Mechanisms of HIV-1 Nucleocapsid Protein Inhibition by Lysyl-Peptidyl-Anthraquinone Conjugates [PDF]
, 2016 The Nucleocapsid protein NCp7 (NC) is a nucleic acid chaperone responsible for essential steps of the HIV-1 life cycle and an attractive candidate for drug development.
Alice Sosic +12 more
core +2 more sources
Effect of native gastric mucus on in vivo hybridization therapies directed at Helicobacter pylori [PDF]
, 2015 Helicobacter pylori infects more than 50% of the worldwide population. It is mostly found deep in the gastric mucus lining of the stomach, being a major cause of peptic ulcers and gastric adenocarcinoma. To face the increasing resistance of H.
Azevedo, Nuno F +13 more
core +8 more sources
Chemical evolution of an autonomous DNAzyme with allele-specific gene silencing activity
Nature Communications, 2023 Low activity has been the primary obstacle impeding the use of DNA enzymes (DNAzymes) as gene silencing agents in clinical applications. Here we describe the chemical evolution of a DNAzyme with strong catalytic activity under near physiological ...
Kim Nguyen +2 more
doaj +1 more source
Hfq binding changes the structure of Escherichia coli small noncoding RNAs OxyS and RprA, which are involved in the riboregulation of rpoS [PDF]
, 2013 OxyS and RprA are two small noncoding RNAs (sRNAs) that modulate the expression of rpoS, encoding an alternative sigma factor that activates transcription of multiple Escherichia coli stress-response genes. While RprA activates rpoS for translation, OxyS
Callaghan, Anastasia +9 more
core +1 more source
The metabolism of aged seeds. The ribonucleolytic activity of rye grain embryos of different ages
Acta Societatis Botanicorum Poloniae, 2014 Winter rye grain, harvested in various years and exhibiting clearly differing viability. was studied. Higher total ribonucleolytic activity was found in the post-ribosomal supernatant than in the ribosomes themselves.
Kazimierz Zalewski
doaj +1 more source
RNA-binding protein immunoprecipitation as a tool to investigate plant miRNA processing interference by regulatory proteins of diverse origin [PDF]
, 2018 Background: Due to the nature of viral RNA genomes, RNA viruses depend on many RNA-binding proteins (RBP) of viral and host origin for replication, dissemination and evasion of host RNA degradation pathways.
Garcia, Maria Laura +2 more
core +2 more sources
Inorganic Chemistry, 2021 The structure, stability, and enzymatic activity of the adduct formed upon the reaction of the V–picolinato (pic) complex [VIVO(pic)2(H2O)], with an octahedral geometry and the water ligand in cis to the V=O group, with the bovine pancreatic ribonuclease
G. Ferraro +7 more
semanticscholar +1 more source
Revista do Instituto de Medicina Tropical de São Paulo, 1995 Leishmania braziliensis is a causative agent of American Cutaneous Leishmaniasis (ACL). The 034-JCG strain, isolated from a patient from the northern region of Paraná State, Brazil, was cultivated in Blood Agar Base medium, lyophilized and submitted to ...
T. G. V. Silveira, C Kemmelmeier
doaj +1 more source
Atypical protein disulfide isomerases (PDI): Comparison of the molecular and catalytic properties of poplar PDI-A and PDI-M with PDI-L1A. [PDF]
PLoS ONE, 2017 Protein disulfide isomerases are overwhelmingly multi-modular redox catalysts able to perform the formation, reduction or isomerisation of disulfide bonds. We present here the biochemical characterization of three different poplar PDI isoforms.
Benjamin Selles +4 more
doaj +1 more source
Circulating microRNAs -The potential biomarkers for early diagnosis of osteoarthritis
Tạp chí Khoa học Đại học Mở Thành phố Hồ Chí Minh - Kỹ thuật và Công nghệ, 2020 Osteoarthritis (OA) is the most common form of arthritis and is one of the main causes of joint pain, impaired mobility and physical disability. Early diagnosis of OA is an important factor for effective treatment. However, current diagnostic methods are
Hồ Thị Bích Phương +2 more
doaj +1 more source