Results 11 to 20 of about 3,495 (190)
How hydrolytic exoribonucleases impact human disease: Two sides of the same story [PDF]
FEBS Open Bio, 2023 RNAs are extremely important molecules inside the cell, which perform many different functions. For example, messenger RNAs, transfer RNAs and ribosomal RNAs are involved in protein synthesis, whereas noncoding RNAs have numerous regulatory roles ...
Susana M. Costa +4 more
doaj +2 more sources
Global Characterization of XRN 5′-3′ Exoribonucleases and Their Responses to Environmental Stresses in Plants [PDF]
Diversity, 2021 The XRN family of 5′-3′ Exoribonucleases is functionally conserved in eukaryotic organisms. However, the molecular evolution of XRN proteins in plants and their functions in plant response to environment stresses remain largely unexplored. In this study,
Weimeng Song +5 more
doaj +2 more sources
A dedicated diribonuclease resolves a key bottleneck for the terminal step of RNA degradation [PDF]
eLife, 2019 Degradation of RNA polymers, an ubiquitous process in all cells, is catalyzed by specific subsets of endo- and exoribonucleases that together recycle RNA fragments into nucleotide monophosphate.
Soo-Kyoung Kim +8 more
doaj +2 more sources
The human exosome: an autoantigenic complex of exoribonucleases in myositis and scleroderma [PDF]
Arthritis Research & Therapy, 2000 The anti-PM/Scl autoantibodies are known to characterize a subset of autoimmune patients with myositis, scleroderma (Scl), and the PM/Scl overlap syndrome. The major autoantigens that are recognized by anti-PM/Scl autoantibodies are designated PM/Scl-100 and PM/Scl-75.
Brouwer, R. +2 more
openaire +6 more sources
Real-time fluorescence detection of exoribonucleases [PDF]
RNA, 2009 The identification of RNases or RNase effectors is a continuous challenge, particularly given the current importance of RNAs in the control of genome expression. Here, we show that a fluorogenic RNA–DNA hybrid is a powerful tool for a real-time fluorescence detection and assay of exoribonucleases (RT-FeDEx).
Sinturel, F. +5 more
core +7 more sources
Exoribonuclease superfamilies: structural analysis and phylogenetic distribution [PDF]
Nucleic Acids Research, 2001 Exoribonucleases play an important role in all aspects of RNA metabolism. Biochemical and genetic analyses in recent years have identified many new RNases and it is now clear that a single cell can contain multiple enzymes of this class. Here, we analyze the structure and phylogenetic distribution of the known exoribonucleases.
Y, Zuo, M P, Deutscher
openaire +4 more sources
A high-throughput fluorescence polarization assay to discover inhibitors of arenavirus and coronavirus exoribonucleases [PDF]
, 2021 Viral exoribonucleases are uncommon in the world of RNA viruses. To date, this activity has been identified only in the Arenaviridae and the Coronaviridae families.
El-Kazzi, Priscila +10 more
core +1 more source
Cap-Independent Circular mRNA Translation Efficiency
Vaccines, 2023 Recently, the mRNA platform has become the method of choice in vaccine development to find new ways to fight infectious diseases. However, this approach has shortcomings, namely that mRNA vaccines require special storage conditions, which makes them less
Andrei A. Deviatkin +9 more
doaj +1 more source
Nature Communications, 2020 Bacterial RNA degradation is typically initiated by endoribonucleases and followed by exoribonucleases. Here the authors report the targetome of endoRNase Y in Streptococcus pyogenes, revealing the interplay between RNase Y and 3′-to-5′ exoribonuclease ...
Laura Broglia +6 more
doaj +1 more source
mBio, 2022 The Bacillus subtilis genome encodes four 3′ exoribonucleases: polynucleotide phosphorylase (PNPase), RNase R, RNase PH, and YhaM. Previous work showed that PNPase, encoded by the pnpA gene, is the major 3′ exonuclease involved in mRNA turnover; in a ...
Shivani Chhabra +4 more
doaj +1 more source