Results 91 to 100 of about 1,628,380 (301)
Fatgraph models of RNA structure
Computational and Mathematical Biophysics, 2017 In this review paper we discuss fatgraphs as a conceptual framework for RNA structures. We discuss various notions of coarse-grained RNA structures and relate them to fatgraphs.We motivate and discuss the main intuition behind the fatgraph model and ...
Huang Fenix +2 more
doaj +1 more source
RNA Dependent RNA Polymerases: Insights from Structure, Function and Evolution
Viruses, 2018 RNA dependent RNA polymerase (RdRp) is one of the most versatile enzymes of RNA viruses that is indispensable for replicating the genome as well as for carrying out transcription.
Sangita Venkataraman +2 more
doaj +1 more source
The helicase Ded1p controls use of near-cognate translation initiation codons in 5' UTRs. [PDF]
, 2018 The conserved and essential DEAD-box RNA helicase Ded1p from yeast and its mammalian orthologue DDX3 are critical for the initiation of translation1.
Bartel, David P +10 more
core +1 more source
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
RNA Regulations and Functions Decoded by Transcriptome-wide RNA Structure Probing
Genomics, Proteomics & Bioinformatics, 2017 RNA folds into intricate structures that are crucial for its functions and regulations. To date, a multitude of approaches for probing structures of the whole transcriptome, i.e., RNA structuromes, have been developed. Applications of these approaches to
Meiling Piao +2 more
doaj +1 more source
Statistical modeling of RNA structure profiling experiments enables parsimonious reconstruction of structure landscapes. [PDF]
, 2018 RNA plays key regulatory roles in diverse cellular processes, where its functionality often derives from folding into and converting between structures.
Aviran, Sharon, Li, Hua
core +2 more sources
Clustering RNA structural motifs in ribosomal RNAs using secondary structural alignment [PDF]
Nucleic Acids Research, 2011 RNA structural motifs are the building blocks of the complex RNA architecture. Identification of non-coding RNA structural motifs is a critical step towards understanding of their structures and functionalities. In this article, we present a clustering approach for de novo RNA structural motif identification.
Zhong, Cuncong, Zhang, Shaojie
openaire +3 more sources
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
, 1995 We view the folding of RNA-sequences as a map that assigns a pattern of base pairings to each sequence, known as secondary structure. These preimages can be constructed as random graphs (i.e. the neutral networks associated to the structure $s$).
Christian Reidys +3 more
core +3 more sources
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source