Results 211 to 220 of about 7,640,682 (253)
Myostatin/Smad3 in Spinal Muscular Atrophy: Biomarkers of Disease Severity and Treatment Response
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Given the role of Myostatin (MSTN) in muscle homeostasis and its modulation by current spinal muscular atrophy (SMA) therapies, we investigated serum MSTN and, for the first time, its downstream effector Smad3 as candidate non‐invasive biomarkers in SMA patients undergoing disease‐modifying therapies (DMTs).
Giorgia Riolo +11 more
wiley +1 more source
Discordance Between Patient and Physician Global Assessments in Early Systemic Sclerosis
Arthritis Care &Research, EarlyView.Objective This study aims to identify factors associated with patient global assessment (PtGA) and physician global assessment (PhGA) and discordance between them in systemic sclerosis (SSc). Methods Data from adults with early SSc (<5 years) from the Collaborative National Quality and Efficacy Registry were included.
Ellen Romich +35 more
wiley +1 more source
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Trends in Biochemical Sciences, 1999
A popular theory of life's origins states that the first biocatalysts were not made of protein but were made of RNA or a very similar polymer. Experiments are beginning to confirm that the catalytic abilities of RNA are compatible with this 'RNA world' hypothesis. For example, RNA can synthesize short fragments of RNA in a template-directed fashion and
D P, Bartel, P J, Unrau
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A popular theory of life's origins states that the first biocatalysts were not made of protein but were made of RNA or a very similar polymer. Experiments are beginning to confirm that the catalytic abilities of RNA are compatible with this 'RNA world' hypothesis. For example, RNA can synthesize short fragments of RNA in a template-directed fashion and
D P, Bartel, P J, Unrau
openaire +2 more sources
Current Opinion in Chemical Biology, 1999
Before large, specific peptides could be made, in an RNA world our ancestors may have used an RNA-like molecule for both catalysis and information storage. Taken together, RNA activities suggest RNA could have performed most of the essential informational functions of an ancient organism (i.e. those functions most similar to RNA's role today).
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Before large, specific peptides could be made, in an RNA world our ancestors may have used an RNA-like molecule for both catalysis and information storage. Taken together, RNA activities suggest RNA could have performed most of the essential informational functions of an ancient organism (i.e. those functions most similar to RNA's role today).
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RNA–DNA Chimeras in the Context of an RNA World Transition to an RNA/DNA World
Angewandte Chemie, 2016AbstractThe RNA world hypothesis posits that DNA and proteins were later inventions of early life, or the chemistry that gave rise to life. Most scenarios put forth for the emergence of DNA assume a clean separation of RNA and DNA polymer, and a smooth transition between RNA and DNA.
Jesse V, Gavette +3 more
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From RNA world to RNA-peptide world: A review
Theoretical and Natural Science, 2023How life starts from small molecules to RNAs and further to modern life is an unanswered question. Cyanosulfitic chemistry established the synthesis of building blocks, including 12 proteinogenic amino acids, 4 ribo- and deoxyribo-nucleosides, and phospholipids, from hydrogen cyanide and hydrogen sulfite under prebiotically plausible conditions.
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New England Journal of Medicine, 2018
RNA Biology and Parity at the Bench The 2018 Lasker–Koshland Special Achievement Award in Medical Science, announced September 11, goes to Joan A. Steitz for her pioneering discoveries in RNA biology and her work toward better representation of women and minorities in scientific research.
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RNA Biology and Parity at the Bench The 2018 Lasker–Koshland Special Achievement Award in Medical Science, announced September 11, goes to Joan A. Steitz for her pioneering discoveries in RNA biology and her work toward better representation of women and minorities in scientific research.
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Planetary and Space Science, 1995
The theory of the "RNA World" states that the first molecular systems to display the properties of self-replication and evolution were RNA molecules. The origin of life not only depended crucially upon this event, but RNA molecules can even be viewed as the first "living" things.
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The theory of the "RNA World" states that the first molecular systems to display the properties of self-replication and evolution were RNA molecules. The origin of life not only depended crucially upon this event, but RNA molecules can even be viewed as the first "living" things.
openaire +3 more sources
Science-Business eXchange, 2014
RNA-based drugs have redefined the universe of tractable targets by putting virtually anything that is gene encoded within reach of a disease-modifying agent, turning RNA into the biotech industry's de facto third drug modality.
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RNA-based drugs have redefined the universe of tractable targets by putting virtually anything that is gene encoded within reach of a disease-modifying agent, turning RNA into the biotech industry's de facto third drug modality.
openaire +1 more source