Results 21 to 30 of about 2,976,975 (155)

Dual Effect of Organogermanium Compound THGP on RIG-I-Mediated Viral Sensing and Viral Replication during Influenza a Virus Infection

Viruses, 2021
The interaction of viral nucleic acid with protein factors is a crucial process for initiating viral polymerase-mediated viral genome replication while activating pattern recognition receptor (PRR)-mediated innate immune responses. It has previously been
Sunanda Baidya, Yoko Nishimoto, Seiichi Sato, Yasuhiro Shimada, Nozomi Sakurai, Hirotaka Nonaka, Koki Noguchi, Mizuki Kido, Satoshi Tadano, Kozo Ishikawa, Kai Li, Aoi Okubo, Taisho Yamada, Yasuko Orba, Michihito Sasaki, Hirofumi Sawa, Hiroko Miyamoto, Ayato Takada, Takashi Nakamura, Akinori Takaoka   +19 more
doaj   +1 more source

A hepatitis C virus cis-acting replication element forms a long-range RNA-RNA interaction with upstream RNA sequences in NS5B [PDF]

, 2008
The genome of hepatitis C virus (HCV) contains cis-acting replication elements (CREs) comprised of RNA stem-loop structures located in both the 5' and 3' non-coding regions (NCR), and in the NS5B coding sequence.
Diviney, Sinéad, Elliot, R., Evans, David John, Evans, D., Armstrong, V, Tuplin, Andrew, Evans, D.J., Struthers, Madeleine, Struthers, M., Elliott, Richard M., Diviney, S., Tuplin, A., Armstrong, V., Struthers, M, Simmonds, Peter, Elliott, Richard Michael, Armstrong, Victoria, Tuplin, A, Evans, David J., Simmonds, P., Diviney, S, Elliott, R.M., Simmonds, P, Evans, David John; id_orcid   +23 more
core   +1 more source

Bacterial Infections, DNA Virus Infections, and RNA Virus Infections Manifest Differently in Neutrophil Receptor Expression

The Scientific World Journal, 2012
Treating viral illnesses or noninfective causes of inflammation with antibiotics is ineffective and contributes to the development of antibiotic resistance, toxicity, and allergic reactions, leading to increasing medical costs.
Esa-Matti Lilius, Jari Nuutila
doaj   +1 more source

BCX4430 – A broad-spectrum antiviral adenosine nucleoside analog under development for the treatment of Ebola virus disease

Journal of Infection and Public Health, 2016
Summary: The adenosine nucleoside analog BCX4430 is a direct-acting antiviral drug under investigation for the treatment of serious and life-threatening infections from highly pathogenic viruses, such as the Ebola virus.
Raymond Taylor, Pravin Kotian, Travis Warren, Rekha Panchal, Sina Bavari, Justin Julander, Sylvia Dobo, Angela Rose, Yahya El-Kattan, Brian Taubenheim, Yarlagadda Babu, William P. Sheridan   +11 more
doaj   +1 more source

Virus-host protein-protein interactions as molecular drug targets for arboviral infections

Frontiers in Virology, 2022
Arboviruses have the potential to spread quickly and cause a global health emergency. These are RNA viruses that use RNA-dependent RNA polymerase (RdRp) for their replication. RdRp lacks proofreading activity, leading to high error rates, low replicative
Mandar Bhutkar, Vishakha Singh, Preeti Dhaka, Shailly Tomar   +3 more
doaj   +1 more source

Evolution of an Eurasian avian-like influenza virus in naïve and vaccinated pigs [PDF]

