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RNA therapeutics for infectious diseases
Ribonucleic acids (RNAs), including the messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA), play important roles in living organisms and viruses. In recent years, the RNA-based technologies including the RNAs inhibiting other RNA activities, the RNAs targeting proteins, the RNAs reprograming genetic information, and the RNAs encoding ...Le Minh Tu, Phan +2 more
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RNA therapeutics for respiratory diseases
It has become increasingly common to utilize RNA treatment to treat respiratory illnesses. Experimental research on both people and animals has advanced quickly since the turn of the twenty-first century in an effort to discover a treatment for respiratory ailments that could not be accomplished with earlier techniques, specifically in treating ...Hue, Vu Thi +3 more
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RNA therapeutics in cancer treatment
RNA therapeutics are a class of drugs that use RNA molecules to treat diseases, including cancer. RNA therapeutics work by targeting specific genes or proteins involved in the disease process, with the aim of blocking or altering their activity to ultimately halt or reverse the disease progression.Minh Nam, Nguyen, Van Thai, Than
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An introduction to RNA therapeutics and their potentials
RNA therapeutics is a biological term regarding the usage of RNA-based molecules for medical purposes. Thanks to the success of mRNA-vaccine production against COVID-19, RNA therapeutics has gained more and more attention and investigation from worldwide scientists. It is considered as one of the promising alternatives for conventional drugs.Nhat-Le, Bui, Dinh-Toi, Chu
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The therapeutic potential of circular RNAs
Nature Reviews GeneticsOver the past decade, research into circular RNA (circRNA) has increased rapidly, and over the past few years, circRNA has emerged as a promising therapeutic platform. The regulatory functions of circRNAs, including their roles in templating protein translation and regulating protein and RNA functions, as well as their unique characteristics, such as ...
Eoghan O’Leary +4 more
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Therapeutic Potential of RNA Interference
New England Journal of Medicine, 2004RNA interference (RNAi) involves the use of easily generated RNA fragments to down-regulate gene expression in a highly specific manner. Since its discovery, about seven years ago, the method has quickly evolved and is now a routine application in many molecular laboratories.
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RNA therapeutics for β-thalassemia
β-thalassemia is an autosomal recessive disease, caused by one or more mutations in the β-globin gene that reduces or abolishes β-globin chain synthesis causing an imbalance in the ratio of α- and β-globin chain. Therefore, the ability to target mutations will provide a good result in the treatment of β-thalassemia.Hong-Quan, Duong +4 more
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RNA therapeutics for treatment of diabetes
Diabetes is an ongoing global problem as it affects health of more than 537 million people around the world. Diabetes leaves many serious complications that affect patients and can cause death if not detected and treated promptly. Some of the complications of diabetes include impaired vascular system, increased risk of stroke, neurological diseases ...Yen Vy, Nguyen Thi +4 more
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The Limitless Future of RNA Therapeutics
Frontiers in Bioengineering and Biotechnology, 2021Tulsi Ram Damase +2 more
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