Results 271 to 280 of about 476,060 (306)

Reuse of cDNA microarrays hybridized with cRNA by stripping with RNase H

, 2008
Haoxiang Wu, James A. Bynum, Salomon Stavchansky, Phillip D. Bowman   +3 more
openalex   +1 more source

A Combined Aptamer Pulldown‐DNAzyme Cleavage Assay for Intact Methicillin Resistant Staphylococcus aureus Cells

Angewandte Chemie International Edition, Accepted Article.
Accurate and convenient detection of methicillin resistant Staphylococcus aureus (MRSA) plays a vital role in determining appropriate antibiotic interventions. Herein, we report the first example combining a DNA aptamer and an RNA‐cleaving DNAzyme (RCD) that bind different protein markers for selective preconcentration and detection of MRSA. An aptamer
Monsur Ali, Abigail Almeida, Dawn White, Alfredo Capretta, John David Brennan   +4 more
wiley   +1 more source

Chromosome‐scale reference genome of Pectocarya recurvata, the species with the smallest reported genome size in Boraginaceae

Applications in Plant Sciences, EarlyView.
Abstract Premise Pectocarya recurvata (Boraginaceae, subfamily Cynoglossoideae), a species native to the Sonoran Desert (North America), has served as a model system for a suite of ecological and evolutionary studies. However, no reference genomes are currently available in Cynoglossoideae. A high‐quality reference genome for P.
Poppy C. Northing, Jessie A. Pelosi, D. Lawrence Venable, Katrina M. Dlugosch   +3 more
wiley   +1 more source

The Stem Cell Transcription Factor OCT4 Silences Target DNA Methyltransferase 1 to Strengthen DNA Damage Response in Cisplatin‐Treated Gastric Cancer Cells

Biotechnology and Applied Biochemistry, EarlyView.
ABSTRACT OCT4 plays a crucial role in the DNA damage response(DDR) mechanism, whereas cisplatin (CDDP) acts as an anti‐tumor agent by inducing DDR. This study aimed to investigate the role of OCT4 in regulating DNA methyltransferase 1 (DNMT1) in CDDP‐treated gastric cancer (GC).
Zhengzheng Yan, Xiaoqian Bu, Haixia Chen, Chongren Ren, Ji Li, Yongjie Wu, Jun Xing   +6 more
wiley   +1 more source

Dynamic Compression Improves Chondrogenesis in the Tissue Engineered Model of Cartilage

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Hyaline cartilage is a dense avascular tissue with low regenerative potential, present at the ends of the diarthrodial joints and in the cartilage growth plate. Skeletal diseases often result from extracellular changes in this tissue; however, studies of these are hindered by the tissue complexity, the difficulty in obtaining human material ...
Marc V. Farcasanu, Thais de las Heras Ruiz, Francesca M. Johnson de Sousa Brito, Jamie Soul, Jonathan Coxhead, Matthew J. German, David A. Young, Ana M. Ferreira‐Duarte, Katarzyna A. Piróg   +8 more
wiley   +1 more source

Balancing Doses of EL222 and Light Improves Optogenetic Induction of Protein Production in Komagataella phaffii

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Komagataella phaffii, also known as Pichia pastoris, is a powerful host for recombinant protein production, in part due to its exceptionally strong and tightly controlled PAOX1 promoter. Most K. phaffii bioprocesses for recombinant protein production rely on PAOX1 to achieve dynamic control in two‐phase processes.
Shannon M. Hoffman, Sebastián Espinel‐Ríos, Sarah K. Kwartler, Makoto A. Lalwani, José L. Avalos   +4 more
wiley   +1 more source

Integration of Single Pass Tangential Flow Filtration and High Performance Countercurrent Membrane Purification for Intensification of Monoclonal Antibody Processing

Biotechnology and Bioengineering, EarlyView.
ABSTRACT There is increasing interest in the development of intensified processes that can provide significant reductions in manufacturing costs for monoclonal antibody (mAb) products. This study examines the performance of an integrated membrane process that combines single‐pass tangential flow filtration (SPTFF) with high‐performance countercurrent ...
Mirko Minervini, Aylin Mohammadzadehmarandi, Ali Behboudi, Sheldon F. Oppenheim, Andrew L. Zydney   +4 more
wiley   +1 more source

The contribution of extracellular RNA and its derived biomaterials in disease management

BMEMat, EarlyView.
The implications of exRNA's biological function and the structural uniqueness of RNA help establish a close connection between RNA, material, and modern medicine. Abstract The RNA found in the circular system is known as extracellular RNA (exRNA). This kind of RNA has been found to play a biological role similar to that of a messenger. They can be used
Yu Wei, Zhangyi Wang, Zixuan Qin, Qianqian Wan, Yutao Li, Franklin R. Tay, Chenyu Wang, Tong Zhang, Lina Niu   +8 more
wiley   +1 more source

Unveiling the complexity of cellular senescence in cancers: From mechanism to therapeutic opportunities

BMEMat, EarlyView.
This review highlights the complex roles of cellular senescence in cancer progression and suppression, discusses the mechanisms and regulatory pathways involved, and evaluates the efficacy of the “One‐Two punch” sequential treatment approach while addressing emerging challenges in this novel therapeutic strategy.
Qiuming Pan, Ye Zhu, Zhi Ye, Huayang Zhang, Junxi Wang, Guozhong Yi, Zhiyong Li, Rongyang Xu, Luyao Wang, Zhenzhen Wu, Songtao Qi, Guanglong Huang, Shanqiang Qu   +12 more
wiley   +1 more source

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Molecular diversities of RNases H

Journal of Bioscience and Bioengineering, 1999
RNase H is an enzyme that specifically cleaves RNA hybridized to DNA. The enzyme is ubiquitously present in various organisms. Single bacterial and eucaryotic cells often contain two RNases H, whereas single archaeal cells contain only one. To determine whether there is a physiological significance in the ubiquity and multiplicity of the enzyme, and ...
Masaaki Morikawa, Shigenori Kanaya, Mitsuru Haruki, Naoto Ohtani   +3 more
openaire   +3 more sources