Results 61 to 70 of about 441,359 (251)

Toward a Categorization of Virus-ncRNA Interactions in the World of RNA to Disentangle the Tiny Secrets of Dengue Virus

Viruses
In recent years, the function of noncoding RNAs (ncRNAs) as regulatory molecules of cell physiology has begun to be better understood. Advances in viral molecular biology have shown that host ncRNAs, cellular factors, and virus-derived ncRNAs and their ...
Clara Isabel Bermudez-Santana, Juan Carlos Gallego-Gómez   +1 more
doaj   +1 more source

Roles and Applications of Circular RNA in Virus Infection

International Journal of Molecular Sciences
Circular RNAs (circRNAs) are novel types of covalently closed single-stranded RNA formed by the backsplicing of precursor mRNAs (pre-mRNAs). Recently, circRNAs have been shown to play a crucial role in various diseases, including cancers, cardiovascular and cerebrovascular diseases, and autoimmune diseases.
Fang Gou, Yanmei Gao, Keke Zhong, Tian Bu, Yinggang Li, Faxiang Li, Rong Yang   +6 more
openaire   +2 more sources

Inhibition of influenza virus production in virus-infected mice by RNA interference [PDF]

Proceedings of the National Academy of Sciences, 2004
Influenza A virus infection is a major source of morbidity and mortality worldwide. Because the effectiveness of existing vaccines and antiviral drugs is limited, development of new treatment modalities is needed. Here, we show that short interfering RNAs (siRNAs) specific for conserved regions of influenza virus genes can prevent and treat influenza ...
Qing, Ge, Lily, Filip, Ailin, Bai, Tam, Nguyen, Herman N, Eisen, Jianzhu, Chen   +5 more
openaire   +2 more sources

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Therapeutic Potential of CRISPR-Cas13 for RNA Virus Infections

Galician Medical Journal
CRISPR-Cas13 is a groundbreaking RNA-targeting tool that has emerged as a promising solution for diagnosing and treating RNA viruses, including SARS-CoV-2, influenza, and HIV.
Sharanagouda S. Patil, Krishna Prasanth Baalann, Danti Joseph, Sriram N, Nirmali Gogoi   +4 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Evaluating anti-CHIK IgM and qualitative RT-PCR for diagnosing chikungunya in hospitalized patients: A comparative analysis of diagnostic efficacy

Journal of Vector Borne Diseases
Background & objectives: Chikungunya virus (CHIKV) is an alphavirus characterized by a positive-sense, single-stranded RNA genome, and it is transmitted primarily by Aedes mosquitoes.
Mohd Afzal, Abhishek Sharma, Ashok Kumar Sah, M Chandrasekar   +3 more
doaj   +1 more source

RNA-Dependent RNA Polymerase in Nuclei of Cells Infected with Influenza Virus [PDF]

Journal of Virology, 1973
Nuclei purified from chicken embryo fibroblast cells infected with influenza (fowl plague) virus contain an RNA-dependent RNA polymerase. The in vitro activity of this enzyme is insensitive to actinomycin D, and is completely destroyed by preincubation with ribonuclease.
N D, Hastie, B W, Mahy
openaire   +2 more sources

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source