Results 231 to 240 of about 476,060 (306)

Madurahydroxylactone Derivatives as Dual Inhibitors of Human Immunodeficiency Virus Type 1 Integrase and RNase H [PDF]

, 2007
Christophe Marchand, John A. Beutler, Antony Wamiru, Scott R. Budihas, Ute Möllmann, Lothar Heinisch, John W. Mellors, S F Le Grice, Yves Pommier   +8 more
openalex   +1 more source

Multi‐Omics and ‐Organ Insights into Energy Metabolic Adaptations in Early Sepsis Onset

Advanced Science, EarlyView.
This study shows that patients at risk of sepsis have a distinct metabolite and lipid signature, including serine and aminoadipic acid, in their serum before clinical diagnosis. A mouse model of sepsis with a compatible serum signature reveals underlying metabolic changes, including mitochondrial adaptation, altered serine‐dependent purine metabolism ...
Lin‐Lin Xu, Zhengyuan Zhou, Sascha Schäuble, Wolfgang Vivas, Karen Dlubatz, Michael Bauer, Sebastian Weis, Mervyn Singer, Roman Lukaszewski, Gianni Panagiotou   +9 more
wiley   +1 more source

RNase H activity: Structure, specificity, and function in reverse transcription [PDF]

, 2008
Sharon J. Schultz, James J. Champoux
openalex   +1 more source

Multiscale Organization of Neural Networks in a 3D Bioprinted Matrix

Advanced Science, EarlyView.
A 3D bioprint model of primary neurons has been engineered with a millimeter‐scale functional neural network, and it recapitulates in vivo transcriptomic features under both normal and disease conditions to the greatest extent. The successful integration of mature neurons and 3D bioprinting signifies a major advance in neuroscience modeling ...
Huiyu Yang, Jiangang Zhang, Yiran Li, Zihan Zhong, Wenhua Li, Haojun Luo, Yanyong Liu, Liujian Ouyang, Zhuoran Jiang, Yuning Sun, Hang Sun, Lulu Liu, Huayu Yang, Yu Wang, Nan Yang, Wenbin Ma, Yilei Mao   +16 more
wiley   +1 more source

Synthesis, biophysical properties, and RNase H activity of 6'-difluoro[4.3.0]bicyclo-DNA. [PDF]

Beilstein J Org Chem, 2019
Frei S, Katolik AK, Leumann CJ.
europepmc   +1 more source

Mutations of the RNase H C Helix of the Moloney Murine Leukemia Virus Reverse Transcriptase Reveal Defects in Polypurine Tract Recognition

, 2002
David Lim, Marianna Orlova, Stephen P. Goff   +2 more
openalex   +1 more source

O‐GalNAc Glycosylation Activates MBL‐Mediated Complement and Coagulation Cascades to Drive Organotropic Metastasis

Advanced Science, EarlyView.
Upregulated glycosyltransferase GALNT9 in neuroendocrine (NE) carcinomas increases O‐GalNAc glycosylation on cell membrane proteins, particularly Annexin‐A2 (ANXA2). Elevated O‐GalNAc glycan induces the binding of NE cancer cells to mannose binding lectin 2 (MBL2), activating the MBL‐MBL associated serine protease (MBL‐MASP) complement pathway in the ...
Xinyu Chen, Wei Bao, Kaiyuan Liu, Na Jing, Genyu Du, Luyao Jiang, Qian You, Yingchao Zhang, Penghui Xu, Chaping Cheng, Nan Wang, Xialian Xi, Mingyue Wang, Yiyun Liu, Jinming Wang, Huifang Zhao, Shilei Zhang, Dinglan Wu, Chi‐Fai Ng, Jiahua Pan, Wei Xue, Wei‐Qiang Gao, Pengcheng Zhang, Kai Zhang, Helen He Zhu   +24 more
wiley   +1 more source

3-Hydroxypyrimidine-2, 4-dione Derivatives as HIV Reverse Transcriptase-Associated RNase H Inhibitors: QSAR Analysis and Molecular Docking Studies. [PDF]

Iran J Pharm Res, 2020
Mostoufi A, Chamkouri N, Kordrostami S, Alghasibabaahmadi E, Mojaddami A.   +4 more
europepmc   +1 more source

Dynamic NMR Structures of [Rp]- and [Sp]-Phosphorothioated DNA-RNA Hybrids: Is Flexibility Required for RNase H Recognition?

, 2003
Marco Tonelli, Nikolai B. Ulyanov, Todd M. Billeci, Bolesław T. Karwowski, Piotr Guga, Wojciech J. Stec, Thomas Leroy James   +6 more
openalex   +1 more source

KRAS mRNA Spleen‐Targeting Lipid Nanoparticles Synergize with Irinotecan Silicasomes to Robustly Augment the Cancer Immunity Cycle in Pancreatic Cancer

Advanced Science, EarlyView.
To overcome pancreatic cancer's immunosuppressive barriers, this study explores a dual approach: triggering immunogenic tumor cell death at the primary tumor site with irinotecan‐loaded silicasomes and enhancing immune activation in the spleen using LNPs encapsulating tumor antigen mRNA and a TLR7/8 agonist.
Lijia Luo, Xiang Wang, Yu‐Pei Liao, Andre E. Nel   +3 more
wiley   +1 more source