Results 81 to 90 of about 447,697 (355)

Nipah virus vector sequences in COVID-19 patient samples sequenced by the Wuhan Institute of Virology [PDF]

arXiv, 2021
We report the detection of Nipah virus in an infectious clone format, a BSL4-level pathogen and CDC-designated Bioterrorism Agent, in raw RNA-Seq sequencing reads deposited by the Wuhan Institute of Virology (WIV) produced from five December 2019 patients infected with SARS-CoV-2.
arxiv  

Hepatitis C virus genotypes in liver transplant recipients: Impact on posttransplant recurrence, infections, response to interferon-α therapy and outcome [PDF]

, 1997
Background. End-stage liver disease due to hepatitis C virus (HCV) is the most common indication for liver transplantation in U.S. veterans. We investigated the influence of HCV genotypes on the incidence and timing of recurrent HCV hepatitis, survival ...
Fung, JJ, Gayowski, T, Laskus, T, Marino, IR, Morelli, F, Rakela, J, Singh, N, Starzl, TE, Vargas, H, Wagener, M, Wannstedt, C   +10 more
core   +1 more source

Evolutionary interplay between viruses and R‐loops

FEBS Letters, EarlyView.
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi, Zita Képes, Zoltán Szabó, Eszter Csoma, Lóránt Székvölgyi   +4 more
wiley   +1 more source

Isolation of poliovirus 2C mutants defective in viral RNA synthesis [PDF]

, 1988
Two poliovirus mutants were isolated that contain an oligonucleotide linker insertion in the 2C-coding region of the viral genome. One, 2C-31, has a strongly temperature-sensitive phenotype and the other, 2C-32, forms small plaques on HeLa cell ...
Baltimore, David, Li, Jing-Po
core  

Dengue Virus Genome Uncoating Requires Ubiquitination [PDF]

, 2016
The process of genome release or uncoating after viral entry is one of the least-studied steps in the flavivirus life cycle. Flaviviruses are mainly arthropod-borne viruses, including emerging and reemerging pathogens such as dengue, Zika, and West Nile ...
Byk, Laura Andrea, de Maio, Federico Andres, Gamarnik, Andrea Vanesa, Gebhard, Leopoldo German, Iglesias, Nestor Gabriel, Rossi, Mario   +5 more
core   +3 more sources

Inhibition of influenza virus production in virus-infected mice by RNA interference [PDF]

Proceedings of the National Academy of Sciences, 2004
Influenza A virus infection is a major source of morbidity and mortality worldwide. Because the effectiveness of existing vaccines and antiviral drugs is limited, development of new treatment modalities is needed. Here, we show that short interfering RNAs (siRNAs) specific for conserved regions of influenza virus genes can prevent and treat influenza ...
Ailin Bai, Qing Ge, Lily Filip, Jianzhu Chen, Tam Nguyen, Herman N. Eisen   +5 more
openaire   +3 more sources

Subpar reporting of pre‐analytical variables in RNA‐focused blood plasma studies

Molecular Oncology, EarlyView.
Pre‐analytical variables strongly influence the analysis of extracellular RNA (cell‐free RNA; exRNA) derived from blood plasma. Their reporting is essential to allow interpretation and replication of results. By evaluating 200 exRNA studies, we pinpoint a lack of reporting pre‐analytical variables associated with blood collection, plasma preparation ...
Céleste Van Der Schueren, Philippe Decruyenaere, Francisco Avila Cobos, Johanna Bult, Jill Deleu, Laudonia Lidia Dipalo, Hetty Hilde Helsmoortel, Eva Hulstaert, Annelien Morlion, Elena Ramos Varas, Kathleen Schoofs, Wim Trypsteen, Eveline Vanden Eynde, Hanne Van Droogenbroeck, Kimberly Verniers, Jo Vandesompele, Anneleen Decock   +16 more
wiley   +1 more source

Stochastic Modeling and Simulation of Viral Evolution [PDF]

Bulletin of Mathematical Biology, Volume 81, April 2019, 1031-1069, 2017
RNA viruses comprise vast populations of closely related, but highly genetically diverse, entities known as quasispecies. Understanding the mechanisms by which this extreme diversity is generated and maintained is fundamental when approaching viral persistence and pathobiology in infected hosts.
arxiv   +1 more source

Defective interfering viral particles in acute dengue infections. [PDF]

PLoS ONE, 2011
While much of the genetic variation in RNA viruses arises because of the error-prone nature of their RNA-dependent RNA polymerases, much larger changes may occur as a result of recombination.
Dongsheng Li, William B Lott, Kym Lowry, Anita Jones, Hlaing Myat Thu, John Aaskov   +5 more
doaj   +1 more source

A New Strategy of Cross-Protection Based on Attenuated Vaccines: RNA Viruses Are Used as Vectors to Control DNA Viruses

Agronomy, 2023
Plant viruses can infect various types of plants, including food and oil crops, and ornamental flowers, threatening agricultural production and food supply. Cross-protection is an efficient strategy against severe viral strains. Due to distinct infection
Mingjing Zhu, Shanshan Liu, Zhao Wang, Chengming Yu, Xuefeng Yuan   +4 more
doaj   +1 more source