Results 91 to 100 of about 8,924,942 (310)

L11 domain rearrangement upon binding to RNA and thiostrepton studied by NMR spectroscopy [PDF]

, 2006
Ribosomal proteins are assumed to stabilize specific RNA structures and promote compact folding of the large rRNA. The conformational dynamics of the protein between the bound and unbound state play an important role in the binding process.
Wöhnert, Jens, Hendrik R. A. Jonker, Harald Schwalbe, Ilin, Serge, S. Kaspar Grimm, Grimm, Steffen Kaspar, Jens Wöhnert, Jonker, Hendrik R. A., Schwalbe, Harald (Prof. Dr.), Serge Ilin   +9 more
core   +2 more sources

Structure of Eukaryotic RNA Polymerases

Annual Review of Biophysics, 2008
The eukaryotic RNA polymerases Pol I, Pol II, and Pol III are the central multiprotein machines that synthesize ribosomal, messenger, and transfer RNA, respectively. Here we provide a catalog of available structural information for these three enzymes. Most structural data have been accumulated for Pol II and its functional complexes.
Cramer, P., Armache, K.-J., Baumli, S., Benkert, S., Brueckner, F., Buchen, C., Damsma, G.E., Dengl, S., Geiger, S.R., Jasiak, A.J., Jawhari, A., Jennebach, S., Kamenski, T., Kettenberger, H., Kuhn, C.-D., Lehmann, E., Leike, K., Sydow, J.F., Vannini, A.   +18 more
openaire   +5 more sources

Structure of the Escherichia coli ProQ RNA-binding protein [PDF]

, 2017
The protein ProQ has recently been identified as a global small noncoding RNA-binding protein in Salmonella, and a similar role is anticipated for its numerous homologs in divergent bacterial species.
Broadhurst, R. William, Holmqvist, Erik,, Gonzalez, Grecia M.,, Vogel, Jörg, Bateman, Alex,, Ben F. Luisi, Steven W. Hardwick, R. William Broadhurst, Luisi, Ben F.,, Maslen, Sarah L, Gonzalez, Grecia M., Hardwick, Steven W.,, Vogel, Jörg,, Sarah L. Maslen, J. Mark Skehel, Alex Bateman, Skehel, J Mark, Broadhurst, R William, Hardwick, Steven W., Erik Holmqvist, Holmqvist, Erik, Luisi, Ben F, Maslen, Sarah L., Jörg Vogel, Broadhurst, R. William,, Luisi, Ben F., Grecia M. Gonzalez, Skehel, J. Mark,, Bateman, Alex, Maslen, Sarah L.,, Hardwick, Steven W, Gonzalez, Grecia M, Skehel, J. Mark   +32 more
core   +1 more source

A novel cGUUAg tetraloop structure with a conserved yYNMGg-type backbone conformation from cloverleaf 1 of bovine enterovirus 1 RNA [PDF]

, 2006
The 5'-terminal cloverleaf (CL)-like RNA structures are essential for the initiation of positive- and negative-strand RNA synthesis of entero- and rhinoviruses.
Görlach, Matthias, Zacharias, Martin, Häfner, Sabine, Ramachandran, Ramadurai, Ihle, Yvonne, Ohlenschläger, Oliver, Zell, Roland, Seitz, Simone, Duchardt-Ferner, Elke   +8 more
core   +1 more source

RNA tertiary structure modeling with BRiQ potential in CASP15

, 2023
We describe the modeling method for RNA tertiary structures employed by team AIchemy_RNA2 in the 15th Critical Assessment of Structure Prediction (CASP15). The method consists of the following steps.
Chen, K, Yaoqi Zhou, Xiong, P, Sheng Wang, Ke Chen, Zhou, Y, Wang, S, Peng Xiong   +7 more
core   +1 more source

A hepatitis C virus cis-acting replication element forms a long-range RNA-RNA interaction with upstream RNA sequences in NS5B [PDF]

, 2008
The genome of hepatitis C virus (HCV) contains cis-acting replication elements (CREs) comprised of RNA stem-loop structures located in both the 5' and 3' non-coding regions (NCR), and in the NS5B coding sequence.
Diviney, Sinéad, Elliot, R., Evans, David John, Evans, D., Armstrong, V, Tuplin, Andrew, Evans, D.J., Struthers, Madeleine, Struthers, M., Elliott, Richard M., Diviney, S., Tuplin, A., Armstrong, V., Struthers, M, Simmonds, Peter, Elliott, Richard Michael, Armstrong, Victoria, Tuplin, A, Evans, David J., Simmonds, P., Diviney, S, Elliott, R.M., Simmonds, P, Evans, David John; id_orcid   +23 more
core   +1 more source

Comparing the paths of Hedgehog release in artificial and natural settings

FEBS Letters, EarlyView.
Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley   +1 more source

DIS3 mutations enhance AID-driven translocations during B-cell activation, promoting transformation to multiple myeloma

Nature Communications
DIS3, a key nuclear RNA-degrading enzyme, is essential for immunoglobulin class switch recombination (CSR), promoting activation-induced cytidine deaminase (AID) activity on both DNA strands to induce double-strand DNA breaks.
Tomasz M. Kuliński, Olga Gewartowska, Mélanie Mahé, Karolina Kasztelan, Nina Durys, Anna Stroynowska-Czerwińska, Marta Jedynak-Slyvka, Ewelina P. Owczarek, Debadeep Chaudhury, Marcin Nowotny, Aleksandra Pękowska, Bertrand Séraphin, Andrzej Dziembowski   +12 more
doaj   +1 more source

RNA Regulations and Functions Decoded by Transcriptome-wide RNA Structure Probing

Genomics, Proteomics & Bioinformatics, 2017
RNA folds into intricate structures that are crucial for its functions and regulations. To date, a multitude of approaches for probing structures of the whole transcriptome, i.e., RNA structuromes, have been developed. Applications of these approaches to
Meiling Piao, Lei Sun, Qiangfeng Cliff Zhang   +2 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source