RNA-binding proteins and exoribonucleases modulating miRNA in cancer: the enemy within [PDF]
Experimental and Molecular MedicineRecent progress in the investigation of microRNA (miRNA) biogenesis and the miRNA processing machinery has revealed previously unknown roles of posttranscriptional regulation in gene expression.
Yoona Seo, Jong Heon Kim
exaly +3 more sources
Distinct modes of RNA degradation by the structurally related coronavirus and arenavirus exoribonucleases [PDF]
Journal of VirologyCoronaviruses and arenaviruses encode evolutionarily related DEDDh-family 3′–5′ exoribonuclease (ExoN) domains, which support the replication of their RNA genomes and evasion of the host’s antiviral immunity.
Patricia C. Hernandez +2 more
doaj +2 more sources
Regulation of co-translational mRNA decay by PAP and DXO1 in Arabidopsis [PDF]
BMC Plant BiologyBackground mRNA decay is central in the regulation of mRNA homeostasis in the cell. The recent discovery of a co-translational mRNA decay pathway (also called CTRD) has changed our understanding of the mRNA decay process.
Marie-Christine Carpentier +3 more
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A structural bridge between dengue virus tandem xrRNAs facilitates coordination of exonuclease resistance [PDF]
mBioOrthoflavivirus RNA genomes resist host 5′–3′ exoribonucleases to produce subgenomic flaviviral RNAs (sfRNAs). This resistance is conferred by exoribonuclease-resistant RNA (xrRNA) structures within the viral 3′ untranslated region that often occur in ...
Elizabeth Spear +5 more
doaj +2 more sources
Conserved domains and structural motifs that differentiate closely related Rex1 and Rex3 DEDDh exoribonucleases are required for their function in yeast. [PDF]
PLoS ONEThe DEDD family of exonucleases has expanded through evolution whilst retaining a conserved catalytic domain. One subgroup with closely related catalytic DEDD domain sequences includes the yeast enzymes Rex1 (RNA exonuclease 1) and Rex3, the metazoan ...
Peter W Daniels +3 more
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Tick-borne flavivirus exoribonuclease-resistant RNAs contain a double loop structure [PDF]
Nature CommunicationsViruses from the Flaviviridae family contain human relevant pathogens that generate subgenomic noncoding RNAs during infection using structured exoribonuclease resistant RNAs (xrRNAs).
Conner J. Langeberg +4 more
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Structural characterization of NrnC identifies unifying features of dinucleases
eLife, 2021 RNA degradation is fundamental for cellular homeostasis. The process is carried out by various classes of endolytic and exolytic enzymes that together degrade an RNA polymer to mono-ribonucleotides.
Justin D Lormand +8 more
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Regulation of miRNA content. Part 2. Degradation of miRNAs
Zdorovʹe Rebenka, 2021 The scientific review presents the process of regulation of microRNA content — microRNA degradation. To write the article, information was searched using databases Scopus, Web of Science, MedLine, PubMed, Google Scholar, EMBASE, Global Health, The ...
A.E. Abaturov, V.L. Babуch
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Cap-Independent Circular mRNA Translation Efficiency
Vaccines, 2023 Recently, the mRNA platform has become the method of choice in vaccine development to find new ways to fight infectious diseases. However, this approach has shortcomings, namely that mRNA vaccines require special storage conditions, which makes them less
Andrei A. Deviatkin +9 more
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Nature Communications, 2020 Bacterial RNA degradation is typically initiated by endoribonucleases and followed by exoribonucleases. Here the authors report the targetome of endoRNase Y in Streptococcus pyogenes, revealing the interplay between RNase Y and 3′-to-5′ exoribonuclease ...
Laura Broglia +6 more
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