RNA-binding proteins and exoribonucleases modulating miRNA in cancer: the enemy within [PDF]
Experimental and Molecular MedicineRecent progress in the investigation of microRNA (miRNA) biogenesis and the miRNA processing machinery has revealed previously unknown roles of posttranscriptional regulation in gene expression.
Yoona Seo, Jiho Rhim, Jong Heon Kim
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Localization of components of the RNA-degrading machine in Bacillus subtilis [PDF]
Frontiers in Microbiology, 2016 In bacteria, the control of mRNA stability is crucial to allow rapid adaptation to changing conditions. In most bacteria, RNA degradation is catalyzed by the RNA degradosome, a protein complex composed of endo- and exoribonucleases, RNA helicases and ...
Nora Cascante-Estepa +2 more
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Regulation of co-translational mRNA decay by PAP and DXO1 in Arabidopsis [PDF]
BMC Plant BiologyBackground mRNA decay is central in the regulation of mRNA homeostasis in the cell. The recent discovery of a co-translational mRNA decay pathway (also called CTRD) has changed our understanding of the mRNA decay process.
Marie-Christine Carpentier +3 more
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How hydrolytic exoribonucleases impact human disease: Two sides of the same story [PDF]
FEBS Open Bio, 2023 RNAs are extremely important molecules inside the cell, which perform many different functions. For example, messenger RNAs, transfer RNAs and ribosomal RNAs are involved in protein synthesis, whereas noncoding RNAs have numerous regulatory roles ...
Susana M. Costa +4 more
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Nuclease Activity of the Junín Virus Nucleoprotein C-Terminal Domain [PDF]
Viruses, 2023 The mammarenavirus Junín (JUNV) is the causative agent of Argentine hemorrhagic fever, a severe disease of public health concern. The most abundant viral protein is the nucleoprotein (NP), a multifunctional, two-domain protein with the primary role as ...
Alicia Armella Sierra +6 more
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Tick-borne flavivirus exoribonuclease-resistant RNAs contain a double loop structure [PDF]
Nature CommunicationsViruses from the Flaviviridae family contain human relevant pathogens that generate subgenomic noncoding RNAs during infection using structured exoribonuclease resistant RNAs (xrRNAs).
Conner J. Langeberg +4 more
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Identification of a novel deFADding activity in human, yeast and bacterial 5′ to 3′ exoribonucleases [PDF]
Nucleic Acids Research, 2022 Sunny Sharma, Jun Yang, Liang Tong
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Conserved domains and structural motifs that differentiate closely related Rex1 and Rex3 DEDDh exoribonucleases are required for their function in yeast [PDF]
PLoS ONEPeter W. Daniels +3 more
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Structural characterization of NrnC identifies unifying features of dinucleases
eLife, 2021 RNA degradation is fundamental for cellular homeostasis. The process is carried out by various classes of endolytic and exolytic enzymes that together degrade an RNA polymer to mono-ribonucleotides.
Justin D Lormand +8 more
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Regulation of miRNA content. Part 2. Degradation of miRNAs
Zdorovʹe Rebenka, 2021 The scientific review presents the process of regulation of microRNA content — microRNA degradation. To write the article, information was searched using databases Scopus, Web of Science, MedLine, PubMed, Google Scholar, EMBASE, Global Health, The ...
A.E. Abaturov, V.L. Babуch
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