Results 41 to 50 of about 445,400 (250)

Innate Immune Response to RNA Virus Infections

Uirusu, 2011
Viral RNA is recognized by RIG-I-like receptors and Toll-like receptors. RIG-I is a cytoplasmic viral RNA sensor. High Mobility Group Box (HMGB) proteins and DExD/H box RNA helicases, such as DDX3 and 60, associate with viral RNA. Those proteins promotes the RIG-I binding to viral RNA. RIG-I triggers the signal via IPS-1 adaptor molecule to induce type
OSHIUMI, Hiroyuki, MATSUMOTO, Misako, SEYA, Tsukasa   +2 more
openaire   +3 more sources

Distinct evolution of SARS-CoV-2 Omicron XBB and BA.2.86/JN.1 lineages combining increased fitness and antibody evasion

Nature Communications
The unceasing circulation of SARS-CoV-2 leads to the continuous emergence of novel viral sublineages. Here, we isolate and characterize XBB.1, XBB.1.5, XBB.1.9.1, XBB.1.16.1, EG.5.1.1, EG.5.1.3, XBF, BA.2.86.1 and JN.1 variants, representing >80% of ...
Delphine Planas, Isabelle Staropoli, Vincent Michel, Frederic Lemoine, Flora Donati, Matthieu Prot, Francoise Porrot, Florence Guivel-Benhassine, Banujaa Jeyarajah, Angela Brisebarre, Océane Dehan, Léa Avon, William Henry Bolland, Mathieu Hubert, Julian Buchrieser, Thibault Vanhoucke, Pierre Rosenbaum, David Veyer, Hélène Péré, Bruno Lina, Sophie Trouillet-Assant, Laurent Hocqueloux, Thierry Prazuck, Etienne Simon-Loriere, Olivier Schwartz   +24 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Temperature-dependent replication and sensitivity to innate immunity of human coronavirus HKU1

Nature Communications
The human coronavirus HKU1, causing common colds and occasionally severe illness, remains largely uncharacterized because it has not been successfully grown on immortalized cells.
Julian Buchrieser, Eva Thuillier, Jeanne Postal, Amélie Wileveau, Florence Guivel-Benhassine, Isabelle Staropoli, Nell Saunders, Delphine Planas, Jamie Sugrue, Vincent Bondet, Ignacio Fernández, François Bontems, Françoise Porrot, Chloé Petiot, Matthieu Prot, Martin Jungbauer-Groznica, Laurence Arowas, Vincent Michel, Catherine Blanc, Sophie Trouillet-Assant, Timothée Bruel, Félix A. Rey, Marie-Anne Rameix-Welti, Nicoletta Casartelli, Arnaud Fontanet, Michael White, Darragh Duffy, Etienne Simon-Lorière, Olivier Schwartz   +28 more
doaj   +1 more source

Nora virus persistent infections are not affected by the RNAi machinery. [PDF]

PLoS ONE, 2009
Drosophila melanogaster is widely used to decipher the innate immune system in response to various pathogens. The innate immune response towards persistent virus infections is among the least studied in this model system. We recently discovered a picorna-
Mazen S Habayeb, Jens-Ola Ekström, Dan Hultmark   +2 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Prevalence of dengue, chikungunya and zika viruses in blood donors in Kunming, China

Zhongguo shuxue zazhi
Objective To investigate the prevalence of zika virus (ZIKV), dengue virus (DENV) and chikungunya virus (CHIKV) infections in blood donors in Kunming, China.
ZHANG Zhihui, LI Qian, PENG Mozhen, LUO Zhen, CHEN Lu, GAO Lili, CUN Wei, DU Xia   +7 more
doaj   +1 more source

Detection of Multiple Potato Viruses in the Field Suggests Synergistic Interactions among Potato Viruses in Pakistan

The Plant Pathology Journal, 2014
Viral diseases have been a major limiting factor threating sustainable potato (Solanum tuberosum L.) production in Pakistan. Surveys were conducted to serologically quantify the incidence of RNA viruses infecting potato; Potato virus X (PVX), Potato ...
Amir Hameed, Zafar Iqbal, Shaheen Asad, Shahid Mansoor   +3 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source