Results 191 to 200 of about 605,647 (350)

RIG‐I Mediated Neuron‐Specific IFN Type 1 Signaling in FUS‐ALS Induces Neurodegeneration and Offers New Biomarker‐Driven Individualized Treatment Options for (FUS‐)ALS

Advanced Science, EarlyView.
Using iPSC‐derived motoneurons and postmortem tissue from FUS‐ALS patients, it is demonstrated that increased mitochondrial transcription leads to elevated cytosolic double‐stranded RNA (dsRNA) levels. This aberrant accumulation activates a RIG‐I–dependent innate immune response leading to neurodegeneration, which is amenable for FDA‐ and EMA‐approved ...
Marcel Naumann, Theresa M. Wierschin, Stefanie Kretschmer, Banaja P. Dash, Aaron Held, Andrea Salzinger, Kevin Peikert, Anže Karlek, Hannes Glaß, Dajana Großmann, René Günther, Susanne Petri, Annekathrin Rödiger, David Brenner, Francisco Pan‐Montojo, Eleonora Aronica, Markus Kipp, Vitaly Zimyanin, Jared Sterneckert, Torsten Grehl, Noah D. Seebacher, Tobias M. Böckers, Alberto Catanese, Brian J. Wainger, Patrick Oeckl, Min Ae Lee‐Kirsch, Andreas Hermann   +26 more
wiley   +1 more source

The porcine reproductive and respiratory syndrome [PDF]

, 1993
Albina, E., Benfield, D., Conzelmann, Karl-Klaus, Drew, T. W., Meulenberg, J. J. M., Murtaugh, M., Nelson, E. A., Thiel, Heinz-Jürgen, Wensvoort, G.   +8 more
core   +1 more source

Qualitative hepatitis C virus RNA assay identifies active infection with sufficient viral load for treatment among Phetchabun residents in Thailand [PDF]

, 2022
Pornpitra Pratedrat, Pornjarim Nilyanimit, Rujipat Wasitthankasem, Nawarat Posuwan, Chompoonut Auphimai, Payuda Hansoongnern, Napaporn Pimsing, Saranya Ngamnimit, Chaiwat Thongmai, Wijittra Phaengkha, Nasamon Wanlapakorn, Sompong Vongpunsawad, Yong Poovorawan   +12 more
openalex   +1 more source

Circular RNA PTPN4 Contributes to Blood‐Brain Barrier Disruption during Early Epileptogenesis

Advanced Science, EarlyView.
Epileptic condition induces CircPTPN4 upregulation, which promotes ECE‐1 expression through competitive sequestration of miR‐145a‐5p. The elevated ECE‐1 catalyzes the ET‐1 production, leading to p38/MAPK pathway activation and subsequent downregulation of tight junction protein expression. This cascade results in increased BBB permeability and enhanced
Jiurong Yang, Yang Hu, Feiyu Wang, Xintao Peng, Honggang Qi, Yuanyuan Yao, Canyu Zhang, Lijie Zhou, Xuemei Liang, Kang Xu, Cong Zhang, Aifeng Zhang, Chen Chen, Yu Zeng, Chenchen Zhang, Guangming Gan, Xinjian Zhu   +16 more
wiley   +1 more source

IFN alpha inducible protein 27 (IFI27) acts as a positive regulator of PACT-dependent PKR activation after RNA virus infections. [PDF]

PLoS Pathog
López-García D, Rivero V, Villamayor L, DeDiego ML.   +3 more
europepmc   +1 more source

Nucleosides for the treatment of respiratory RNA virus infections. [PDF]

Antivir Chem Chemother, 2018
Jordan PC, Stevens SK, Deval J.
europepmc   +1 more source

Kinetics of human immunodeficiency virus type 1 (HIV-1) DNA and RNA synthesis during primary HIV-1 infection.

, 1993
Cecilia Graziosi, Giuseppe Pantaleo, Luca Butini, James F. Demarest, Michael S. Saag, George M. Shaw, A S Fauci   +6 more
openalex   +2 more sources

Delta Opioid Receptors within the Cortico‐Thalamic Circuitry Underlie Hyperactivity Induced by High‐Dose Morphine

Advanced Science, EarlyView.
Morphine activates the excitatory cingulate cortex–intermediate rostrocaudal division of zona incerta (Cg‐ZIm) pathway to drive hyperlocomotion in mice. Inhibiting the Cg‐ZIm pathway attenuates both acute and chronic morphine‐induced hyperlocomotion, while its activation mimics morphine's motor effects.
Chun‐Yue Li, Huiqian Huang, Xiao‐Fan Shen, Ke‐Lei Cao, Di Zheng, Yi Zhu, Shi‐Ze Xie, Xiao‐Dan Yu, Hao Wang, Jia‐Dong Chen, Jie Shi, Yue Li, Min Yan, Xiao‐Ming Li   +13 more
wiley   +1 more source

Persistent RNA virus infections: do PAMPS drive chronic disease? [PDF]

Curr Opin Virol, 2017
McCarthy MK, Morrison TE.
europepmc   +1 more source

Apoptotic metabolites synthesize and inherit unique de novo L2a/L2b RNAs to prevent virus infection

Peiyi Li, Yue Lan, Xutong Yan, Zeyuan Cao, Jingyun Ji, Mingqiang Deng, Dongmei He, Ruoxin Huang, Yan Qu, Yaoxing Wu, Xinchun Zhang, Jun Cui, Guan‐Zheng Luo, Xichen Bao, Songtao Shi   +14 more
openalex   +1 more source