Results 271 to 280 of about 14,336,830 (357)

Synthesis, biophysical properties, and RNase H activity of 6'-difluoro[4.3.0]bicyclo-DNA. [PDF]

Beilstein J Org Chem, 2019
Frei S, Katolik AK, Leumann CJ.
europepmc   +1 more source

Mutations of the RNase H C Helix of the Moloney Murine Leukemia Virus Reverse Transcriptase Reveal Defects in Polypurine Tract Recognition

, 2002
David Lim, Marianna Orlova, Stephen P. Goff   +2 more
openalex   +1 more source

Inhibition of RNase to Attenuate Fungal‐Manipulated Rhizosphere Microbiome and Diseases

Advanced Science, EarlyView.
Fusarium graminearum uses its virulence effector Fg12, a fungal RNase, to manipulate the host rhizosphere microbiome and promote infection. Guanosine monophosphate (GMP) blocks Fg12's RNase activity. This reveals a key pathogen‐microbiota interaction mechanism and proposes GMP as a targeted strategy to disarm this core fungal effector, offering a ...
Bo Yang, Sen Yang, Xiaomi Wang, Yuanwei Zhang, Yao Zhao, Menghuan Tao, Jinyi Zhu, Wanxin Zhang, Yansu Wang, Kaixuan Duan, Yan Wang, Wenwu Ye, Zhenfei Guo, Yuanchao Wang   +13 more
wiley   +1 more source

3-Hydroxypyrimidine-2, 4-dione Derivatives as HIV Reverse Transcriptase-Associated RNase H Inhibitors: QSAR Analysis and Molecular Docking Studies. [PDF]

Iran J Pharm Res, 2020
Mostoufi A, Chamkouri N, Kordrostami S, Alghasibabaahmadi E, Mojaddami A.   +4 more
europepmc   +1 more source

Expression of RNase H of human hepatitis B virus polymerase inEscherichia coli

, 2003
Hong Cheng, Huizhong Zhang, Wan-An Shen, Yanfang Liu, MA Fu-cheng   +4 more
openalex   +1 more source

Splicing Shift of RAC1 Accelerates Tumorigenesis and Defines a Potent Therapeutic Target in Lung Cancer

Advanced Science, EarlyView.
Dysregulated RNA splicing is an underappreciated molecular feature of cancer. By integrating murine and cellular models with patient specimens of lung adenocarcinoma, this study demonstrates that RAC1B, rather than RAC1A isoform, promotes tumorigenesis and presents a potent therapeutic target for lung cancer. Mechanistically, RAC1B preferentially binds
Yueren Yan, Ning Wang, Bowen Xing, Min Yang, Jun Shang, Yufang Bao, Lixing Xiao, Ningxia Zhang, Yunpeng Ren, Chunnan Liu, Yuting Chen, Han Han, Yunjian Pan, Lei Lv, Wei‐Xing Zong, Hongbin Ji, Changyou Zhan, Zefeng Wang, Haiquan Chen, Yongbo Wang   +19 more
wiley   +1 more source

Elevated Genome-Wide Instability in Yeast Mutants Lacking RNase H Activity

Genetics, 2015
K. O'Connell, S. Jinks-Robertson, T. Petes   +2 more
semanticscholar   +1 more source

Dynamic NMR Structures of [Rp]- and [Sp]-Phosphorothioated DNA-RNA Hybrids: Is Flexibility Required for RNase H Recognition?

, 2003
Marco Tonelli, Nikolai B. Ulyanov, Todd M. Billeci, Bolesław T. Karwowski, Piotr Guga, Wojciech J. Stec, Thomas Leroy James   +6 more
openalex   +1 more source

A new vector and RNase H method for the subtractive hybridization

Nucleic Acids Research, 1989
Kogo Kuze, Akira Shimizu, Tasuku Honjo
openaire   +4 more sources

A Machine‐Learning Approach Identifies Rejuvenating Interventions in the Human Brain

Advanced Science, EarlyView.
Rising life expectancy increases the incidence of age‐related neurodegeneration. Reverting brain aging through effective rejuvenation strategies constitutes a promising strategy to counteract these disorders and restore brain function. This study uses a brain‐specific transcriptional aging clock to screen over 43 000 perturbation profiles, identifying ...
Guillem Santamaria, Cristina Iglesias, Sascha Jung, Javier Arcos Hodar, Ruben Nogueiras, Antonio del Sol   +5 more
wiley   +1 more source