Results 71 to 80 of about 2,976,975 (155)

Activation of the interferon induction cascade by influenza A viruses requires viral RNA synthesis and nuclear export [PDF]

, 2014
This work is supported by grants from the Wellcome Trust (grants 087751/A/08/Z) and MRC (G1001726/1).We have examined the requirements for virus transcription and replication and thus the roles of input and progeny genomes in the generation of interferon
Randall, Richard E, Smith, Matt, Killip, Marian J, Jackson, David, Randall, Richard E; id_orcid   +4 more
core   +1 more source

Importin-α-mediated nucleolar localization of potato mop-top virus TRIPLE GENE BLOCK1 (TGB1) protein facilitates virus systemic movement, whereas TGB1 self-interaction is required for cell-to-cell movement in Nicotiana benthamiana [PDF]

, 2015
This work was supported by the Swedish Research Council Formas (to E.I.S.), the Carl Tryggers Foundation (to E.I.S. and N.I.L.), the Swedish Institute (to N.I.L.), and the Rural and Environmental Science and Analytical Services Division strategic ...
Savenkov, Eugene I., Cowan, Graham H., Lukhovitskaya, Nina I., Tilsner, Jens, Torrance, Lesley, Vetukuri, Ramesh R., Cowan, Graham H,, Vetukuri, Ramesh,, Sveriges lantbruksuniversitet., Ramesh, Vetukuri,, Swedish University of Agricultural Sciences., Torrance, Lesley,, Savenkov, Eugene,, Lukhovitskaya, Nina,, Tilsner, Jens; id_orcid   +14 more
core   +1 more source

Modulation of immune responses by human paraininfluenza virus [PDF]

, 2007
Human Parainfluenza virus type 3 (HPIV3) is a key respiratory pathogen responsible for bronchiolitis, pneumonia and croup. The persistent nature of this virus and its ability to reinfect within a short space of time has led to successive failures in the ...
Noone, Cariosa
core   +2 more sources

In vivo evidence for quasispecies distributions in the bovine respiratory syncytial virus genome [PDF]

, 2007
We analyzed the genetic evolution of bovine respiratory syncytial virus (BRSV) isolate W2-00131, from its isolation in bovine turbinate (BT) cells to its inoculation in calves.
Mirandette, Carole, Schelcher, François, Bonnet, Marion, Meyer, Gilles, Deplanche, Martine, Lemaire, Mylène   +5 more
core   +1 more source

Proteomic analysis of mitochondrial-associated ER membranes (MAM) during RNA virus infection reveals dynamic changes in protein and organelle trafficking.

PLoS ONE, 2015
RIG-I pathway signaling of innate immunity against RNA virus infection is organized between the ER and mitochondria on a subdomain of the ER called the mitochondrial-associated ER membrane (MAM).
Stacy M Horner, Courtney Wilkins, Samantha Badil, Jason Iskarpatyoti, Michael Gale   +4 more
doaj   +1 more source

A virulent strain of deformed wing virus (DWV) of honeybees (Apis mellifera) prevails after varroa destructor-mediated, or in vitro, transmission [PDF]

, 2014
The globally distributed ectoparasite Varroa destructor is a vector for viral pathogens of the Western honeybee (Apis mellifera), in particular the Iflavirus Deformed Wing Virus (DWV).
James C Bull, Jonathan D. Moore (262014), Fannon, Jessica, Jonathan D. Moore, Dave Ch, Graham R Wood, James C. Bull¤a, Fannon, Jessica M., Jessica M Fannon, Mead, Andrew, Jessica M. Fannon (589359), James C. Bull (107677), Nigel Burroughs (589360), David J. Evans (208308), Graham R. Wood, Nigel Burroughs, David J. Evans, Ryabov, Eugene V., Wood, Graham R., Chandler, Dave, Eugene V. Ryabov (107680), Mead, A. (Andrew), Eugene V Ryabov, Andrew Mead, David J Evans, Jonathan D Moore, Moore, Jonathan D., Wood, Graham, Bull, James C., Burroughs, Nigel, Graham R. Wood (589358), Dave Chandler (107700), Dave Chandler, Jessica M. Fannon, Andrew Mead (107686), Bull, James C. (James Christopher), Burroughs, Nigel John, Evans, David J., Eugene V. Ryabov, Bull James C., Burroughs Nigel, Evans David J., Moore Jonathan D., Chandler Dave, Ryabov Eugene V., James Bull, Mead Andrew, Wood Graham R., Fannon Jessica M., Evans, David J.; id_orcid   +49 more
core   +2 more sources

Cas13d-mediated viral RNA degradation leads to potent antiviral control against both positive and negative sense RNA viruses

Molecular Therapy: Nucleic Acids
Respiratory viral infections continue to pose a substantial global health challenge, with a pressing need for effective treatment options. The rapid mutation rate of RNA viruses presents a significant risk of escape from existing treatments.
Pimpan Sujariyakul, Lucia Amurri, Anna Carolina Henkel, Maureen Obara, Sebastian Hook, Andreas Pavlou, Vanessa Hamann, Matthias Bruhn, Marie Ruhe, Martin Kohn, Mathieu Iampietro, Heiner Wedemeyer, Branka Horvat, Ulrich Kalinke, Michael Ott, Jens Bohne, Simon Alexander Krooss   +16 more
doaj   +1 more source

New Kids on the Block: RNA-Based Influenza Virus Vaccines

Vaccines, 2018
RNA-based immunization strategies have emerged as promising alternatives to conventional vaccine approaches. A substantial body of published work demonstrates that RNA vaccines can elicit potent, protective immune responses against various pathogens ...
Francesco Berlanda Scorza, Norbert Pardi
doaj   +1 more source

Reduction of HIV-1 RNA levels with therapy to suppress herpes simplex virus. [PDF]

, 2007
BACKGROUND: Epidemiologic data suggest that infection with herpes simplex virus type 2 (HSV-2) is associated with increased genital shedding of human immunodeficiency virus type 1 (HIV-1) RNA and HIV-1 transmissibility. METHODS: We conducted a randomized,
Becquart, Pierre, Van de Perre, Philippe, Sanon, Anselme, Segondy, Michel, Weiss, Helen A, Andonaba, Jean-Baptiste, Vallo, Roselyne, ANRS 1285 Study Group, Sawadogo, Adrien, Nagot, Nicolas, Foulongne, Vincent, Vergne, Laurence, Mayaud, Philippe, Ouédraogo, Abdoulaye, Defer, Marie-Christine, Djagbaré, Didier, Konaté, Issouf   +16 more
core   +1 more source

Mixed viral infections uncover multifaceted RNA silencing strategies in plant antiviral defense

BMC Genomics
Background Alphanecrovirus tessellati and Alphanecrovirus oleae are closely related alphanecroviruses, sharing over 74% genomic identity and frequently co-infecting plants under natural conditions.
Patrick Materatski, Joana Amaro Ribeiro, Cristiana Marques, André Albuquerque, Maria do Rosário Félix, Carla Varanda   +5 more
doaj   +1 more source