Results 191 to 200 of about 614,534 (322)

Bilirubin Targeting WNK1 to Alleviate NLRP3‐Mediated Neuroinflammation

Advanced Science, EarlyView.
At physiological concentrations, bilirubin binds to the kinase domain of WNK1, thereby augmenting its activity and facilitating the phosphorylation of downstream SPAK/OSR1. This phosphorylation inhibits KCC2 activity, leading to elevate intracellular chloride levels in neurons.
Linfei Mao, Jiayu Lu, Quanjun Yang, Zhenqi Liu, Cuiping Wu, Bingbing Ke, Kaiyan Su, Haolin Yuan, Yaqi Cui, Yao Wang, Richard Salvi, Guang Yang, Shankai Yin, Feng Liu, Chunyan Li   +14 more
wiley   +1 more source

Two Birds With One Stone: RNA Virus Strategies to Manipulate G3BP1 and Other Stress Granule Components. [PDF]

Wiley Interdiscip Rev RNA
Firdaus MER, Dukhno E, Kapoor R, Gerlach P.   +3 more
europepmc   +1 more source

Ribonucleic Acid Synthesis in Cells Infected with Herpes Simplex Virus: Characterization of Viral High Molecular Weight Nuclear RNA

, 1975
B. Jacquemont, Bernard Roizman
openalex   +1 more source

Apoptotic Vesicles Derived from Mesenchymal Stem Cells Ameliorate Hypersensitivity Responses via Inducing CD8+ T Cells Apoptosis with Calcium Overload and Mitochondrial Dysfunction

Advanced Science, EarlyView.
The therapeutic potential of ApoVs derived from stem cells from human exfoliated deciduous teeth (SHED‐ApoVs) in the treatment of CD8+ T cell‐mediated hypersensitivity reactions is noteworthy. SHED‐ApoVs are capable of fusing with the plasma membrane of CD8+ T cells, which subsequently triggers a series of events characterized by calcium overload ...
Anqi Liu, Peng Peng, Changze Wei, Fanhui Meng, Xiaoyao Huang, Peisheng Liu, Siyuan Fan, Xinyue Cai, Meiling Wu, Zilin Xuan, Qing Liu, Xinyu Qiu, Zhenlai Zhu, Hao Guo   +13 more
wiley   +1 more source

RNA therapy is shining for genetic diseases

Molecular Therapy: Nucleic Acids, 2023
Zhi-Ming Zheng
doaj  

Establishing an Immune System Conferring DNA and RNA Virus Resistance in Plants Using CRISPR/Cas12a Multiplex Gene Editing. [PDF]

Plant Direct
Luo L, Miao L, Ma X, Hu J, Li S, Yang W, Ma S, Chen R, Liu X.   +8 more
europepmc   +1 more source

RNA-Dependent DNA Polymerase Activity in Five RNA Viruses: Divalent Cation Requirements [PDF]

, 1970
E M Scolnick, Elaine Rands, Stuart A. Aaronson, George J. Todaro   +3 more
openalex   +1 more source

Shrimp Virus Regulates ROS Dynamics via the Nrf2 Pathway to Facilitate Viral Replication

Advanced Science, EarlyView.
Viruses manipulate host ROS as a strategy to achieve successful infection. WSSV exploits Nrf2 pathway to maintain ROS homeostasis and establishes a positive feedback loop to facilitate WSSV replication. Wsv220 competitively binds to Keap1 to activate Nrf2. Nrf2 up‐regulates LvG6PDH to produce more NADPH and GSH to eliminate excessive ROS.
Honghui He, Kai Yuan, Junming Pan, Shaoping Weng, Chaozheng Li, Yihong Chen, Jianguo He   +6 more
wiley   +1 more source

The expression profile of inflammatory microRNAs in Leishmania major infected human macrophages; mining the effects of Leishmania RNA virus. [PDF]

BMC Microbiol
Mirabedini Z, Mohebali M, Mirjalali H, Hajjaran H, Goudarzi F, Rahimi HM.   +5 more
europepmc   +1 more source

Sindbis Virus RNA Replication. I. Properties of the 38S RNA Species

, 1979
Christine W. Czarniecki, T. Sreevalsan
openalex   +1 more source