Results 51 to 60 of about 2,976,975 (155)

Activation of influenza virus RNA polymerase by the 5' and 3' terminal duplex of genomic RNA [PDF]

, 2003
The current model for influenza virus mRNA transcription involves the sequential interaction of the viral polymerase with the 5'- and 3'-ends of vRNA, with each RNA-protein interaction triggering a polymerase function necessary for cap-primed ...
Tiley, Laurence, Klumpp, Klaus, Digard, Paul, Lee, Michael T, M.-T. M. Lee   +4 more
core   +2 more sources

A novel broad-spectrum treatment for respiratory virus infections : influenza-based defective interfering virus provides protection against pneumovirus infection in vivo [PDF]

, 2011
Respiratory viruses represent a major clinical burden. Few vaccines and antivirals are available, and the rapid appearance of resistant viruses is a cause for concern.
Edworthy, Nicole Lynn, Nicole L. Edworthy, Andrew J. Easton, Meng, Bo, Easton, A. J. (Andrew J.), Bo Meng, Scott, P. D. (Paul D.), Marriott, Anthony C., Anthony C. Marriott, Nigel J. Dimmock, Dimmock, N. J., Paul D. Scott   +11 more
core   +1 more source

Impaired antibody response causes persistence of prototypic T cell-contained virus [PDF]

, 2009
CD8 T cells are recognized key players in control of persistent virus infections, but increasing evidence suggests that assistance from other immune mediators is also needed. Here, we investigated whether specific antibody responses contribute to control
André Fitsche, Bruno Eschli, Lukas Flatz, Senn, Beatrice M., Marylise Fernandez, Ahmed N Hegazy, Verbeek, J Sjef, Eschli, Bruno, Fink, Katja, Rami Sommerstein, Doron Merkler, Daniel D Pinschewer, Katja Fink, Siegrist, Claire-Anne, Odermatt, Bernhard, Andreas Bergthaler, Horvath, Edit, Fitsche, André, Bergthaler, Andreas, Claire-Anne Siegrist, Holdener, Martin, Beatrice M Senn, Verbeek, J. Sjef, Admar Verschoor, J Sjef Verbeek, Verschoor, Admar, Merkler, Doron, Edit Horvath, Pinschewer, Daniel, Martin Holdener, Bernhard Odermatt, Flatz, Lukas, Pinschewer, Daniel D., Sommerstein, Rami, Hegazy, Ahmed N., Fernandez, Marylise, Merkler D, Verbeek JS, Siegrist CA, Fitsche A, Flatz L, Verschoor A, Holdener M, Bergthaler, A;Flatz, L;Verschoor, A;Hegazy, AN;Holdener, M;Fink, K;Eschli, B;Merkler, D;Sommerstein, R;Horvath, E;Fernandez, M;Fitsche, A;Senn, BM;Verbeek, JS;Odermatt, B;Siegrist, CA;Pinschewer, DD, Senn BM, Pinschewer DD, Odermatt B, Sommerstein R, Fernandez M, Fink K, Eschli B, Bergthaler A, Hegazy AN, Horvath E   +53 more
core   +1 more source

Cell-free (RNA) and cell-associated (DNA) HIV-1 and postnatal transmission through breastfeeding [PDF]

, 2012
<p>Introduction - Transmission through breastfeeding remains important for mother-to-child transmission (MTCT) in resource-limited settings. We quantify the relationship between cell-free (RNA) and cell-associated (DNA) shedding of HIV-1 virus in ...
Van de Perre, P, James Ndirangu, Ndirangu James, Ruth M. Bland, Van de Perre Philippe, Ruth M Bland, Thorne, C., Danaviah, S, Thorne Claire, Newell Marie-Louise, Newell, M.-L., Viljoen, J., Ndirangu, J., Newell, M-L, Thorne, C, Van de Perre, P., Danaviah Siva, Bland, R.M., Philippe Van de Perre, Viljoen, J, Marie-Louise Newell, Ndirangu, J, Claire Thorne, Bland, RM, Danaviah, S., Siva Danaviah, Viljoen Johannes, Bland Ruth M., Johannes Viljoen   +28 more
core   +1 more source

Dampening of ISGylation of RIG-I by ADAP regulates type I interferon response of macrophages to RNA virus infection.

PLoS Pathogens
While macrophage is one of the major type I interferon (IFN-I) producers in multiple tissues during viral infections, it also serves as an important target cell for many RNA viruses. However, the regulatory mechanism for the IFN-I response of macrophages
Yan Wang, Haixia Feng, Xiao Li, Yina Ruan, Yueping Guo, Xinxing Cui, Pengchao Zhang, Yanli Li, Xinning Wang, Xingran Wang, Luxin Wei, Yulan Yi, Lifeng Zhang, Xiaodong Yang, Hebin Liu   +14 more
doaj   +1 more source

Influenza Virus RNA Synthesis and the Innate Immune Response

Viruses, 2021
Infection with influenza A and B viruses results in a mild to severe respiratory tract infection. It is widely accepted that many factors affect the severity of influenza disease, including viral replication, host adaptation, innate immune signalling ...
Sabrina Weis, Aartjan J. W. te Velthuis
doaj   +1 more source

The influence of viral RNA secondary structure on interactions with innate host cell defences [PDF]

, 2013
RNA viruses infecting vertebrates differ fundamentally in their ability to establish persistent infections with markedly different patterns of transmission, disease mechanisms and evolutionary relationships with their hosts.
Blundell, Richard, Richard Blundell, Nora McFadden, Joris J. Maarleveld, Maarleveld, Joris J, Evans, David J, Simmonds, Peter, Jeroen Witteveldt, Maarleveld, Joris J., David J. Evans, McFadden, Nora, Peter Simmonds, Evans, David J., Witteveldt, Jeroen, Evans, David J.; id_orcid   +14 more
core   +1 more source

Histone demethylase LSD1 restricts influenza A virus infection by erasing IFITM3-K88 monomethylation. [PDF]

PLoS Pathogens, 2017
The histone demethylase LSD1 has been known as a key transcriptional coactivator for DNA viruses such as herpes virus. Inhibition of LSD1 was found to block viral genome transcription and lytic replication of DNA viruses.
Jiaoyu Shan, Binbin Zhao, Zhao Shan, Jia Nie, Rong Deng, Rui Xiong, Andy Tsun, Weiqi Pan, Hanzhi Zhao, Ling Chen, Ying Jin, Zhikang Qian, Kawing Lui, Rui Liang, Dan Li, Bing Sun, Dimitri Lavillette, Ke Xu, Bin Li   +18 more
doaj   +1 more source

Toward a Categorization of Virus-ncRNA Interactions in the World of RNA to Disentangle the Tiny Secrets of Dengue Virus

Viruses
In recent years, the function of noncoding RNAs (ncRNAs) as regulatory molecules of cell physiology has begun to be better understood. Advances in viral molecular biology have shown that host ncRNAs, cellular factors, and virus-derived ncRNAs and their ...
Clara Isabel Bermudez-Santana, Juan Carlos Gallego-Gómez   +1 more
doaj   +1 more source

Mechanisms of resistance to viruses

Plant Protection Science, 2002
Resistance associated with a hypersensitive response (HR) and subsequent development of necrotic lesions (cell death) at the sites of virus infection can restrict virus movement in plants. Genes for HR are dominant and act on a gene-for-gene basis.
J.P.T. Valkonen
doaj   +1 more source