, 2012
The latest human influenza pandemic highlights the ability of influenza viruses to jump species barriers and emerge in new hosts, as well as the role of pigs in generating viruses with pandemic potential.
Pablo R Murcia, Mario Caccamo, Baillie Gregory J., Gregory J. Baillie (110994), Doug Ormond (161033), Jennifer A. Mumford (161049), Grenfell Bryan T., Lloyd Lucy, Lloyd, Lucy, Battista Patrizia, Patrizia Battista, Jennifer A Mumford, Wood, James L.N., Patrizia Battista (161011), Ramirez-Gonzalez Ricardo H., Elton, Debra, Ormond Doug, Joseph Hughes (42279), Oliver Karen, Edward C. Holmes (35215), Battista, Patrizia, Holmes Edward C., Caccamo, Mario, Edward C Holmes, Wood, James L. N., Wood, James LN, Oliver, Karen, Caccamo Mario, Ricardo H Ramirez-Gonzalez, Wood James L. N., Hughes Joseph, Ricardo H. Ramirez-Gonzalez (161026), Ramirez-Gonzalez, Ricardo H., Joseph Hughes, Lucy Lloyd (161017), Murcia, Pablo R, Bryan T Grenfell, Debra Elton (29877), Ormond, Doug, Paul Kellam, Mario Caccamo (42188), Mumford Jennifer A., Murcia, Pablo R., Baillie, Gregory J., Karen Oliver, Debra Elton, Doug Ormond, Grenfell, Bryan T., Kellam Paul, Gregory J Baillie, Paul Kellam (6413), Pablo R. Murcia (111005), Murcia Pablo R., Elton Debra, Holmes, Edward C, James L. N. Wood (111001), Holmes, Edward C., Lucy Lloyd, Mumford, Jennifer A, Hughes, Joseph, Baillie, Gregory J, Mumford, Jennifer A., Karen Oliver (161040), Kellam, Paul, Grenfell, Bryan T, Ramirez-Gonzalez, Ricardo H, Bryan T. Grenfell (44234), James L N Wood   +67 more
core   +1 more source

Sequential packaging of RNA genomic segments during the assembly of Bluetongue virus. [PDF]

, 2014
Bluetongue virus (BTV), a member of the Orbivirus genus within the Reoviridae family, has a genome of 10 double-stranded RNA segments, with three distinct size classes.
Roy, Polly, Sung, Po-Yu, Po-yu Sung, Polly Roy   +3 more
core   +1 more source

Use of Unamplified RNA/cDNA–Hybrid Nanopore Sequencing for Rapid Detection and Characterization of RNA Viruses

Emerging Infectious Diseases, 2016
Nanopore sequencing, a novel genomics technology, has potential applications for routine biosurveillance, clinical diagnosis, and outbreak investigation of virus infections. Using rapid sequencing of unamplified RNA/cDNA hybrids, we identified Venezuelan
Andy Kilianski, Pierce A. Roth, Alvin T. Liem, Jessica M. Hill, Kristen L. Willis, Rebecca D. Rossmaier, Andrew V. Marinich, Michele N. Maughan, Mark A. Karavis, Jens H. Kuhn, Anna N. Honko, C. Nicole Rosenzweig   +11 more
doaj   +1 more source

Generation and characterization of a recombinant Rift Valley fever virus expressing a V5 epitope-tagged RNA-dependent RNA polymerase [PDF]

, 2011
The viral RNA-dependent RNA polymerase (RdRp; L protein) of Rift Valley fever virus (RVFV; family Bunyaviridae) is a 238 kDa protein that is crucial for the life cycle of the virus, as it catalyses both transcription of viral mRNAs and replication of the
Brennan, Benjamin, Richard M. Elliott, Li, Ping, Ping Li, Elliott, Richard M., Benjamin Brennan   +5 more
core   +1 more source

RNA Virus Gene Signatures Detected in Patients With Cardiomyopathy After Chemotherapy; A Pilot Study

Frontiers in Cardiovascular Medicine, 2022
BackgroundViral infections are pervasive and leading causes of myocarditis. Immune-suppression after chemotherapy increases opportunistic infections, but the incidence of virus-induced myocarditis is unknown.ObjectiveAn unbiased, blinded screening for ...
Kyle Varkoly, Kyle Varkoly, Shaoyuan Tan, Roxana Beladi, Roxana Beladi, David Fonseca, Isabela Rivabem Zanetti, Simona Kraberger, Chintan Shah, Jordan R. Yaron, Jordan R. Yaron, Liqiang Zhang, Michael Juby, Ayman Fath, Sriram Ambadapadi, Melanie House, Paul Maranian, Carl J. Pepine, Arvind Varsani, Arvind Varsani, Jan Moreb, Stacey Schultz-Cherry, Alexandra R. Lucas, Alexandra R. Lucas, Alexandra R. Lucas   +24 more
doaj   +1 more source