Results 111 to 120 of about 8,924,942 (310)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Differential stability of 2'F-ANA*RNA and ANA*RNA hybrid duplexes: roles of structure, pseudohydrogen bonding, hydration, ion uptake and flexibility

, 2010
14 pags., 7 figs., 3 tabs.Hybrids of RNA with arabinonucleic acids 2′F-ANA and ANA have very similar structures but strikingly different thermal stabilities.
Portella, Guillem, Orozco, Modesto, Schwartzentruber, Jeremy, Gonzalez, Carlos, Martín-Pintado, N., Damha, Masad J., Martin-Pintado, Nerea, Gomez-Pinto, Irene, Watts, Jonathan K., Watts, Johnathan K.   +9 more
core   +1 more source

A twist in the tail : SHAPE mapping of long-range interactions and structural rearrangements of RNA elements involved in HCV replication [PDF]

, 2011
The RNA structure and long-range interactions of the SL9266 cis-acting replication element located within the NS5B coding region of hepatitis C virus (HCV) were determined using selective 2′-hydroxyl acylation analysed by primer extension.
Tuplin, Andrew, Struthers, Madeleine, Struthers, M., Andrew Tuplin, Tuplin, A., Struthers, M, Madeleine Struthers, Simmonds, Peter, David J. Evans, Tuplin, A, Evans, DJ, Peter Simmonds, Evans, David J., Simmonds, P., Evans, D. J., Simmonds, P, Evans, David J.; id_orcid   +16 more
core   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

RNA-Puzzles: A CASP-like evaluation of RNA three-dimensional structure prediction.: [PDF]

, 2012
We report the results of a first, collective, blind experiment in RNA three-dimensional (3D) structure prediction, encompassing three prediction puzzles.
Rother, K., Rother, M., Philips, A., Ding, F., Waldsich, C., Patel, D. J., Das, R., Chen, S.-J., Lavender, C. A., Skorupski, M., Cao, S., Blanchet, M.-F., Cruz, J. A., Flores, S. C., Santalucia, J., Lisi, V., Wildauer, M., Dokholyan, N. V., Soltysinski, T., Hermann, T., Sripakdeevong, P., Serganov, A., Leontis, N. B., Boniecki, M., Weeks, K. M., Major, F., Tuszynska, I., Puton, T., Bujnicki, J. M., Huang, L., Mikolajczak, K., Sijenyi, F., Waldsich, C. (C), Westhof, E. (Eric), Mikolajczak, K, Rother, Magdalena, Mikolajczak, K. (K), Dokholyan, Nikolay V., Cruz, J. (J) A. (A), Soltysinski, T. (T), Boniecki, Michal, Cruz, J, Cao, S. (S), Ding, Feng, Dokholyan, N. (N) V. (V), Santalucia, John, Patel, Dinshaw J., Boniecki, M, Major, F. (F), Skorupski, Marcin, Rother, Kristian, Weeks, Kevin M., Philips, A. (A), Wildauer, Michael, Chen, Shi-Jie, Huang, Lili, Skorupski, M, Lavender, C. (C) A. (A), Major, F, Weeks, K. (K) M. (M), Lisi, V. (V), Dokholyan, N, Huang, L. (L), Leontis, N. (N) B. (B), Puton, T, Das, Rhiju, Hermann, T, Philips, A, Puton, T. (T), Philips, Anna, Santalucia, J. (J), Soltysinski, T, Das, R. (R), Bujnicki, J. (J) M. (M), Lavender, C, Leontis, N, Ding, F. (F), Lavender, Christopher A., Sijenyi, F, Serganov, A, Rother, K, Leontis, Neocles B., Lisi, Veronique, Rother, M, Blanchet, Marc-Frederick, Sripakdeevong, P, Sripakdeevong, P. (P), Waldsich, C, Cao, Song, Skorupski, M. (M), Bujnicki, J, Flores, S, Serganov, Alexander, Soltysinski, Tomasz, Tuszynska, Irina, Rother, K. (K), Puton, Tomasz, Das, R, Flores, S. (S) C. (C), Serganov, A. (A), Bujnicki, Janusz M., Lisi, V, Cruz, Jose Almeida, Coulbourn Flores, Samuel,, Chen, S, Blanchet, M. (M) F. (F), Major, Francois, Hermann, T. (T), Cao, S, Santalucia, J, Wildauer, M. (M), Weeks, K, Boniecki, M. (M), Rother, M. (M), Tuszynska, I, Waldsich, Christina, Tuszynska, I. (I), Sijenyi, Fredrick, Sripakdeevong, Parin, Ding, F, Blanchet, M, Chen, S. (S) J. (J), Patel, D, Westhof, Eric, Patel, D. (D) J. (J), Sijenyi, F. (F), Hermann, Thomas, Mikolajczak, Katarzyna, Huang, L, Wildauer, M, Patel, Dinshaw, Bujnicki, Janusz, Lavender, Christopher, Weeks, Kevin, Dokholyan, Nikolay, Flores, Samuel Coulbourn, Leontis, Neocles   +136 more
core   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

An essential role of KREPB4 in RNA editing and structural integrity of the editosome in Trypanosoma brucei [PDF]

, 2007
RNA editing in the sleeping sickness parasite Trypanosoma brucei remodels mitochondrial transcripts by the addition and deletion of uridylates as specified by guide RNAs.
Schnaufer, Achim; id_orcid, Stuart, Kenneth, Ernst, Nancy Lewis, Fleck, Michele, Babbarwal, Vinod Kumar   +4 more
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

On the significance of an RNA tertiary structure prediction [PDF]

, 2010
Tertiary structure prediction is important for understanding structure–function relationships for RNAs whose structures are unknown and for characterizing RNA states recalcitrant to direct analysis. However, it is unknown what root-mean-square deviation (
F. Ding, N. V. Dokholyan, Hajdin, C. E., Weeks, K. M., C. E. Hajdin, K. M. Weeks, Dokholyan, N. V., Ding, F.   +7 more
core   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source