Advanced Science, EarlyView.Sympathetic nerve innervation promotes the progression of Epstein‐Barr virus‐positive diffuse large B‐cell lymphoma (EBV+ DLBCL) via β2‐adrenergic receptors. The discovery of enhanced nerve infiltration and β2AR expression reveals a novel mechanism and highlights the sympathetic–β2AR axis as a promising target for therapeutic intervention in EBV+ DLBCL.
Silan Huang +10 more
wiley +1 more source
Characterization of Escherichia coli RNase H Discrimination of DNA Phosphorothioate Stereoisomers. [PDF]
Nucleic Acid Ther, 2021 Kiełpiński ŁJ +3 more
europepmc +1 more source
Molecular cloning of a ribonuclease H (RNase HI) gene from an extreme thermophileThermus thermophilusHB8: a thermostable RNase H can functionally replace theEscherichia colienzymein vivo [PDF]
, 1991 Mitsuhiro Itaya, Kanae Kondo
openalex +1 more source
piR‐RCC Suppresses Renal Cell Carcinoma Progression by Facilitating YBX‐1 Cytoplasm Localization
Advanced Science, EarlyView.PIWI‐interacting RNAs (piRNAs), a novel category of small non‐coding RNAs, have been implicated in the development of various diseases. This study explores the tumor‐suppressive mechanism of a downregulated piRNA (designated piR‐RCC) in renal cell carcinoma (RCC), and provides a delivery strategy targeting RCC tumor by constructing a cell membrane ...
Ruyue Wang +16 more
wiley +1 more source
Expression of thermostable MMLV reverse transcriptase in Escherichia coli by directed mutation
AMB ExpressThe functionality of Moloney murine leukemia virus reverse transcriptase (MMLV RT) will increase with the improvement of its solubility and thermal stability.
Marzieh Divbandi +4 more
doaj +1 more source
Structural and functional investigation of the human snRNP assembly factor AAR2 in complex with the RNase H-like domain of PRPF8. [PDF]
Acta Crystallogr D Struct Biol, 2022 Preussner M +6 more
europepmc +1 more source
Defects in Moloney murine leukemia virus replication caused by a reverse transcriptase mutation modeled on the structure of Escherichia coli RNase H [PDF]
, 1992 Alice Telesnitsky +2 more
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Listerin Alleviates Alzheimer's Disease through IRE1‐mediated Decay of TLR4 mRNA
Advanced Science, EarlyView.Alzheimer's disease (AD) progression is influenced by microglia‐mediated neuroinflammation. Here, it is demonstrated that Listerin suppresses neuroinflammatory signaling and cognitive impairment in AD models by triggering IRE1α‐mediated TLR4 mRNA decay. Adenoviral Listerin delivery reduces amyloid‐β pathology, positioning it as a new therapeutic target.
Fei Qin +9 more
wiley +1 more source
RNase H is an exo- and endoribonuclease with asymmetric directionality, depending on the binding mode to the structural variants of RNA:DNA hybrids. [PDF]
Nucleic Acids Res, 2022 Lee H +6 more
europepmc +1 more source
Eukaryotic RNAse H shares a conserved domain with caulimovirus proteins that facilitate translation of polycistronic RNA [PDF]
, 1994 Arcady Mushegian +2 more
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