Results 211 to 220 of about 243,477 (250)

Circular RNA: An emerging frontier in RNA therapeutic targets, RNA therapeutics, and mRNA vaccines

Journal of Controlled Release, 2022
Circular RNAs (circRNA) is a class of natural (biogenic) or synthetic closed RNA without 5' or 3' ends. Meanwhile, their unique covalently-closed structures of circRNA prevent RNA degradation by exonucleases, thereby empowering them with high pharmaceutical stability and biostability relative to current standard-of-care linear mRNA. Natural circRNA can
Shurong Zhou, Lei Mei, Guizhi Zhu
exaly   +3 more sources

RNA therapeutics for retinal diseases

Expert Opinion on Biological Therapy, 2020
In the retina, noncoding RNA (ncRNA) plays an integral role in regulating apoptosis, inflammatory responses, visual perception, and photo-transduction, with altered levels reported in diseased states.MicroRNA (miRNA), a class of ncRNA, regulates post-transcription gene expression through the binding of complementary sites of target messenger RNA (mRNA)
Michael C Gemayel, Ashay D. Bhatwadekar, Thomas Ciulla   +2 more
openaire   +2 more sources

Therapeutic applications of noncoding RNAs

Current Opinion in Cardiology, 2015
In this review, we summarize the basic principles underlying the therapeutic use of nonprotein coding (nc)RNAs, such as microRNA (miRNA) and long noncoding RNA, in the cardiovascular field, focusing, where possible, on recent advances that may lead to translation to the clinic for heart failure.The number of individual miRNAs associated with a given ...
M. V. G. Latronico, G. Condorelli
openaire   +3 more sources

RNA therapeutics for diarrhea

Diarrhea is caused by a variety of bacterial and viral agents, inflammatory conditions, medications, and hereditary conditions. Secretory diarrhea involves several ion and solute transporters, activation of the cyclic nucleotide and Ca2+ signaling pathways, as well as intestinal epithelial secretion.
Duy Ha, Nguyen, Md Jamal, Uddin, Jaffar A, Al-Tawfiq, Ziad A, Memish, Dinh-Toi, Chu   +4 more
openaire   +2 more sources

Types of RNA therapeutics

RNA therapy is one of the new treatments using small RNA molecules to target and regulate gene expression. It involves the application of synthetic or modified RNA molecules to inhibit the expression of disease-causing genes specifically. In other words, it silences genes and suppresses the transcription process.
Pouya, Goleij, Mehregan, Babamohamadi, Aryan, Rezaee, Pantea Majma, Sanaye, Mohammad Amin Khazeei, Tabari, Sarvin, Sadreddini, Reza, Arefnezhad, Hossein, Motedayyen   +7 more
openaire   +2 more sources

Therapeutic RNA and DNA enzymes

Biochemical Pharmacology, 2000
Recent progress in understanding how gene products interact in the control of cell proliferation has engendered high hopes for the rational design of specific therapeutic strategies. The demonstration that certain RNA and DNA nucleic acids can enzymatically cleave mRNAs has offered the possibility of inactivating abnormal gene expression. In principle,
M, Sioud, M, Leirdal
openaire   +2 more sources

Synthetic RNA Therapeutics in Cancer

The Journal of Pharmacology and Experimental Therapeutics, 2023
Recent advances in the RNA delivery system have facilitated the development of a separate field of RNA therapeutics, with modalities including mRNA, microRNA (miRNA), antisense oligonucleotide (ASO), small interfering RNA, and circular (circRNA) that have been incorporated into oncology research. The main advantages of the RNA-based modalities are high
Youngjin, Han, Seung-Hyun, Shin, Chang Gyu, Lim, Yong Ho, Heo, In Young, Choi, Ha Hyung, Kim   +5 more
openaire   +2 more sources

RNA therapeutics for heart disease

Biochemical Pharmacology, 2018
The majority of the human genome encodes non-coding RNAs (ncRNAs), species of RNA without protein-coding potential but with powerful regulatory functions in disease onset and progression. Functional studies demonstrate that both coding and ncRNAs underlie various mechanisms in heart disease and that molecules targeting RNA species show promising ...
De Majo, Federica, De Windt, Leon J.
openaire   +3 more sources

Ribozymes: RNA as a Therapeutic Agent

American Pharmacy, 1995
RZs, like ASO agents, are several years from approval by the Food and Drug Administration. Although many problems must be solved before they can be used effectively as therapeutic agents, results from a wide variety of in vitro and in vivo experiments are encouraging.
openaire   +2 more sources

Destroying RNA as a Therapeutic Approach

Current Medicinal Chemistry, 2006
The ability to target RNA, mRNA and viral RNA in particular, for degradation is a powerful approach in molecular biology and pharmacology. Such approaches can be used in the study of gene function as in functional genomics, in the identification of disease-associated genes, and for the treatment of human diseases.
Alaeddin, Tafech, Tyler, Bassett, Dan, Sparanese, Chow H, Lee   +3 more
openaire   +2 more sources