Results 21 to 30 of about 441,359 (251)

A selective autophagy receptor VISP1 induces symptom recovery by targeting viral silencing suppressors

Nature Communications, 2023
Selective autophagy is a double-edged sword in antiviral immunity and regulated by various autophagy receptors. However, it remains unclear how to balance the opposite roles by one autophagy receptor.
Xin Tong, Jia-Jia Zhao, Ya-Lan Feng, Jing-Ze Zou, Jian Ye, Junfeng Liu, Chenggui Han, Dawei Li, Xian-Bing Wang   +8 more
doaj   +1 more source

Viral suppressors from members of the family Closteroviridae combating antiviral RNA silencing: a tale of a sophisticated arms race in host-pathogen interactions

Phytopathology Research, 2021
RNA silencing is an evolutionarily homology-based gene inactivation mechanism and plays critical roles in plant immune responses to acute or chronic virus infections, which often pose serious threats to agricultural productions.
Muhammad Dilshad Hussain, Tahir Farooq, Xi Chen, Muhammad Tariqjaveed, Tong Jiang, Sijia Liu, Tao Zhou   +6 more
doaj   +1 more source

Discovery and Community Dynamics of Novel ssRNA Mycoviruses in the Conifer Pathogen Heterobasidion parviporum

Frontiers in Microbiology, 2021
Heterobasidion species are highly destructive basidiomycetous conifer pathogens of the Boreal forest region. Earlier studies have revealed dsRNA virus infections of families Curvulaviridae and Partitiviridae in Heterobasidion strains, and small RNA deep ...
Suvi Sutela, Tuula Piri, Eeva J. Vainio
doaj   +1 more source

Dual Effect of Organogermanium Compound THGP on RIG-I-Mediated Viral Sensing and Viral Replication during Influenza a Virus Infection

Viruses, 2021
The interaction of viral nucleic acid with protein factors is a crucial process for initiating viral polymerase-mediated viral genome replication while activating pattern recognition receptor (PRR)-mediated innate immune responses. It has previously been
Sunanda Baidya, Yoko Nishimoto, Seiichi Sato, Yasuhiro Shimada, Nozomi Sakurai, Hirotaka Nonaka, Koki Noguchi, Mizuki Kido, Satoshi Tadano, Kozo Ishikawa, Kai Li, Aoi Okubo, Taisho Yamada, Yasuko Orba, Michihito Sasaki, Hirofumi Sawa, Hiroko Miyamoto, Ayato Takada, Takashi Nakamura, Akinori Takaoka   +19 more
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Immune responses to RNA virus infections of the CNS [PDF]

BMC Proceedings, 2003
A successful outcome for the host of virus infection of the central nervous system (CNS) requires the elimination of the virus without damage to essential non-renewable cells, such as neurons. As a result, inflammatory responses must be tightly controlled, and many unique mechanisms seem to contribute to this control.
openaire   +3 more sources

BCX4430 – A broad-spectrum antiviral adenosine nucleoside analog under development for the treatment of Ebola virus disease

Journal of Infection and Public Health, 2016
Summary: The adenosine nucleoside analog BCX4430 is a direct-acting antiviral drug under investigation for the treatment of serious and life-threatening infections from highly pathogenic viruses, such as the Ebola virus.
Raymond Taylor, Pravin Kotian, Travis Warren, Rekha Panchal, Sina Bavari, Justin Julander, Sylvia Dobo, Angela Rose, Yahya El-Kattan, Brian Taubenheim, Yarlagadda Babu, William P. Sheridan   +11 more
doaj   +1 more source

Virus-host protein-protein interactions as molecular drug targets for arboviral infections

Frontiers in Virology, 2022
Arboviruses have the potential to spread quickly and cause a global health emergency. These are RNA viruses that use RNA-dependent RNA polymerase (RdRp) for their replication. RdRp lacks proofreading activity, leading to high error rates, low replicative
Mandar Bhutkar, Vishakha Singh, Preeti Dhaka, Shailly Tomar   +3 more
doaj   +1 more source

Plant RNA Regulatory Network and RNA Granules in Virus Infection [PDF]

Frontiers in Plant Science, 2017
Regulation of post-transcriptional gene expression on mRNA level in eukaryotic cells includes translocation, translation, translational repression, storage, mRNA decay, RNA silencing, and nonsense-mediated decay. These processes are associated with various RNA-binding proteins and cytoplasmic ribonucleoprotein complexes many of which are conserved ...
Kristiina Mäkinen, Andres Lõhmus, Maija Pollari   +2 more
openaire   +3 more sources

RNA Virus Gene Signatures Detected in Patients With Cardiomyopathy After Chemotherapy; A Pilot Study

Frontiers in Cardiovascular Medicine, 2022
BackgroundViral infections are pervasive and leading causes of myocarditis. Immune-suppression after chemotherapy increases opportunistic infections, but the incidence of virus-induced myocarditis is unknown.ObjectiveAn unbiased, blinded screening for ...
Kyle Varkoly, Kyle Varkoly, Shaoyuan Tan, Roxana Beladi, Roxana Beladi, David Fonseca, Isabela Rivabem Zanetti, Simona Kraberger, Chintan Shah, Jordan R. Yaron, Jordan R. Yaron, Liqiang Zhang, Michael Juby, Ayman Fath, Sriram Ambadapadi, Melanie House, Paul Maranian, Carl J. Pepine, Arvind Varsani, Arvind Varsani, Jan Moreb, Stacey Schultz-Cherry, Alexandra R. Lucas, Alexandra R. Lucas, Alexandra R. Lucas   +24 more
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Use of Unamplified RNA/cDNA–Hybrid Nanopore Sequencing for Rapid Detection and Characterization of RNA Viruses

Emerging Infectious Diseases, 2016
Nanopore sequencing, a novel genomics technology, has potential applications for routine biosurveillance, clinical diagnosis, and outbreak investigation of virus infections. Using rapid sequencing of unamplified RNA/cDNA hybrids, we identified Venezuelan
Andy Kilianski, Pierce A. Roth, Alvin T. Liem, Jessica M. Hill, Kristen L. Willis, Rebecca D. Rossmaier, Andrew V. Marinich, Michele N. Maughan, Mark A. Karavis, Jens H. Kuhn, Anna N. Honko, C. Nicole Rosenzweig   +11 more
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