Results 21 to 30 of about 3,495 (190)
iScience, 2021 Summary: Processive exoribonucleases are executors of RNA decay. In humans, their physical but not functional interactions were thoughtfully investigated. Here we have screened cells deficient in DIS3, XRN2, EXOSC10, DIS3L, and DIS3L2 with a custom siRNA
Anna Hojka-Osinska +7 more
doaj +1 more source
Exoribonuclease RNase R protects Antarctic Pseudomonas syringae Lz4W from DNA damage and oxidative stress. [PDF]
Appl Environ Microbiol, 2023 Bacterial exoribonucleases play a crucial role in RNA maturation, degradation, quality control, and turnover. In this study, we have uncovered a previously unknown role of 3-5 exoribonuclease RNase R of Pseudomonas syringae Lz4W in DNA damage and ...
Mittal P +7 more
europepmc +3 more sources
Immunosuppressive arenaviral exoribonuclease
Oncotarget, 2015 Arenaviruses cause up to 500,000 zoonotic infections per year in endemic areas of Africa and South America and can lead to severe and lethal hemorrhagic fever (HF) symptoms [1]. Currently, there is no specific antiviral drug or vaccine available for the treatment of these infections, with the exception of the Candid #1 vaccine that has successfully ...
Bjoern, Meyer, Hinh, Ly
openaire +2 more sources
The roles of the exoribonucleases DIS3L2 and XRN1 in human disease [PDF]
Biochemical Society Transactions, 2016 RNA degradation is a vital post-transcriptional process which ensures that transcripts are maintained at the correct level within the cell. DIS3L2 and XRN1 are conserved exoribonucleases that are critical for the degradation of cytoplasmic RNAs. Although the molecular mechanisms of RNA degradation by DIS3L2 and XRN1 have been well studied, less is ...
Pashler, Amy L +3 more
openaire +2 more sources
Localization of components of the RNA-degrading machine in Bacillus subtilis
Frontiers in Microbiology, 2016 In bacteria, the control of mRNA stability is crucial to allow rapid adaptation to changing conditions. In most bacteria, RNA degradation is catalyzed by the RNA degradosome, a protein complex composed of endo- and exoribonucleases, RNA helicases and ...
Nora Cascante-Estepa +2 more
doaj +1 more source
Depletion of trypanosome CTR9 leads to gene expression defects. [PDF]
PLoS ONE, 2012 The Paf complex of Opisthokonts and plants contains at least five subunits: Paf1, Cdc73, Rtf1, Ctr9, and Leo1. Mutations in, or loss of Paf complex subunits have been shown to cause defects in histone modification, mRNA polyadenylation, and transcription
Benard A Ouna +6 more
doaj +1 more source
mBio, 2021 Regulatory RNAs have emerged as ubiquitous gene regulators in all bacterial species studied to date. The combination of sequence-specific RNA interactions and malleable RNA structure has allowed regulatory RNA to adopt different mechanisms of gene ...
Daniel G. Mediati +2 more
doaj +1 more source
Microorganisms, 2021 Moonlighting proteins are proteins with more than one function. During the past 25 years, they have been found to be rather widespread in bacteria. In Bacillus subtilis, moonlighting has been disclosed to occur via DNA, protein or RNA binding or protein ...
Inam Ul Haq, Sabine Brantl
doaj +1 more source
Purification of eukaryotic exoribonucleases following heterologous expression in bacteria and analysis of their biochemical properties by in vitro enzymatic assays [PDF]
, 2014 Exoribonucleases-among the other RNases-play a crucial role in the regulation of different aspects of RNA metabolism in the eukaryotic cell. To fully understand the exact mechanism of activity exhibited by such enzymes, it is crucial to determine their ...
Krawczyk, Antonina +9 more
core +1 more source
Identification of Ribonuclease Inhibitors for the Control of Pathogenic Bacteria. [PDF]
Int J Mol SciBacteria are known to be constantly adapting to become resistant to antibiotics. Currently, efficient antibacterial compounds are still available; however, it is only a matter of time until these compounds also become inefficient.
Matos RG +4 more
europepmc +3 more sources