Results 101 to 110 of about 9,541,112 (326)

The impact of leukocyte‐associated RNA retention on platelet RNA‐based cancer detection

Molecular Oncology, EarlyView.
Platelets carry RNA signals that may help detect cancer, but platelet samples can also retain RNA from white blood cells. We found that this retained white blood cell signal did not significantly affect machine learning cancer classification, suggesting that the cancer‐related RNA signal in platelets is largely independent of leukocyte‐associated RNA ...
Michał Sieczczyński, Krzysztof Pastuszak, Anna Samelak‐Czajka, Zuzanna Cemka, Paulina Jackowiak, Tomasz Stefaniak, Sylwia Łapińska‐Szumczyk, Jacek Jassem, Anna J. Żaczek, Matthew T. Rondina, Myron G. Best, Sjors G. J. G. In 't Veld, Anna Supernat   +12 more
wiley   +1 more source

RNANetMotif: Identifying sequence-structure RNA network motifs in RNA-protein binding sites.

PLoS Computational Biology, 2022
RNA molecules can adopt stable secondary and tertiary structures, which are essential in mediating physical interactions with other partners such as RNA binding proteins (RBPs) and in carrying out their cellular functions.
Hongli Ma, Han Wen, Zhiyuan Xue, Guojun Li, Zhaolei Zhang   +4 more
doaj   +1 more source

RNA Tertiary Structure Analysis by 2′-Hydroxyl Molecular Interference

, 2016
: We introduce a melded chemical and computational approach for probing and modeling higher-order intramolecular tertiary interactions in RNA. 2′-Hydroxyl molecular interference (HMX) identifies nucleotides in highly packed regions of an RNA by ...
Greggory M. Rice, Philip J. Homan, Arpit T, Feng Ding, Arpit Tandon (476362), Nikolay V. Dokholyan (84409), Kevin M. Weeks (367405), Kevin M. Weeks, Greggory M. Rice (1727200), Nikolay V. Dokholyan, Philip J. Homan (1727203), Feng Ding (33360)   +11 more
core   +1 more source

A novel cGUUAg tetraloop structure with a conserved yYNMGg-type backbone conformation from cloverleaf 1 of bovine enterovirus 1 RNA [PDF]

, 2006
The 5'-terminal cloverleaf (CL)-like RNA structures are essential for the initiation of positive- and negative-strand RNA synthesis of entero- and rhinoviruses.
Görlach, Matthias, Zacharias, Martin, Häfner, Sabine, Ramachandran, Ramadurai, Ihle, Yvonne, Ohlenschläger, Oliver, Zell, Roland, Seitz, Simone, Duchardt-Ferner, Elke   +8 more
core   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Predicting small molecule–RNA interactions without RNA tertiary structures

Nature Biotechnology
Small molecules can bind RNAs to regulate their fate and functions, providing promising opportunities for treating human diseases. However, current tools for predicting small molecule-RNA interactions (SRIs) require prior knowledge of RNA tertiary structures.
Yuhan Fei, Pengfei Wang, Jiasheng Zhang, Xinyue Shan, Zilin Cai, Jianbo Ma, Yangming Wang, Qiangfeng Cliff Zhang   +7 more
openaire   +2 more sources

KDAC6 alters cell morphology and motility through positive and negative modulation of F‐actin distribution

FEBS Open Bio, EarlyView.
KDAC6 has been associated with cell motility and actin structures, but specific domain contributions are not established. The two catalytic domains have differential effects on motility and F‐actin regulation, affecting cortical F‐actin density, motility, stress fibers, and cell spreading.
Taylor V. Joseph, Andrea B. Pham, Kiara E. Bornes, Razan H. Hammad, Chelsea A. Rousseve‐Ross, Thomas M. Huckaba, Terry J. Watt, Tasha B. Toro   +7 more
wiley   +1 more source

Structure of the Complete RNA Polymerase II Elongation Complex and its Interaction with the Elongation Factor TFIIS [PDF]

, 2005
This thesis describes crystal structures of complete, 12-subunit yeast RNA polymerase II (Pol II) in complex with a synthetic transcription bubble and product RNA, with an NTP substrate analogue, and in complex with the transcription elongation factor ...
Kettenberger, Hubert
core   +1 more source

Recognizing RNA structural motifs in HT-SELEX data for ribosomal protein S15

BMC Bioinformatics, 2017
Background Proteins recognize many different aspects of RNA ranging from single stranded regions to discrete secondary or tertiary structures. High-throughput sequencing (HTS) of in vitro selected populations offers a large scale method to study RNA ...
Shermin Pei, Betty L. Slinger, Michelle M. Meyer   +2 more
doaj   +1 more source

Algorithms for RNA secondary structure analysis : prediction of pseudoknots and the consensus shapes approach [PDF]

, 2007
Reeder J. Algorithms for RNA secondary structure analysis : prediction of pseudoknots and the consensus shapes approach. Bielefeld (Germany): Bielefeld University; 2007.Our understanding of the role of RNA has undergone a major change in the last decade.
Reeder, Jens
core