Results 111 to 120 of about 476,060 (306)
Recent Applications of Mesoporous Silica Nanoparticles in Gene Therapy
Advanced Healthcare Materials, EarlyView.The review summarizes the synthesis of mesoporous silica nanoparticles (MSNs) with modifiable surface properties, functionalization strategies, mechanism of therapeutic payload release, and current applications in gene therapy, focusing on their capabilities in the targeted delivery of therapeutic nucleic acids, CRISPR‐Cas systems, and other genetic ...
Tamanna Binte Huq +4 more
wiley +1 more source
Clumsy packings of graphs [PDF]
arXiv, 2018 Let $G$ and $H$ be graphs. We say that $P$ is an $H$-packing of $G$ if $P$ is a set of edge-disjoint copies of $H$ in $G$. An $H$-packing $P$ is maximal if there is no other $H$-packing of $G$ that properly contains $P$. Packings of maximum cardinality have been studied intensively, with several recent breakthrough results.
arxiv
Inhibition by RNA of RNase H Activity Associated with Reverse Transcriptase in Rauscher Murine Leukemia Virus Cores [PDF]
, 1978 M. G. Sarngadharan +2 more
openalex +1 more source
Advanced Healthcare Materials, EarlyView.A flexible electrode loaded with a carbon nanowire network (CC@C‐NWN) is developed for electrochemically generating reactive chlorine species (RCS) from abundant chloride ions in body fluids for tumor therapy. CC@C‐NWN enhances chlorine evolution, inducing redox dysregulation and synergistic apoptosis‐ferroptosis in tumor cells.
Cuinan Jiang +10 more
wiley +1 more source
In Vitro Transcription of 70 S RNA by the RNA-Directed DNA Polymerase of Rous Sarcoma Virus: Lack of Influence of RNase H [PDF]
, 1976 Marc S. Collett, Anthony J. Faras
openalex +1 more source
Advanced Healthcare Materials, EarlyView.Through tuning biomimetic scaffold stiffness and matrix composition the reparative capacity of astrocyte progenitors is enhanced. Soft, collagen‐IV/fibronectin‐functionalized scaffolds promote progenitor growth while improving angiogenic, immunomodulatory, and neurotrophic capacity in a stiffness and matrix‐dependent manner, demonstrating the impact of
Cian O'Connor +10 more
wiley +1 more source
Synthetic lethal mutants in Escherichia coli define pathways necessary for survival with RNase H deficiency. [PDF]
J Bacteriol, 2023 Das S, Forrest J, Kuzminov A.
europepmc +1 more source
Advanced Healthcare Materials, EarlyView.Hybrid NPs are developed as efficient, scalable nanocarriers for in vitro microRNA delivery, ensuring high loading efficiency, controlled release, physiological and long‐term storage stability. They outperform commercial lipid‐based reagents in terms of transfection efficiency and biocompatibility.
Letizia Nicoletti +11 more
wiley +1 more source
Polynomial maps with nilpotent Jacobians in dimension three I [PDF]
arXiv, 2017 In this paper, we first prove that $u,v,h$ are linearly dependent over ${\bf K}$ if $JH$ is nilpotent and $H$ has the form: $H=(u(x,y,z),v(u,h),h(x,y))$ with $H(0)=0$ or $H=(u(x,y),v(u,h),h(x,y,z))$ with $H(0)=0$. Then we classify polynomial maps of the form $H=(u(x,y),v(x,y,z), h(x,y))$ in the case that $JH$ is nilpotent and $(\deg_yu,\deg_yh)\leq 2$.
arxiv
RNase H enables efficient repair of R-loop induced DNA damage
eLife, 2016 R-loops, three-stranded structures that form when transcripts hybridize to chromosomal DNA, are potent agents of genome instability. This instability has been explained by the ability of R-loops to induce DNA damage. Here, we show that persistent R-loops
Jeremy D Amon, Douglas Koshland
doaj +1 more source