Results 161 to 170 of about 9,541,112 (326)

GaSex Nanoparticles Modulate Neutrophil Function and Mitigate NET‐Driven Osteogenic Impairment in Osteomyelitis Therapy

Advanced Materials, EarlyView.
Neutrophil extracellular traps (NETs) emerge as a critical repair‐limiting factor in osteomyelitis, driving osteoblast mitochondrial dysfunction and excessive PINK1/Parkin‐mediated mitophagy. Gallium–selenium nanoparticles (GaSex) scavenge reactive oxygen species, redirect neutrophils from NETosis toward bactericidal phagocytosis, eliminate methicillin‐
Kai Ye, Xuanzhe Liu, Zifan Pei, Chenyi Jiang, Xiaofen Zhang, Lin Lin, Qihang Fang, Binyu Chen, Longxiang Shen, Liang Cheng, Peng Ding, Xianyou Zheng   +11 more
wiley   +1 more source

pH‐Responsive Synthetic Cells for Programmable In Situ Protein Synthesis and Release

Advanced Materials, EarlyView.
A synthetic cell is engineered to convert environmental acidification into nucleic acid signaling that activates protein synthesis. By coupling proton‐channel sensing, pH‐responsive DNA transduction, and toehold‐regulated translation, the platform enables acid‐triggered protein production within hydrogel‐embedded synthetic cells.
Sung‐Won Hwang, Yudan Li, Alexander A. Green, Allen P. Liu   +3 more
wiley   +1 more source

A path to predict RNA tertiary structures [PDF]

Nature Methods, 2018
openaire   +2 more sources

Reduced Graphene Oxide Enhances the Vascular Organization and Contractile Performance of Fibrin‐Gelatin‐Based Engineered Cardiac Tissue

Advanced Materials Interfaces, EarlyView.
Fibrin–gelatin hydrogels functionalized with reduced graphene oxide create a mechanically stable and bioactive 3D environment for engineered cardiac tissue. The composite matrix promotes endothelial lumen formation, enhances sarcomeric protein expression, and increases contractile performance of embedded cardiomyocytes.
Christoph Kuckelkorn, Marie Baiker, Yajuan Jiang, Ebru Aksoy, Kurt Pfannkuche, Horst Fischer   +5 more
wiley   +1 more source

Microfluidic Droplet Plate Preserving Single Human Induced Pluripotent Stem Cell‐Derived Cardiomyocytes Morphology and Function

Advanced Materials Technologies, EarlyView.
We introduce a novel method combining microfluidics, optogenetics, and human induced pluripotent stem cell (iPSC) technology to encapsulate single iPSC‐derived cardiomyocytes (iPSC‐CMs) in an optimal environment for functional characterization. This method enables direct genotype‐phenotype correlation for genetic studies and high‐throughput screening ...
Xiao‐Ting Wang, Rachel P. White, Yashasvi Tharani, Michael A. Finocchiaro, Leona M. Ripple, Maksymilian Prondzynski, Tania Konry, Vassilios J. Bezzerides   +7 more
wiley   +1 more source

An Anti‐Amyloidogenic Approach to Specifically Block Memory Consolidation in Mice for Therapeutic Intervention

Advanced Science, EarlyView.
Functional amyloid conversion of the translation regulator CPEB3 is essential for long‐term memory persistence. This study demonstrates that targeting this molecular switch with the anti‐amyloidogenic peptide QBP1 selectively blocks CPEB3 fibrillation without disrupting phase separation.
Paula López‐García, Kerry R. McGreevy, Maria Eugenia Vaquero, Juan M. Suarez‐Rivero, Antonio Moreno‐Rodríguez, Antonio J. Pérez‐Pulido, Daniel Ramírez de Mingo, Anna Pallé, Helena Akiko Popiel, Andrea Santi, Mario D. Cordero, José Luis Trejo, Yoshitaka Nagai, Mariano Carrión‐Vázquez   +13 more
wiley   +1 more source

Genome-scale characterization of RNA tertiary structures and their functional impact by RNA solvent accessibility prediction

, 2016
As most RNA structures are elusive to structure determination, obtaining solvent accessible surface areas (ASAs) of nucleotides in an RNA structure is an important first step to characterize potential functional sites and core structural regions.
Wang, Jihua, Zhan, Jian, Zhou, Yaoqi, Yaoqi Zhou, Li, Xiaomei, Yuedong Yang, Jian Zhan, Huiying Zhao, Yang, Yuedong, Zhao, Huiying, Xiaomei Li, Jihua Wang   +11 more
core   +1 more source

Rab1A Promotes Hepatic Steatosis by Suppressing Mitophagy via the Raf‐1/ERK1/2/PINK1 Signaling Axis

Advanced Science, EarlyView.
Why does fat accumulate in the liver? Our study reveals Rab1A as the molecular switch that silences the cell's mitochondrial cleanup crew. Turning Rab1A off reactivates mitophagy, clears excess fat, and reverses fatty liver disease in mice—offering a promising new therapeutic target for MASLD, a growing global health challenge.
Li Zhang, Jianhua Li, Huilu Zhang, Qi Qin, Yichen Huang, Xiaofan Tian, Chao Sun, Binbin Li, Zhengxin Wang, Xin Zhang   +9 more
wiley   +1 more source

PRIME-BSPre: a genome-wide protein-RNA binding sites prediction method based on templates

BMC Genomics
In this paper, we present PRIME-BSPre, a template-based genome-wide method for predicting protein-RNA binding sites that incorporates the RNA sequence and secondary structure as well as the tertiary structure of corresponding RBPs.
Xinhang Wei, Yingtian Duan, Danyang Li, Xudong Liu, Juan Xie, Shiyong Liu   +5 more
doaj   +1 more source

Template-based RNA tertiary structure prediction

, 2016
The thesis deals with proposal, implementation and testing of a new algorithm for homologous tertiary RNA structure prediction, which means using a structure similar to the template.
Galvánek, Rastislav
core