoma-associated herpesvirus ORF57 protein binds and protects a nuclear noncoding RNA from cellular RNA decay pathways. [PDF]

PLoS Pathogens, 2010
The control of RNA stability is a key determinant in cellular gene expression. The stability of any transcript is modulated through the activity of cis- or trans-acting regulatory factors as well as cellular quality control systems that ensure the ...
Brooke B Sahin, Denish Patel, Nicholas K Conrad   +2 more
doaj   +1 more source

Neuronal Cells Display Distinct Stability Controls of Alternative Polyadenylation mRNA Isoforms, Long Non-Coding RNAs, and Mitochondrial RNAs

Frontiers in Genetics, 2022
RNA stability plays an important role in gene expression. Here, using 3′ end sequencing of newly made and pre-existing poly(A)+ RNAs, we compare transcript stability in multiple human cell lines, including HEK293T, HepG2, and SH-SY5Y.
Aysegul Guvenek, Aysegul Guvenek, Jihae Shin, Lidia De Filippis, Dinghai Zheng, Wei Wang, Zhiping P. Pang, Bin Tian, Bin Tian   +8 more
doaj   +1 more source

Interaction vesicles as emerging mediators of host‐pathogen molecular crosstalk and their implications for infection dynamics

FEBS Letters, EarlyView.
Interaction extracellular vesicles (iEVs) are hybrid vesicles formed through host‐pathogen communication. They facilitate immune evasion, transfer pathogens' molecules, increase host cell uptake, and enhance virulence. This Perspective article illustrates the multifunctional roles of iEVs and highlights their emerging relevance in infection dynamics ...
Bruna Sabatke, Izadora Volpato Rossi, Marcel I. Ramirez   +2 more
wiley   +1 more source

Role of the central cations in the mechanical unfolding of DNA and RNA G-quadruplexes. [PDF]

, 2015
Cations are known to mediate diverse interactions in nucleic acids duplexes but they are critical in the arrangement of four-stranded structures. Here, we use all-atom molecular dynamics simulations with explicit solvent to analyse the mechanical ...
Arias-Gonzalez, JR, Bergues-Pupo, AE, Falo, F, Fiasconaro, A, Morón, MC   +4 more
core   +6 more sources

Analysis of RNA decay factor mediated RNA stability contributions on RNA abundance

BMC Genomics, 2015
BackgroundHistone epigenome data determined by chromatin immunoprecipitation sequencing (ChIP-seq) is used in identifying transcript regions and estimating expression levels. However, this estimation does not always correlate with eventual RNA expression
Sho Maekawa, N. Imamachi, T. Irie, Hidenori Tani, Kyoko Matsumoto, R. Mizutani, K. Imamura, Miho Kakeda, T. Yada, S. Sugano, Yutaka Suzuki, N. Akimitsu   +11 more
semanticscholar   +1 more source