Results 271 to 280 of about 330,568 (380)

1P123 Defining fundamental steps in the assembly of Drosophila RNAi enzyme complex by TIRF microscopy(05A.Nucleic acid: Structure & Property,Poster,The 51st Annual Meeting of the Biophysical Society of Japan)

, 2013
Hiroshi Sasaki, Shintaro Iwasaki, Yuriko Sakaguchi, Tsutomu Suzuki, Hisashi Tadakuma, Yukihide Tomari   +5 more
openalex   +2 more sources

CRISPR‐Cas9 screen reveals that inhibition of enhancer of zeste homolog 2 sensitizes malignant T cells to dimethyl‐fumarate‐induced cell death

The FEBS Journal, EarlyView.
A genome‐wide CRISPR‐Cas9 screen identified H3K27 methylation as a key regulator of T‐cell lymphoma sensitivity to dimethyl fumarate (DMF). Specifically, inhibition of enhancer of zeste homolog 2 (EZH2) enhanced DMF‐induced cell death in malignant T cells. These results provide functional evidence for the role of EZH2 in modulating drug sensitivity and
Jan P. Teubner, Deniz Tümen, Arne Kandulski, Philipp Heumann, Patricia Mester, Elisabeth Aschenbrenner, Kirstin Pollinger, Manuela Gunckel, Barbara Volz, Tobias Hein, Paul L. Beltzig, Luisa Tengler, Florian Voll, Marina Kreutz, Claudia Kunst, Jan P. Nicolay, Martina Müller, Karsten Gülow   +17 more
wiley   +1 more source

Evolutionary divergence and functional insights into the heteromeric cis‐prenyltransferase of Paramecium tetraurelia

The FEBS Journal, EarlyView.
Heteromeric cis‐prenyltransferases (CPT) are indispensable for dolichol synthesis and protein N‐glycosylation in most eukaryotes. The catalytic subunits are strongly conserved throughout evolution, in contrast to the evolutionarily variable accessory subunits. The POC1 protein from Paramecium tetraurelia is the smallest identified CPT‐accessory subunit
Agnieszka Onysk, Kamil Steczkiewicz, Mariusz Radkiewicz, Paweł Link‐Lenczowski, Przemysław Surowiecki, Karolina Sztompka, Kariona A. Grabińska, Jacek K. Nowak, Liliana Surmacz   +8 more
wiley   +1 more source

Toxic effects of GAL80 and RNAi against fluorescent proteins on motor performance in <i>Drosophila</i>. [PDF]

MicroPubl Biol
Mizzi K, Grech F, Tabone S, Cacciottolo R, Cauchi RJ.   +4 more
europepmc   +1 more source

GenomeRNAi: A phenotype database for large-scale RNAi screens

, 2015
Esther Schmidt, Oliver Pelz, Svetlana Buhlmann, Hannah Fleckenstein, J. W. Mehl, Michael Boutros   +5 more
openalex   +1 more source

A virus-targeted plant receptor-like kinase promotes cell-to-cell spread of RNAi

Proceedings of the National Academy of Sciences of the United States of America, 2018
Tábata Rosas-Díaz, Dan Zhang, Pengfei Fan, Liping Wang, Xue Ding, Yuli Jiang, Tamara Jimenez-Gongora, L. Medina-Puche, Xinyan Zhao, Zhengyan Feng, Guiping Zhang, Xiaokun Liu, E. Bejarano, Li Tan, Heng Zhang, Jian‐Kang Zhu, Weiman Xing, C. Faulkner, Shingo Nagawa, Rosa Lozano-Durán   +19 more
semanticscholar   +1 more source

A guide to the types, structures, and multifaceted functions of matrix metalloproteinases in cancer

The FEBS Journal, EarlyView.
Matrix metalloproteinases (MMPs) orchestrate cancer progression and metastasis through proteolytic and non‐proteolytic actions. By remodeling the tumor microenvironment, enhancing growth factor availability, and modulating cell behavior, MMPs promote proliferation, migration or invasion, and epithelial‐to‐mesenchymal transition. Alongside extracellular
Zoi Piperigkou, Sylvia Mangani, Spyros Kremmydas, Nikolaos E. Koletsis, Nikos K. Karamanos   +4 more
wiley   +1 more source

Knockdown-Induced Fasting Phenotypes in Flatworms: Insights into Underlying Mechanisms of Feeding Behavior. [PDF]

Int J Mol Sci
Biryukov M, Dmitrieva A, Chepurnov G, Zadesenets KS.   +3 more
europepmc   +1 more source

The effect of RNA interference (RNAi) in avian metapneumovirus (AMPV) subtype A in vitro aplication

, 2007
H. N. Ferreira
openalex   +1 more source

TbTim20 facilitates protein import at a low membrane potential in trypanosomes lacking the mitochondrial genome

The FEBS Journal, EarlyView.
Protein import into mitochondria relies on TIM complexes and the membrane potential. Trypanosoma brucei has a unique TIM complex, and the role of one subunit, TbTim20, has remained unclear. Here, we show that TbTim20 is essential in cells lacking mitochondrial DNA. The importance of TbTim20 increases as the membrane potential decreases.
Corinne von Känel, Salome Aeschlimann, Michaela Husová, Silke Oeljeklaus, Philip Stettler, Achim Schnaufer, Bettina Warscheid, Alena Zíková, André Schneider   +8 more
wiley   +1 more source