Results 301 to 310 of about 2,156,375 (387)

Discovery and validation of the tumor-suppressive function of long noncoding RNA PANDA in human diffuse large B-cell lymphoma through the inactivation of MAPK/ERK signaling pathway

, 2017
Yingjun Wang, Mingzhi Zhang, Huanan Xu, Yifei Wang, Zhaoming Li, Yu Chang, Xinhuan Wang, Xiaorui Fu, Zhi‐Yuan Zhou, Siyuan Yang, Bei Wang, Yufeng Shang   +11 more
openalex   +2 more sources

Analysis of Treacher Collins syndrome 4‐associated mutations in Schizosaccharomyces pombe

FEBS Open Bio, EarlyView.
Fission yeast models carrying Treacher Collins syndrome type 4‐associated mutations reveal that impaired processivity of RNA polymerase I leads to defective rRNA transcription. This study highlights the essential role of a conserved arginine residue in Pol I elongation and provides mechanistic insight into the pathogenesis of ribosomopathies.
Kei Kawakami, Hiroaki Kato
wiley   +1 more source

The RNA-binding protein HNRNPA2B1 regulates neurite RNA abundance and motor-dependent cargo transport. [PDF]

Mol Biol Cell
Lo J, Gifford LB, Vaeth KF, Baldwin A, Bhardwaj G, Goo CEA, Mukherjee N, Russ HA, Moore JK, Taliaferro JM.   +9 more
europepmc   +1 more source

Activity-assembled nBAF complex mediates rapid immediate early gene transcription by regulating RNA polymerase II productive elongation

Karen G. Cornejo, Andie Venegas, Morgan H. Sono, Madeline Door, Brenda Gutierrez-Ruiz, Lucy B. Karabedian, Supratik G. Nandi, Marco Hadisurya, W. Andy Tao, Emily C. Dykhuizen, Ramendra N. Saha   +10 more
openalex   +1 more source

Establishment of a coculture system for Porphyromonas gingivalis and head and neck squamous cell carcinoma using spheroid culture and LATS inhibition

FEBS Open Bio, EarlyView.
We established a spheroid coculture system enabling viable Porphyromonas gingivalis–HNSCC interactions under normoxic conditions. Inhibition of LATS1/2 maintains tumor cells in an undifferentiated state, which may promote spheroid growth and create a more permissive environment for bacterial persistence.
Yurika Nakajima, Shogo Okazaki, Muneaki Tamura, Shuichi Sato, Kenichi Imai   +4 more
wiley   +1 more source

IRESeek: structure-informed deep learning method for accurate identification of internal ribosome entry sites in circular RNAs. [PDF]

NAR Genom Bioinform
Zhang F, Zhu H, Gao J, Hu J, Chen K, Zhou SK, Xiong P.   +6 more
europepmc   +1 more source

DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling

FEBS Open Bio, EarlyView.
Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang, Jing Wang, De‐Hui Qian, Yang‐Fan Lv, Tian‐Le Cheng, Da‐Peng Wang, Jing Zhang, Ye Fan   +7 more
wiley   +1 more source

CircRM: profiling circular RNA modifications from nanopore direct RNA sequencing. [PDF]

Brief Bioinform
Li J, Chen S, Wu Z, Wang H, Xia R, Meng J, Zhang Y.   +6 more
europepmc   +1 more source

Directional Phosphorylation and Nuclear Transport of the Splicing Factor SRSF1 Is Regulated by an RNA Recognition Motif

, 2016
Pedro Serrano, Brandon E. Aubol, Malik M. Keshwani, Stefano Forli, Chen-Ting Ma, Samit Dutta, M. Geralt, Kurt Wüthrich, Joseph A. Adams   +8 more
openalex   +2 more sources

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source