Results 271 to 280 of about 323,847 (388)

Targeting of Antithrombin in Hemophilia A or B with RNAi Therapy

open access: yesNew England Journal of Medicine, 2017
K. Pasi   +21 more
semanticscholar   +1 more source

RNAi‐mediated gene silencing of a 26S proteasome subunit increases mortality of the Japanese beetle Popillia japonica

open access: yesPest Management Science, EarlyView.
We propose the regulatory particle non‐ATPase subunit 6 of the 26S proteasome as a first good promising RNA interference target candidate to control the Japanese beetle Popillia japonica. This will help to optimize a double‐stranded RNA insecticide against this priority pest with low off‐target effects on pollinators on a gene sequence‐based prediction.
Giulia Lucetti   +10 more
wiley   +1 more source

Genome-Wide RNAi of C. elegans Using the Hypersensitive rrf-3 Strain Reveals Novel Gene Functions

open access: gold, 2003
Femke Simmer   +8 more
openalex   +2 more sources

RNA degradomics and proteomics reveal the mechanism of dsProsβ1‐mediated proteasome targeting in Psylliodes chrysocephala

open access: yesPest Management Science, EarlyView.
RNA degradomics revealed dsProsβ1‐derived siRNA‐mediated mRNA cleavage events, mainly at uracil‐guanine and adenine‐adenine pairs. Proteasome inhibition via dsProsβ1 increased mitochondrial and cytoskeletal proteins while reducing translation‐related and mRNA‐binding proteins.
Doga Cedden   +3 more
wiley   +1 more source

An epigenomic threshold hypothesis for integrating dynamic environmental signals into functional models of developmental polyphenisms

open access: yesFunctional Ecology, EarlyView.
Read the free Plain Language Summary for this article on the Journal blog. Abstract Interactions between developing embryos and a multitude of environmental factors (e.g. climate, nutrition, social cues, stress and anthropogenic contaminants) underlie adaptive and non‐adaptive developmental plasticity and carry broad implications across ecological ...
Benjamin B. Parrott, Samantha L. Bock
wiley   +1 more source

RNAi: Mammalian oocytes do it without RNA-dependent RNA polymerase

open access: bronze, 2003
Paula Stein   +3 more
openalex   +1 more source

The aging factor EPS8 induces disease-related protein aggregation through RAC signaling hyperactivation. [PDF]

open access: yesNat Aging
Koyuncu S   +6 more
europepmc   +1 more source

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