Results 201 to 210 of about 243,477 (250)

The Impact of COVID-19 on RNA Therapeutics: A Surge in Lipid Nanoparticles and Alternative Delivery Systems. [PDF]

Pharmaceutics
Parvin N, Mandal TK, Joo SW.
europepmc   +1 more source

Tissue‐Stimulator Platform for Electrically Stimulating Pancreatic β‐Cells for Long‐Term Functional Regulation

Advanced Functional Materials, EarlyView.
We present a tissue‐stimulator platform for seamless electrode integration with pancreatic tissue, applying uniform electrical stimulation through optimized design with biohybrid 3D printing. Advantageous effects of electrical stimulation on β‐cell function were observed, including enhanced calcium signaling, islet morphology, and maturation.
Jihwan Kim, Uijung Yong, Myungji Kim, Jaewook Kim, Yeonggwon Jo, In Kyong Shim, Song Cheol Kim, Jinah Jang   +7 more
wiley   +1 more source

In Silico Design of Novel EpCAM-Binding Aptamers for Targeted Delivery of RNA Therapeutics. [PDF]

Nanomaterials (Basel)
Driscoll J, Gondaliya P, Ziemer A, Yan IK, Gupta Y, Patel T.   +5 more
europepmc   +1 more source

Exploring an Alternative to mRNA Vaccine Cold Chain Storage: MRNA‐Lipid Nanoparticle Stability When Dried in a Polymer Matrix

Advanced Functional Materials, EarlyView.
The nanostructure, size, and function of mRNA‐loaded lipid nanoparticles are evaluated before drying, within polymer microneedles, and after rehydration. The results reveal the polymer and LNP loadings required to recover nanostructure and preserve the delivery performance in dry‐state formulations.
Brendan P. Dyett, Shahad K. Alsaiari, John L. Daristotle, Timothy A. Forster, Alicia Lau, Dhruv Varshney, Rania Afaneh, Andrew R. Hanna, Charles Sloane, David Mankus, Haitao Yu, Jiali Zhai, DongSoo Yun, Lisa H. Tostanoski, Abigail Lytton‐Jean, Dan H. Barouch, Charlotte E. Conn, Robert Langer, Ana Jaklenec, Calum J. Drummond   +19 more
wiley   +1 more source

Developing an enhanced chimeric permuted intron-exon system for circular RNA therapeutics. [PDF]

Theranostics
Wang L, Dong C, Zhang W, Ma X, Rou W, Yang K, Cui T, Qi S, Yang L, Xie J, Yu G, Wang L, Chen X, Liu Z.   +13 more
europepmc   +1 more source

Pull‐and‐Push Nanotherapeutic Hydrogels: Scavenging Inflammatory Triggers While Driving Tissue Regeneration in Burn Wounds

Advanced Functional Materials, EarlyView.
A nanounit‐assembled hydrogel employing a “pull‐and‐push” strategy simultaneously scavenges pro‐inflammatory cell‐free DNA (cfDNA) and delivers regenerative therapeutics in response to burn‐induced hyperthermia. By repolarizing macrophages and promoting angiogenesis, this multifunctional platform accelerates burn wound healing, offering a blueprint for
Han‐Sem Kim, Seong‐Jin Shin, Sak Lee, Nandin Mandakhbayar, Ji‐Hye Kang, Da‐Young Kong, Seong‐Doo Hong, Ueon Sang Shin, Hae‐Won Kim, Jung‐Hwan Lee   +9 more
wiley   +1 more source

Neurological efficacy and safety of RNA therapeutics in hereditary transthyretin amyloidosis: a systematic review and meta-analysis of randomized controlled trials. [PDF]

Ther Adv Cardiovasc Dis
Sajjad M, Ashraf R, Bhagwan R, Ijaz H, Ejaz A, Qadeer Ud Din H, Hussain A, Khan MM, Naeem U, Ali A.   +9 more
europepmc   +1 more source

Modular supramolecular polycations enable efficient delivery of RNA therapeutics and vaccines

Kopiasz R, Sallah H, Cavanagh R, Jones S, Moloney C, Shaughnessy LO, McCrorie P, Salem A, Bayraktutan H, Granger L, Hallac F, Ritchie A, Parmar S, Grabowska A, Patel P, Madhusudan S, Rahman R, McIntyre A, Shattock R, Makatsoris H, Coulston R, Howe A, Gurnani P, Stolnik S, Tregoning J, Alexander C.   +25 more
europepmc   +1 more source

Nucleic Acid Armor: Fortifying RNA Therapeutics through Delivery and Targeting Innovations for Immunotherapy. [PDF]

Int J Mol Sci
Jiang Y, Jiang B, Wang Z, Li Y, Cheung JCW, Yin B, Wong SHD.   +6 more
europepmc   +1 more source

Navigating the intricate in-vivo journey of lipid nanoparticles tailored for the targeted delivery of RNA therapeutics: a quality-by-design approach. [PDF]

J Nanobiotechnology
Haghighi E, Abolmaali SS, Dehshahri A, Mousavi Shaegh SA, Azarpira N, Tamaddon AM.   +5 more
europepmc   +1 more source