Results 41 to 50 of about 4,940 (209)
Mutational analysis of exoribonuclease I from Saccharomyces cerevisiae [PDF]
Nucleic Acids Research, 1998 Exoribonuclease I from yeast is a 175 kDa protein that is responsible for the majority of cytoplasmic mRNA degradation. Alignment of the Xrn1p sequence with homologs from yeast as well as from higher eukaryotes suggests that the protein is composed of several domains: two acidic N-terminal domains which likely contain the exonuclease, a basic middle ...
A M, Page +4 more
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Bio-Protocol, 2012 Polyadenylation is a post-transcriptional modification of RNA occurring in prokaryotes, eukaryotes and organelles. However, the function and extent of bacterial polyadenylation are in marked contrast to those of eukaryotic poly(A) tails.
Eliane Hajnsdorf
doaj +1 more source
Composition and function of P bodies in Arabidopsis thaliana
Frontiers in Plant Science, 2014 mRNA accumulation is tightly regulated by diverse molecular pathways. The identification and characterization of enzymes and regulatory proteins involved in controlling the fate of mRNA offers the possibility to broaden our understanding of ...
Luis David Maldonado-Bonilla
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Modulating the RNA processing and decay by the exosome: altering Rrp44/Dis3 activity and end-product. [PDF]
PLoS ONE, 2013 In eukaryotes, the exosome plays a central role in RNA maturation, turnover, and quality control. In Saccharomyces cerevisiae, the core exosome is composed of nine catalytically inactive subunits constituting a ring structure and the active nuclease ...
Filipa P Reis +8 more
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BMC Plant Biology, 2023 Background NOL12 5′-3′ exoribonucleases, conserved among eukaryotes, play important roles in pre-rRNA processing, ribosome assembly and export. The most well-described yeast counterpart, Rrp17, is required for maturation of 5.8 and 25S rRNAs, whereas ...
Monika Zakrzewska-Placzek +5 more
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Circular RNA as a Potential Biomarker for Forensic Age Prediction
Frontiers in Genetics, 2022 In forensic science, accurate estimation of the age of a victim or suspect can facilitate the investigators to narrow a search and aid in solving a crime.
Junyan Wang +8 more
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Identification of Genes Potentially Regulated by Human Polynucleotide Phosphorylase (hPNPaseold-35) Using Melanoma as a Model [PDF]
, 2013 Human Polynucleotide Phosphorylase (hPNPaseold-35 or PNPT1) is an evolutionarily conserved 3′→5′ exoribonuclease implicated in the regulation of numerous physiological processes including maintenance of mitochondrial homeostasis, mtRNA import and aging ...
Bacolod, Manny D. +4 more
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Zdorovʹe Rebenka, 2022 This scientific review deals with the mechanisms of action of cytoplasmic microRNAs, namely post-transcriptional silencing: recruitment of the DCP1-DCP2 decapping complex and disruption of the interaction of mRNA with ribosomes.
A.E. Abaturov, V.L. Babуch
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A new yeast poly(A) polymerase complex involved in RNA quality control [PDF]
, 2005 Eukaryotic cells contain several unconventional poly(A) polymerases in addition to the canonical enzymes responsible for the synthesis of poly(A) tails of nuclear messenger RNA precursors.
Štěpánka Vaňáčová +71 more
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Supporting Role for GTPase Rab27a in Hepatitis C Virus RNA Replication through a Novel miR-122-Mediated Effect. [PDF]
PLoS Pathogens, 2015 The small GTPase Rab27a has been shown to control membrane trafficking and microvesicle transport pathways, in particular the secretion of exosomes. In the liver, high expression of Rab27a correlates with the development of hepatocellular carcinoma.
Tzu-Chun Chen +2 more
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