Results 91 to 100 of about 3,436,004 (333)
Evidence that RNA Viruses Drove Adaptive Introgression between Neanderthals and Modern Humans.
Cell, 2018 Neanderthals and modern humans interbred at least twice in the past 100,000 years. While there is evidence that most introgressed DNA segments from Neanderthals to modern humans were removed by purifying selection, less is known about the adaptive nature
D. Enard, D. Petrov
semanticscholar +1 more source
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
Construction of Stable Reporter Flaviviruses and Their Applications
Viruses, 2020 Flaviviruses are significant human pathogens that cause frequent emerging and reemerging epidemics around the world. Better molecular tools for studying, diagnosing, and treating these diseases are needed.
Coleman Baker, Pei-Yong Shi
doaj +1 more source
Rescue of a genotype 4 human hepatitis E virus from cloned cDNA and characterization of intergenotypic chimeric viruses in cultured human liver cells and in pigs [PDF]
, 2012 Hepatitis E virus (HEV) is an important but extremely understudied human pathogen. Genotypes 1 and 2 are restricted to humans, whereas genotypes 3 and 4 are zoonotic, infecting both humans and pigs.
Alicia R. Feagins +15 more
core +1 more source
Nucleic Acids Research, 2018 More than 140 post-transcriptional modifications (PTMs) are known to decorate cellular RNAs, but their incidence, identity and significance in viral RNA are still largely unknown.
W. McIntyre +10 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Extensive Diversity of RNA Viruses in Australian Ticks
Journal of Virology, 2018 Each year a growing number of individuals along the east coast of Australia experience debilitating disease following tick bites. As there is no evidence for the presence of the causative agent of Lyme disease, Borrelia burgdorferi sensu lato, in ...
Erin Harvey +7 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Emerging and Re-emerging Viral Infections in the 21st Century: Microbiological and Public Health Perspectives [PDF]
Journal of Krishna Institute of Medical Sciences University, 2021 Pathogens, especially viruses and bacteria are known to have great potential to emerge and evolve for thousands of years and it seems to be a never-ending process.
Mohan Bilikallahalli Sannathimmappa +2 more
doaj
Capturing SARS-CoV-2 from patient samples with low viral abundance: a comparative analysis
Scientific Reports, 2022 Since the beginning of the SARS-CoV-2 coronavirus pandemic, genome sequencing is essential to monitor viral mutations over time and by territory. This need for complete genetic information is further reinforced by the rapid spread of variants of concern.
Juliana Pipoli da Fonseca +6 more
doaj +1 more source