Lymphoid and CXCR4 Cell Targeted Lipid Nanoparticles Facilitate HIV‐1 Proviral DNA Excision
Advancements in ART improve HIV‐1 patient outcomes but are unable to eliminate latent viral DNA. To address this, CXCR4‐targeted lipid nanoparticles (T‐LNPs) for delivering CRISPR‐Cas9 to excise HIV‐1 DNA in infected cells are developed. These T‐LNPs achieve ≈60% HIV‐1 DNA excision efficacy in blood and splenic tissue, demonstrating promise for ...
Sudipta Panja+6 more
wiley +1 more source
IS THE METAGON AN m-RNA IN PARAMECIUM AND A VIRUS IN DIDINIUM?
Ian Gıbson, T. M. Sonneborn
openalex +1 more source
Extracellular vesicles (EVs) are pivotal mediators of intercellular communication and disease, yet the fundamental mechanisms controlling their biogenesis and cargo selection remain unclear. This limitation hinders their diagnostic utility and therapeutic development.
Luís Carvalho Ferraz+2 more
wiley +1 more source
An Update on RNA Virus Discovery: Current Challenges and Future Perspectives. [PDF]
Debat H, Bejerman N.
europepmc +1 more source
Reverse transcription of turnip yellow mosaic virus RNA primed with calf-thymus DNA hydrolysate: characterization of the purified cDNA product [PDF]
J. Kummert, R. Kettmann
openalex +1 more source
A mechanically active OsteoChondral Unit (OCU)‐on‐Chip platform mimicking the OCU's functional anatomy and the strain gradient across the osteochondral interface is presented. Upon compartment‐specific hyperphysiological compression, the model replicates mechanisms observed in osteoarthritis (OA) progression, such as calcium crystal accumulation ...
Andrea Mainardi+10 more
wiley +1 more source
Anti-RNA virus crRNA targets efficient screening platform based on bioinformatics and CRISPR detection. [PDF]
Niu M+9 more
europepmc +1 more source
RNA nucleotide sequence clusters of normal and roussarcoma virus-infected tissues
Nicholas Delihas
openalex +1 more source
RNA-Dependent DNA Polymerase Activity in Five RNA Viruses: Divalent Cation Requirements [PDF]
E M Scolnick+3 more
openalex +1 more source
TRIM29 Negatively Regulates the Type I IFN Production in Response to RNA Virus
Junji Xing+4 more
semanticscholar +1 more source